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Identification of new high mobility group A1 associated proteins, PROTEOMICS, 2007, 10.1002/pmic.200700148
2 Comments → add new, Giovanna Maria Pierantoni, Francesco Esposito, Stéphane Giraud, Willy Vincent Bienvenut, Jean Jacques Diaz, Alfredo Fusco
High mobility group A (HMGA) proteins (HMGA1a, HMGA1b, HMGA1c and HMGA2) are nonhistone chromosomal proteins that do not have transcriptional activity per se, but they orchestrate the assembly of multiprotein complexes involved in gene transcription, replication and chromatin structure through a complex network of protein–DNA and protein–protein interactions. To better understand their mechanisms of action, we have used a combination of coimmunoprecipitation, 1‐D gel SDS‐PAGE and MS to identify new potential molecular interactors. We have found 11 proteins that associate with HMGA1. These proteins belong to three different classes: mRNA processing proteins, RNA helicases and protein chaperones. Some interactions were confirmed by coimmunoprecipitation and pull‐down experiments in human embryonal kidney 293 cells. These experimental data suggest that HMGA1 proteins can associate with proteins that are strictly involved in chromatin structure and in several important mRNA processing steps, supporting the idea that HMGA1 proteins can also participate in these events.
Unilateral gynecomastia: The assessment of 23 patients, Archives of Clinical and Experimental Surgery (ACES), 2016, 10.5455/aces.20160127010538
1 Comment → add new, Salih Basat, Fatih Ceran, Ilker Uscetin, Ismail Akan, Oguzhan Demirel, Mehmet Bozkurt
Seasonal redistribution of water in the surficial Martian regolith: Results from the Mars Odyssey high-energy neutron detector (HEND), Solar System Research, 2007, 10.1134/s0038094607020013
1 Comment → add new, R. O. Kuzmin, E. V. Zabalueva, I. G. Mitrofanov, M. L. Litvak, A. V. Rodin, W. V. Boynton, R. S. Saunders
The seasonal variation of neutron emissions from Mars in different spectral intervals measured by the HEND neutron detector for the entire Martian year are analyzed. Based on these data, the spatial variations of the neutron emissions from the planet are globally mapped as a function of season, and the dynamics of seasonal variation of neutron fluxes with different energies is analyzed in detail. No differences were found between seasonal regimes of neutron fluxes in different energy ranges in the southern hemisphere of Mars, while the regime of fast neutrons (with higher energies) during the northern winter strongly differs from that during the southern winter. In winter (L s = 270°–330°), the fast neutron fluxes are noticeably reduced in the northern hemisphere (along with the consecutive thickening of the seasonal cap of solid carbon dioxide). This provides evidence of a temporary increase in the water content in the effective layer of neutron generation. According to the obtained estimates, the observed reduction of the flux of fast neutrons in the effective layer corresponds to an increase in the water abundance of up to 5% in the seasonal polar cap (70°–90°N), about 3% at mid-latitudes, and from 1.5 to 2% at low latitudes. The freezing out of atmospheric water at the planetary surface (at middle and high latitudes) and the hydration of salt minerals composing the Martian soil are considered as the main processes responsible for the temporary increase in the water content in the soil and upper layer of the seasonal polar cap. The meridional atmospheric transport of water vapor from the summer southern to the winter northern hemisphere within the Hadley circulation cell is a basic process that delivers water to the subsurface soil layer and ensures the observed scale of the seasonal increase in water abundance. In the summer northern hemisphere, the similar Hadley circulation cell transports mainly dry air masses to the winter southern hemisphere. The point is that the water vapor becomes saturated at lower heights during aphelion, and the bulk of the atmospheric water mass is captured in the near-equatorial cloudy belt and, thus, is only weakly transferred to the southern hemisphere. This phenomenon, known as the Clancy effect, was suggested by Clancy et al. (1996) as a basic mechanism for the explanation of the interhemispheric asymmetry of water storage in permanent polar caps. The asymmetry of seasonal meridional circulation of the Martian atmosphere seems to be another factor determining the asymmetry of the seasonal water redistribution in the “atmosphere-regolith-seasonal polar caps” system, found in the peculiarities of the seasonal regime of the neutron emission of Mars.
