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Recent CMV Research

In developed countries, human cytomegalovirus (CMV) is the major infectious cause of congenital birth defects including microcephaly, mental retardation, sensorineural hearing loss, and intrauterine growth restriction. Nonetheless, because of the potential for teratogenicity and toxic effects, no prenatal therapeutic treatment is currently approved by the Food and Drug Administration for congenital CMV infection. Therefore there is great interest in understanding CMV growth and blocking or altogether preventing CMV infection.

In the “Recent CMV Research” special issue in Viruses, of particular interest to families and caregivers affected by CMV diseases are several papers: addressing prevention of CMV infection of trophoblast cells (Zydek et al., 2014), CMV latency (Sinclair and Reeves, 2013), as well as of CMV lung infections in non-HIV infected children (Restrepo-Gualteros et al., 2014). Our ability to enhance immune responses for controlling CMV infection (Hanley and Bollard, 2014) and new strategies for CMV vaccine development guided by non-human primate studies (Deere and Barry, 2014) are discussed in two excellent reviews. Several articles address the CMV manipulation of the immune system, both innate and adaptive immune responses (Stevenson et al., 2014, Fink et al, 2013, 2014, Raghavan et al., 2014) and of DNA damage responses (E and Kowalik, 2014; Kulkarni and Fortunato, 2014). Please find all the papers in this special issue in the ‘Bibliography’ section.

It is my hope that this special issue provides a valuable resource for the families and investigators in the CMV field. I would like to thank all the colleagues who contributed papers to this Special Issue and invite discussions on these papers. In fact the publisher selected two of the papers from this special issue (Zydek et al., 2014; Deere and Barry, 2014) to highlight in the MDPI Magazine.

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Citations

1. Sinclair, J.; Reeves, M. Human Cytomegalovirus Manipulation of Latently Infected Cells. Viruses 2013, 5, 2803-2824; doi:10.3390/v5112803
2. Fink, A.; Renzaho, A.; Reddehase, M.; Lemmermann, N. The p36 Isoform of Murine Cytomegalovirus m152 Protein Suffices for Mediating Innate and Adaptive Immune Evasion. Viruses 2013, 5, 3171-3191; doi:10.3390/v5123171
3. Graf, L.; Webel, R.; Wagner, S.; Hamilton, S.; Rawlinson, W.; Sticht, H.; Marschall, M. The Cyclin-Dependent Kinase Ortholog pUL97 of Human Cytomegalovirus Interacts with Cyclins. Viruses 2013, 5, 3213-3230; doi:10.3390/v5123213
4. Martínez, F.; Tang, Q. Identification of Cellular Proteins that Interact with Human Cytomegalovirus Immediate-Early Protein 1 by Protein Array Assay. Viruses 2013, 6, 89-105; doi:10.3390/v6010089
5. Reyda, S.; Büscher, N.; Tenzer, S.; Plachter, B. Proteomic Analyses of Human Cytomegalovirus Strain AD169 Derivatives Reveal Highly Conserved Patterns of Viral and Cellular Proteins in Infected Fibroblasts. Viruses 2014, 6, 172-188; doi:10.3390/v6010172
6. Dufrene, K.; DeBiasi, R.; Colberg-Poley, A. Preface of the Special Issue: “Recent CMV Research”. Viruses 2014, 6, 336-339; doi:10.3390/v6010336
7. Elbasani, E.; Gabaev, I.; Steinbrück, L.; Messerle, M.; Borst, E. Analysis of Essential Viral Gene Functions after Highly Efficient Adenofection of Cells with Cloned Human Cytomegalovirus Genomes. Viruses 2014, 6, 354-370; doi:10.3390/v6010354
8. Schleiss, M.; McAllister, S.; Armién, A.; Hernandez-Alvarado, N.; Fernández-Alarcón, C.; Zabeli, J.; Ramaraj, T.; Crow, J.; McVoy, M. Molecular and Biological Characterization of a New Isolate of Guinea Pig Cytomegalovirus. Viruses 2014, 6, 448-475; doi:10.3390/v6020448
9. Rana, R.; Biegalke, B. Human Cytomegalovirus UL34 Early and late Proteins Are Essential for Viral Replication. Viruses 2014, 6, 476-488; doi:10.3390/v6020476
10. Smith, R.; Kosuri, S.; Kerry, J. Role of Human Cytomegalovirus Tegument Proteins in Virion Assembly. Viruses 2014, 6, 582-605; doi:10.3390/v6020582
11. Niemann, I.; Reichel, A.; Stamminger, T. Intracellular Trafficking of the Human Cytomegalovirus-Encoded 7-trans-Membrane Protein Homologs pUS27 and pUL78 during Viral Infection: A Comparative Analysis. Viruses 2014, 6, 661-682; doi:10.3390/v6020661
12. Stevenson, E.; Collins-McMillen, D.; Kim, J.; Cieply, S.; Bentz, G.; Yurochko, A. HCMV Reprogramming of Infected Monocyte Survival and Differentiation: A Goldilocks Phenomenon. Viruses 2014, 6, 782-807; doi:10.3390/v6020782
13. Gnanandarajah, J.; Gillis, P.; Hernandez-Alvarado, N.; Higgins, L.; Markowski, T.; Sung, H.; Lumley, S.; Schleiss, M. Identification by Mass Spectrometry and Immune Response Analysis of Guinea Pig Cytomegalovirus (GPCMV) Pentameric Complex Proteins GP129, 131 and 133. Viruses 2014, 6, 727-751; doi:10.3390/v6020727
14. Fink, A.; Büttner, J.; Thomas, D.; Holtappels, R.; Reddehase, M.; Lemmermann, N. Noncanonical Expression of a Murine Cytomegalovirus Early Protein CD8 T-Cell Epitope as an Immediate Early Epitope Based on Transcription from an Upstream Gene. Viruses 2014, 6, 808-831; doi:10.3390/v6020808
15. Kulkarni, A.; Fortunato, E. Modulation of Homology-Directed Repair in T98G Glioblastoma Cells Due to Interactions between Wildtype p53, Rad51 and HCMV IE1-72. Viruses 2014, 6, 968-985; doi:10.3390/v6030968
16. Sijmons, S.; Ranst, M. V.; Maes, P. Genomic and Functional Characteristics of Human Cytomegalovirus Revealed by Next-Generation Sequencing. Viruses 2014, 6, 1049-1072; doi:10.3390/v6031049
17. Noriega, V.; Gardner, T.; Redmann, V.; Bongers, G.; Lira, S.; Tortorella, D. Human Cytomegalovirus US28 Facilitates Cell-to-Cell Viral Dissemination. Viruses 2014, 6, 1202-1218; doi:10.3390/v6031202
18. Raghavan, B.; Cook, C.; Trgovcich, J. The Carboxy Terminal Region of the Human Cytomegalovirus Immediate Early 1 (IE1) Protein Disrupts Type II Inteferon Signaling. Viruses 2014, 6, 1502-1524; doi:10.3390/v6041502
19. Bhuvanendran, S.; Salka, K.; Rainey, K.; Sreetama, S.; Williams, E.; Leeker, M.; Prasad, V.; Boyd, J.; Patterson, G.; Jaiswal, J.; Colberg-Poley, A. Superresolution Imaging of Human Cytomegalovirus vMIA Localization in Sub-Mitochondrial Compartments. Viruses 2014, 6, 1612-1636; doi:10.3390/v6041612
20. Restrepo-Gualteros, S.; Jaramillo-Barberi, L.; Gonzalez-Santos, M.; Rodriguez-Martinez, C.; Perez, G.; Gutierrez, M.; Nino, G. Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children. Viruses 2014, 6, 2038-2051; doi:10.3390/v6052038
21. E, X.; Kowalik, T. The DNA Damage Response Induced by Infection with Human Cytomegalovirus and Other Viruses. Viruses 2014, 6, 2155-2185; doi:10.3390/v6052155
22. Hanley, P.; Bollard, C. Controlling Cytomegalovirus: Helping the Immune System Take the Lead. Viruses 2014, 6, 2242-2258; doi:10.3390/v6062242
23. Yang, Z.; Vu, G.; Qian, H.; Chen, Y.; Wang, Y.; Reeves, M.; Zen, K.; Liu, F. Engineered RNase P Ribozymes Effectively Inhibit Human Cytomegalovirus Gene Expression and Replication. Viruses 2014, 6, 2376-2391; doi:10.3390/v6062376
24. Zydek, M.; Petitt, M.; Fang-Hoover, J.; Adler, B.; Kauvar, L.; Pereira, L.; Tabata, T. HCMV Infection of Human Trophoblast Progenitor Cells of the Placenta Is Neutralized by a Human Monoclonal Antibody to Glycoprotein B and Not by Antibodies to the Pentamer Complex. Viruses 2014, 6, 1346-1364; doi:10.3390/v6031346
25. Deere, J.; Barry, P. Using the Nonhuman Primate Model of HCMV to Guide Vaccine Development. Viruses 2014, 6, 1483-1501; doi:10.3390/v6041483

