Microfluidics is a multidisciplinary technology which enables the face-lift crossing a wide range of applications such as life science research, point-of-care diagnostics and personal medicine. Polymer materials, especially thermoplastics, are dominating this emerging market due to the low material cost and the ease of mass production. This talk reports the new development of major fabrication technologies for making polymer, especially thermoplastic microfluidic chips, including micro tooling, injection molding, bonding and surface treatment. The talk also discusses about the key challenges in fulfilling the needs of next generation microfluidic products.