Addition of Thiocyanic Acid to Chalcones: Practical Synthesis of 1,3-Diaryl-3-isothiocyanatopropan-1-ones

Anastasia Fesenko; Pavel Solovyev; Anatoly Shutalev

doi:10.3390/ecsoc-20-a017

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A Novel Ring Expansion of Pyrimidines to 1,2,4-Triazepines

Addition of Thiocyanic Acid to Chalcones: Practical Synthesis of 1,3-Diaryl-3-isothiocyanatopropan-1-ones

Anastasia Fesenko

¹,

Pavel Solovyev

²,

Anatoly Shutalev

^{*

1}

¹ N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., 119991 Moscow, Russian Federation
² Department of Organic Chemistry, Moscow Technological University, 86 Vernadsky Avenue, 119571 Moscow, Russian Federation

Published: 01 November 2016 by MDPI in The 20th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-20-a017

Abstract:

Practical synthesis of 1,3-diaryl-substituted 3-isothiocyanatopropan-1-ones based on the reaction of chalcones with thiocyanic acid generated in situ by treatment of thiocyanate ammonium with dilute sulfuric acid has been developed.

Keywords: Chalcones; Isothiocyanates; Ketones; Thiocyanic acid; Addition

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Anastasia Fesenko

Pavel Solovyev

Anatoly Shutalev