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Created by: Samanta La Russa
Created on: 17 November 2014

Full group description

In developed countries, human cytomegalovirus (CMV) is the major infectious cause of congenital birth defects including microcephaly, mental retardation, sensorineural hearing loss, and intrauterine growth restriction. Nonetheless, because of the potential for teratogenicity and toxic effects, no prenatal therapeutic treatment is currently approved by the Food and Drug Administration for congenital CMV infection. Therefore there is great interest in understanding CMV growth and blocking or altogether preventing CMV infection.

In the “Recent CMV Research” special issue in Viruses, of particular interest to families and caregivers affected by CMV diseases are several papers: addressing prevention of CMV infection of trophoblast cells (Zydek et al., 2014), CMV latency (Sinclair and Reeves, 2013), as well as of CMV lung infections in non-HIV infected children (Restrepo-Gualteros et al., 2014). Our ability to enhance immune responses for controlling CMV infection (Hanley and Bollard, 2014) and new strategies for CMV vaccine development guided by non-human primate studies (Deere and Barry, 2014) are discussed in two excellent reviews. Several articles address the CMV manipulation of the immune system, both innate and adaptive immune responses (Stevenson et al., 2014, Fink et al, 2013, 2014, Raghavan et al., 2014) and of DNA damage responses (E and Kowalik, 2014; Kulkarni and Fortunato, 2014). Please find all the papers in this special issue in the ‘Bibliography’ section.

It is my hope that this special issue provides a valuable resource for the families and investigators in the CMV field. I would like to thank all the colleagues who contributed papers to this Special Issue and invite discussions on these papers. In fact the publisher selected two of the papers from this special issue (Zydek et al., 2014; Deere and Barry, 2014) to highlight in the MDPI Magazine.

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