Welcome from the Chairs

Welcome to The 2nd International Electronic Conference on Synthetic Organic Chemistry

Call for Papers

This will be the 2nd meeting of ECSOC. All accepted presentations will be posted on this website during the conference. Discussions will be possible by using online commenting and reply functions. The Proceedings will be published later online and as a CD-ROM edition. Posters presented may be considered as preliminary communications of new research results or review papers and may be published in another form later in any standard journal. At the authors discretion, contributions will be removed from the web-site after the end of the conference and not included in the online and CD-ROM proceedings editions. Authors are invited to publish their papers subsequently in Molecules.

Sessions

A. General Organic Synthesis
B. Combinatorial Synthesis, Parallel Synthesis and Automation
C. Medicinal and Bioorganic Application of Organic Synthesis
D. Natural Product Isolation and Modification Natural Product Isolation and Modification Natural Product Isolation and Modification
E. Information and Compound Archives Management and Internet Application

Instructions for Authors

Proceedings Paper

Communications for the proceedings issue must have the following organization:

Firstpage:
Title
Full author names
Affiliations and authors' e-mail addresses
Abstract
Keywords

Introduction
Results and Discussion
Experimental Procedure
(Acknowledgements)
References

Communications should be prepared in MS Word. The publication format will be PDF.

Presentation Slides
Authors are encouraged to preare a couple of slides in PowerPoint or similar software, to be displayed online along with the Communication. Slides can be prepared in exactly the same way as for any traditional conference where research results can be presented. Slides should be converted to PDF format before submission.

Submission
Submissions should be done by the authors online by registering with www.sciforum.net, and using the "new submission" function once logged into system.

Copyright
MDPI AG, the publisher of the Sciforum.net platform, is an open access publisher. We believe that authors should retain the copyright to their scholarly works. Hence, by submitting a Communication paper to this conference, you retain the copyright of your paper, but you grant MDPI AG the non-exclusive right to publish this paper online on the Sciforum.net platform. This means you can easily submit your paper to any scientific journal at a later stage and transfer the copyright to its publisher (if required by that publisher).

List of accepted submissions (45)

Id	Title	Authors	Poster PDF
sciforum-000716	Biocatalytic Strategies for the Preparation of Chiral Building Blocks in 100% Chemical and Optical Yield from Racemates U. Felfer , W. Kroutil , U. Strauss , K. Faber Submitted: 31 Oct 1998 Abstract: Show Abstract	U. Felfer , W. Kroutil , U. Strauss , K. Faber	N/A	Show Abstract
Driven by the increased demand for chiral drugs in enantiomerically pure form following the release of new FDA´s marketing guidelines, the search for novel methods for EPC-syntheses is a major topic in contemporary organic synthesis [ 1 ]. In this context, the use of biocatalysts has found widespread application in preparative organic chemistry over the last decade [ 2 ]. From the two principles of biocatalytic reactions where chiral molecules are involved, i.e. (i) desymmetrization of meso- and prochiral compounds [ 3 , 4 ] and (ii) kinetic resolution of racemates [ 5 ], the latter is astonishingly dominant in number of applications (~1:4) [ 6 ], which is probably due to the fact that meso- and prochiral substrates are less easily synthesized than racemates. Despite its widespread application, kinetic resolution is impeded by several inherent disadvantages for practical applications, in particular on an industrial scale. After all, it should be kept in mind that an ideal resolution process should provide a single enantiomeric product in 100 % yield. The most obvious drawbacks are as follows: (i) The theoretical yield of each enantiomer can never exceed a limit of 50 %, (ii) separation of the formed product from the remaining substrate may be laborious, in particular for those cases, where simple extraction or distillation fails and chromatographic methods are required [ 7 ]. (iii) In the majority of processes, only one stereoisomer is desired and there is little or no use for the other. In some rare cases, the unwanted isomer may be used through a separate pathway in an enantio-convergent fashion, but this requires additional labour and a highly flexible synthetic strategy [ 8 ]. (iv) For kinetic reasons, the optical purity of substrate and/or product is depleted at the point, where separation of product and substrate is most desirable from a preparative standpoint - i.e. 50 % conversion
sciforum-000717	Recent Developments in the Area of Asymmetric Transfer Hydrogenation. Martin Wills , Matthew Palmer , Athene Smith , Jennifer Kenny Submitted: 31 Oct 1998 Abstract: Show Abstract	Martin Wills , Matthew Palmer , Athene Smith , Jennifer Kenny	N/A	Show Abstract
The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of a-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom.
sciforum-000718	Thermal Cyclization of 2-Hydrazonoacyl-3-oxo-heterocycles to Pyrazolo[4,3-c]fused Heterocycles Wolfgang Stadlbaur , Gerhard Hojas , Werner Fiala Submitted: 31 Oct 1998 Abstract: Show Abstract	Wolfgang Stadlbaur , Gerhard Hojas , Werner Fiala	N/A	Show Abstract
1-Aryl-pyrazolo[4,3-c]quinolin-3-ones 1 reveal interesting structures because of their potential biological activity [1]. A binding study on bovine brain membranes has shown that 1-aryl- pyrazolo[4,3-c]quinolin-3-ones 1 bearing different substituents at position 4 possess activity in displacing specific [3H]flunitrazepam from its receptor site [2]. In this paper we present new strategies for the synthesis of 1-aryl- or 2-arylamino-pyrazolo[4,3-c]fused heterocycles such as 1-aryl-pyrazolo[4,3-c]fused quinolines and coumarins having hydrogen-, methyl- or aryl-substituents at position 3. The cyclization conditions were studied by differential scanning calorimetry (DSC).
sciforum-000720	Reactivity of styrene derivatives: Nucleophilic addition versus 1,2-wittig rearrangement Julio Seijas , M. Vàsquez-Tato , Luis Barreiro-Castro Submitted: 31 Oct 1998 Abstract: Show Abstract	Julio Seijas , M. Vàsquez-Tato , Luis Barreiro-Castro	N/A	Show Abstract
Wittig rearrangements have been studied for a long time, the [2,3]-rearrangement being the most widely studied, and there are many reports on its mechanistic and synthetic applications {1}. The corresponding [1,2]-rearrangement has been studied too, but has not been so widely used as a synthetic tool, remaining mainly as a competitive reaction that interferes with the other possible rearrangements.
sciforum-000721	Synthesis of 2-Alkylbenzoic Acids: Alkyllithium Additions to 2-Vinylbenzoic Acid Julio Seijas , M. Vàsquez-Tato , M. Martinez Submitted: 31 Oct 1998 Abstract: Show Abstract	Julio Seijas , M. Vàsquez-Tato , M. Martinez	N/A	Show Abstract
Recently there has been an increasing interest in the chemistry of nucleophilic additions to styrene and its derivatives {1-6}. Although there were some early reports on the addition of nucleophiles to styrene without leading to polymerization, the synthetic application of this reaction was not exploited until our group started new studies on its chemistry{1}. Now that the synthetic viability of these additions has been established, it is of great interest to study the scope of the reaction. Here we present our studies on the addition of alkyllithiums to 2-vinylbenzoic acid (1). In an earlier report {4} of the reaction of 1 with BuLi, the expected product was obtained only in a 19% yield. As the authors did not mention any reason for the low yield we decided to study this addition to see if there was any incompatibility between the carboxylic acid group and the alkyllithium. There could be a competition between the reaction of addition to carboxylate to give a ketone and the addition to the exocyclic double bond.