In the present study, a melamine-modified hydrogel was synthesized for use as Doxorubicin delivery carrier. In the first step, poly(acrylic acid-co-maleic anhydride) was synthesized via free radical polymerization. Then the prepared copolymer was crosslinked by melamine to obtain the final carrier. The swelling behavior of the carrier was carried out afterwards. Moreover, different analyses such as FT-IR, TGA and SEM techniques were used to characterize the final polymer. In the final step, the Doxorubicin drug was loaded on the polymer and the slow-release study of the drug was investigated.