Poly(ethylene glycol) Supported Synthesis of Aminoacid Derivatives via Ring Closing Metathesis or Microwave-assisted Alkylation

Stéphane Varray; Bérengère Sauvagnat; Christine Gauzy; Frédéric Lamaty; René Lazaro; Jean Martinez

doi:10.3390/ecsoc-4-01890

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Dendrimers as Scavengers for Rapid Purification in Solution-Phase Parallel Synthesis

Poly(ethylene glycol) Supported Synthesis of Aminoacid Derivatives via Ring Closing Metathesis or Microwave-assisted Alkylation

Stéphane Varray

Bérengère Sauvagnat

Christine Gauzy

Frédéric Lamaty

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René Lazaro

Jean Martinez

¹ Laboratoire des Aminoacides, Peptides et Protéines (LAPP), CNRS-Universités Montpellier 1 et 2, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France

Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session Solid Phase Chemistry and Combinatorial Synthesis

https://doi.org/10.3390/ecsoc-4-01890

Abstract: Ring closing metathesis has been performed for the first time on a soluble poly(ethylene glycol) supported substrate in the presence of Grubbs' catalyst and provided in good yields 6-, 7- and 8-membered ring aminoacid derivatives. The presence of the polymer required the use of a higher amount of ruthenium complex but the addition of a cofactor such as 1-octene improved the turnover of the catalyst. On the other hand, a Schiff base protected glycine supported on a poly(ethylene glycol) reacted readily with various electrophiles in the presence of an inorganic base under microwave activation.

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