MicroRNAs in Brain Metastases: Potential Role as Diagnostics and Therapeutics, International Journal of Molecular Sciences, 2014, 10.3390/ijms150610508
2 Comments → add new, Samer Alsidawi, Ehsan Malek, James Driscoll
Brain metastases remain a daunting adversary that negatively impact patient survival. Metastatic brain tumors affect up to 45% of all cancer patients with systemic cancer and account for ~20% of all cancer-related deaths. A complex network of non-coding RNA molecules, microRNAs (miRNAs), regulate tumor metastasis. The brain micro-environment modulates metastatic tumor growth; however, defining the precise genetic events that promote metastasis in the brain niche represents an important, unresolved problem. Understanding these events will reveal disease-based targets and offer effective strategies to treat brain metastases. Effective therapeutic strategies based upon the biology of brain metastases represent an urgent, unmet need with immediate potential for clinical impact. Studies have demonstrated the ability of miRNAs to distinguish normal from cancerous cells, primary from secondary brain tumors, and correctly categorize metastatic brain tumor tissue of origin based solely on miRNA profiles. Interestingly, manipulation of miRNAs has proven effective in cancer treatment. With the promise of reduced toxicity, increased efficacy and individually directed personalized anti-cancer therapy, using miRNA in the treatment of metastatic brain tumors may prove very useful and improve patient outcome. In this review, we focus on the potential of miRNAs as diagnostic and therapeutic targets for the treatment of metastatic brain lesions.
Proteolysis Inhibitor E-Aminocaproic Acid as Effective Drug for Prevention and Treatment of Influenza, Other Acute Respiratory Viral Infections and their Bacterial Complications, 1st International Electronic Conference on Medicinal Chemistry, 2015, 10.3390/ecmc-1-A050
7 Comments → add new, V. Lozitsky, A. Fedchuk, T. Grydina, L. Shytikova, L. Mudryk, S. Socheslo, M. Lebediuk, O. Voronkov, V. Trykhlib, A. Frolov, V. Zadorozhna, V. Buiko, S. Tkachuk
Using Celebrities in Abnormal Psychology as Teaching Tools to Decrease Stigma and Increase Help Seeking, Teaching of Psychology, 2016, 10.1177/0098628316662765
1 Comment → add new, Anne Ferrari
Research shows that a very small percentage of those who suffer from mental illness seek professional help and fear of stigma is a principal factor why individuals are reluctant to obtain assistance. This study evaluated whether using examples of celebrities’ experiences with mental illness as a form of “contact” with a mentally ill person would reduce public stigma toward mental illness as well as stigma toward obtaining psychological assistance. Data were collected using a pre–post design from 38 (experimental group) and 17 (control group) college undergraduate students enrolled in an abnormal psychology course. Compared to the control group, the use of celebrities as narratives to teach about mental illness resulted in reduced public stigma toward mental illness and reduced stigma toward seeking help.
Enhanced Detection of Human Plasma Proteins on Nanostructured Silver Surfaces, Nanomaterials and Nanotechnology, 2013, 10.5772/56940
1 Comment → add new, Zuzana Orsagova, Andrej Orinak, Renata Orinakova, Lenka Skantarova, Jozef Radonak, Andrej Oriňák Zuzana Orságová Králová
A New Concept in Pumping Unit Technology, SPE Hobbs Petroleum Technology Symposium, 1970, 10.2118/3193-ms
1 Comment → add new, E.W. Metters
The Problematic Forms of Nominalization in English: Gerund, Verbal Noun, and Deverbal Noun, English Linguistics Research, 2014, 10.5430/elr.v4n1p30
1 Comment → add new, Inam Ismael Taher
Deformation of Pure Aluminum Along the Groove Path of ECAP-Conform Process, Advanced Engineering Materials, 2015, 10.1002/adem.201500251
1 Comment → add new, Vahid Ayati, Mohammad Habibi Parsa, Hamed Mirzadeh
Combining of rotary extrusion and equal channel angular pressing (ECAP) leads to the ECAP-Conform process, which is one of the few successful continuous severe plastic deformation processes. Sample before reaching the ECAP die is influenced by three main deformations of rolling, bending, and forging, which can affect the microstructure and mechanical properties of the material. The effects of these steps on the microstructure and properties of AA1100 alloy are studied based on the simulation and experimental investigations. It is found that these steps significantly affect the material and they should be considered for evaluation of properties compared with the conventional ECAP.