Synthesis of new class of ligands derived from isosorbide and their application to asymmetric reduction of aromatic ketones by transfer hydrogenation

Duy HUYNH KHANH; Giang VO-THANH

doi:10.3390/ecsoc-15-00762

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Synthesis of new class of ligands derived from isosorbide and their application to asymmetric reduction of aromatic ketones by transfer hydrogenation

Duy HUYNH KHANH

¹,

Giang VO-THANH

¹ University Paris-Sud

Published: 30 October 2011 by MDPI in The 15th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-15-00762

Abstract: A new class of β-amino alcohol and diamine ligands has been prepared from isosorbide as a chiral renewable source. The efficiency of these ligands has been evaluated for the metal-catalyzed enantioselective reduction of aromatic ketones by transfer hydrogenation, giving excellent conversion and good enantioselectivity.

Keywords: Asymmetric transfer hydrogenation, chiral ligand, isosorbide, aromatic ketones

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