Development of Multi-Gram Scale Microwave Assisted Organic Synthesis (MAOS): Suzuki Coupling towards 2,4-Dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one (Tasosartan)

Klaus Gerdes; Ulrich Jordis; C. Kappe; Jennifer Kremsner

doi:10.3390/ecsoc-9-01637

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Development of Multi-Gram Scale Microwave Assisted Organic Synthesis (MAOS): Suzuki Coupling towards 2,4-Dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one (Tasosartan)

Klaus Gerdes

¹,

Ulrich Jordis

^{*

1},

C. Oliver Kappe

²,

Jennifer M. Kremsner

¹ Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austria
² Institute of Chemistry, Karl Franzens Universität Graz, Heinrichstrasse 28, 8010 Graz, Austria

Published: 01 November 2005 by MDPI in The 9th International Electronic Conference on Synthetic Organic Chemistry session Symposium on Microwave Assisted Synthesis

https://doi.org/10.3390/ecsoc-9-01637

Abstract: The improved synthesis of 2,4-dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d] pyrimidin-7-one (tasosartan-1, click for 3D-structure) on multigramscale is described. The synthesis was developed in context of the DrugMatrix-genomics project.

Keywords: angiotensine II antagonist; Suzuki-coupling; microwave

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Klaus Gerdes

Ulrich Jordis

C. Kappe

Jennifer Kremsner