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Karina Spunde got degree of Doctor of biology in 2005 with thesis “Antisense and Virus Trans-activator Decoy Approaches of Inhibiting Replication of Human T-cell Lymphotropic Virus Type 1 (HTLV-1)”. The study was conducted in August Kirchenstein Institute of Microbiology and Virology, where she was employed since 1994. The research was devoted to gene therapy of viral infections, particularly specific inhibition of HTLV-BLV group retroviruses replication by antisense RNA. Since 2008 she is a researcher in department of Protein Engineering of Latvian Biomedical Research and Study Centre Hepatitis B (HBV) and hepatitis C (HCV) viruses are the main subjects of the studies in the department. The application of the alphavirus based expression system allows for efficient production of HBV proteins in mammalian cells. One of the research directions is study of HBV particles morphogenesis in mammalian cells, where formation, stability, and release of viral and subviral particles are investigated. Another direction, is generation of an authentic HBV in vitro replication model, appropriate for evaluation of anti-HBV drugs, where we propose to initiate HBV replication by recombinant alphaviral replicons. Presently she is working on application of alphavirus based vectors for cancer gene therapy.
Karina Spunde got degree of Doctor of biology in 2005 with thesis “Antisense and Virus Trans-activator Decoy Approaches of Inhibiting Replication of Human T-cell Lymphotropic Virus Type 1 (HTLV-1)”. The study was conducted in August Kirchenstein Institute of Microbiology and Virology, where she was employed since 1994. The research was devoted to gene therapy of viral infections, particularly specific inhibition of HTLV-BLV group retroviruses replication by antisense RNA. Since 2008 she is a researcher in department of Protein Engineering of Latvian Biomedical Research and Study Centre Hepatitis B (HBV) and hepatitis C (HCV) viruses are the main subjects of the studies in the department. The application of the alphavirus based expression system allows for efficient production of HBV proteins in mammalian cells. One of the research directions is study of HBV particles morphogenesis in mammalian cells, where formation, stability, and release of viral and subviral particles are investigated. Another direction, is generation of an authentic HBV in vitro replication model, appropriate for evaluation of anti-HBV drugs, where we propose to initiate HBV replication by recombinant alphaviral replicons. Presently she is working on application of alphavirus based vectors for cancer gene therapy.
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