Synthesis of a Serie of 2-Phenylbenzofurans. Structures with Rigid Trans-resveratrol\'s Core and Their Tyrosinase Activity

¹ Dipartimento di Scienze della Vita e dell’Ambiente, Università degli Studi di Cagliari, Macrosezione Biomedica Complesso Universitario di Monserrato, S.S.554, 09042, Monserrato (Cagliari), Italy.
² Dipartimento di Scienze della Vita e dell’Ambiente, Università degli Studi di Cagliari, Macrosezione di Scienze del Farmaco, Via Ospedale 72, 09124 Cagliari, Italy.
³ Departamento de Quımica Organica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Published: 30 October 2012 by MDPI in The 16th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-16-01109

Abstract: Tyrosinases, better termed polyphenoloxidases (EC 1.14.18.1; monophenol, o-diphenol: oxygen oxidoreductase), are copper-containing monooxygenases catalyzing the o-hydroxylation of monophenols to the corresponding catechols (monophenolase activity) and the oxidation of catechols to the corresponding o-quinones (diphenolase activity).

Keywords: tyrosinase, benzofuran, resveratrol

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