Synthesis of novel complex conjugated imines containing a fragment of the anticancer drug imatinib

¹ laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Ciudad Universitaria, C.P. 58033, Morelia, Michoacán, México
² Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Ciudad Universitaria, C.P. 58033, Morelia, Michoacán, México
³ Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato, C.P. 36050, Guanajuato, Gto., México

Published: 03 November 2017 by MDPI in The 21st International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-21-04735

Abstract:

A series of imine analogs of anticancer drug imatinib were synthesized in moderate to good yields, under ecofriendly conditions. Some compounds containing fluorine atoms and important medicinal chemistry scaffolds such as chromone, pyridine and pyrrole. These compounds could have potential applications in medicinal chemistry as antifungal, antibacterials and mainly Abl tyrosine kinase inhibitors.

Keywords: conjugated Imines, ecofriendly, Imatinib, Phenylaminopyrimide (PAP)

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