Synthesis of new functionalized thieno[2,3-b]pyridines

Darya Lukina; Angela Stolyarova; Victor Dotsenko

doi:10.3390/ecsoc-21-04853

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Synthesis of new functionalized thieno[2,3-b]pyridines

Darya Yu Lukina

Angela N. Stolyarova

Victor V. Dotsenko

¹ Kuban State University, 149 Stavropolskaya Str., Krasnodar 350040, Russian Federation
² ChemEx Lab, Vladimir Dal’ Lugansk National University, Lugansk, 91034 Russia.
³ North-Caucasus Federal University, 1 Pushkina St., 355009 Stavropol, Russian Federation

Published: 07 November 2017 by MDPI in The 21st International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-21-04853

Abstract:

3-Aminothieno[2,3-b]pyridine-2-carboxamides react with chloroacetyl chloride to afford 3-(chloroacetylamino)thieno[2,3-b]pyridine-2-carboxamides. The latter upon treatment with sodium azide gave 3-(azidoacetylamino)thieno[2,3-b]pyridine-2-carboxamides. The reaction of 3-(chloroacetylamino)thieno[2,3-b]pyridine-2-carboxamides with sulfur and amines afforded new monothiooxamides.

Keywords: thieno[2,3-b]pyridines, acylation, azides, monothiooxamides

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Darya Lukina

Angela Stolyarova

Victor Dotsenko