Please login first
Structure – Activity Relationships (SARs) of Antioxidant Molecule
* , , ,
1  School of Science, Technology and Engineering Management, St. Thomas University, Miami Gardens, FL 33054, USA

Abstract:

Structure – Activity Relationships (SARs) of Antioxidant Molecules

Luis E. Castellar, Langeda Bontemps, Leslie Robinson, and Luis C. Fernandez-Torres

School of Science, Technology, and Engineering Management, St. Thomas University, Miami Gardens, FL 33054

The public’s demand for antioxidant supplements has increased recently. As more of these supplements hit the market, an understanding of what makes a molecule a good antioxidant is paramount. The aim of this research project is to evaluate the antioxidant capacity of several phenols and related derivatives using the Briggs-Rauscher (BR) oscillatory reaction. The antioxidant species scavenge free radicals formed in the BR reaction, lengthening the time intervals of the reaction’s oscillations; the higher the antioxidant capacity, the longer the oscillation delays. In phenol structures, the amount of hydroxyl (OH) withdrawing groups affects the antioxidant capacity. By adding a hydroxyl group in a specific ring position, such as ortho or para, an increase of antioxidant capacity was observed. Previous research supports that ortho substitution of an electron donor increases the stability of the phenol radicals. Our results showed that meta substituted phenols were the most active antioxidants. We rationalize this observation by considering the low pH (~2) of the Briggs-Rauscher reaction. It was also noticed that a monophenol showed less antioxidant capacity than a polyphenol structure. Finally, we observed that the number of OH substituent does affect the antioxidant capacity.

Top