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Synthesis and Biological Evaluations of a Series of Novel Azolyl, Azinyl, Pyranyl, Chromonyl and Azepinyl Phosphonates
*
,
Salah A. Abdel-Aziz
,
Somaya M. El-Edfawy
,
El-Hossain A. Mohamed
,
Somaia M. Abdel-Kariem
Published:
31 October 2013
by MDPI
in The 17th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract: A faciles ynthetic methodology of novel azolyl, azinyl and azepinyl phosphonates ascyclic α-aminophosphonates was described. Chromonyl α-aminophosphonates,γ-pyranyl and γ-pyridinyl phosphonates were also prepared. The methodologydepends on reaction of 6-methyl-3-formylchromone, nitrogen and carbon nucleophiles in thepresence of diethyl phosphite in one-pot three component under solvent-freeconditions. The products were evaluated for their antimicrobial activities andantioxidant properties.
Keywords: α-Aminophosphonate, Phosphonate, Chromone, Ring opening and Ring closure, Antimicrobial, Antioxidant
