This group is a journal club to start a series of scientific seminars that focus on biofilm formation, the role of biofilm formation control and food safety, Biofilm, and chronic veterinary diseases. We invite all researchers to attend and share their knowledge
t Often promissing active molecules are abbandoned as they can not fulfilled their therapeutic objetives due to unappropriate formulations. The scope of this group is to find the best formulation to deliver active molecules to the intented targets. To achieve that it is intended to compare conventional formulations with nanoformulations, made from lipic and polymeric raw materials. A platform of nanotecnologies as toolls to fromulate any kind of molecules of the Action will be created.
The protection of healthcare workers is one of the priority in the response against Covid-19.
More generally, ensuring health and safety at workplace for all workers could play an important role for limiting the spread of the SARS-CoV-2 and to curb the increasing levels of the Covid-19 infections across the countries.
That is, ensuring high levels of occupational health could have a subsequent positive impact on public health as well.
Occupational environment could be the ideal setting to do prevention against a big deal like the high rates of Covid-19 transmissibility, through information and training of workers and employers, as well as contact tracing activities and other monitoring strategies.
Sharing data and experiences among occupational physicians could also be a useful mean of reaching higher levels of knowledge and improving occupational phsycisians' attitude and risk perception to take the necessary actions to address this hot issue.
I as Theoretician for the 5th Wave/Tomorrow Age Theory, believe tomorrow shock, we have three factors: knowledge, tecgnology and business (KTB) and based on the 5th wave/tomorrow age theory since 100 years ago the business and economic revolution is happened and developed but we are not prepared for tomorrow!
we have to prepare ourselves to forecast, prevention and get readiness for facing tomorrow shock, we are passing today and entring to the edge of tomorrow! that means we need infrastructure and structured comprehensive sustainable innovative strategic plan.
The ERK signaling pathway plays a central role in the control of various cellular processes such as proliferation, survival, differentiation and development, but apoptosis and stress response as well. Compartmentalization and dynamic localization of ERK signaling is an important regulatory mechanism of specific biological processes. Consistent with its critical role in key cellular functions, deviation in the normal activities of this pathway has been implicated in the development of many human diseases involving different organs. In particular, mutations hitting the ERK signaling are involved in autosomal-dominant syndromes known as RASopathies. The major complications of these disorders are congenital cardiac defects and development of hypertrophic cardiomyopathy. Furthermore, in the neuronal system ERK has been correlated to different pathological contexts, including stroke, autism and neurodegenerative diseases such as Multiple Sclerosis, Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis. In the nervous system ERK pathway regulates various cellular activities including neuron apoptosis through induction of excitotoxicity, neuroinflammation and innate immunity. In addition, ERK has been deeply investigated as anti-cancer target molecule for its important role in tumorigenesis in particular in cancer cell proliferation, migration and invasion. Finally, ERK has been also associated to the development of side effects derived from anti-cancer therapies, such as cardiotoxicity due to chemotherapeutic treatments. Overall, these data suggest that a major comprehension of the pathological mechanisms regulated by the ERK pathway will allow the development of new functional therapies for a great range of diseases with a strong impact on public health.
In this Special Issue of the International Journal of Molecular Sciences the focus will be on the role of the ERK signaling pathway in various pathologies, such as cancer, developmental disorders and diseases affecting the cardiovascular and nervous system.
Professor Tiziana Crepaldi
Special Issue Submission Deadline: Early 2019.
IJMS (International Journal of Molecular Sciences)Impact Factor 3.226 (2016 Journal Citation Reports®)Homepage: http://www.mdpi.com/journal/ijmsLindedIn: http://www.linkedin.com/in/ijmsjournalIJMS channel on Twitter (@IJMS_MDPI)
Essential Oils: From Phytochemistry to Ecophysiological Significances and Their Applications
In modern sustainable industries, “green products”, based on natural compounds, are of the highest importance. From this standpoint, essential oils are considered the most widely used natural products in many areas. Most of them have been used as fragrances, flavoring agents or as medicines since ancient times. At present, a renaissance of the research on essential oils in the traditional but also new industries is observed. Essential oils are extensively studied to treat various human ailments, for their potential cosmetic applications, but also for crop protection, as so-called botanical pesticides. This Special Issue is in connection with the Biological Activities of Essential Oils International Conference by Le Studium with the aim to give an overview of the modern biological applications and activities of essential oils. In addition, their phytochemistry and ecophysiological significances are also considered. For that purpose, original research articles, reviews, industrial cases, and short communications are also welcomed and encouraged.
Special Issue from Plants (MDPI):
Deadline for manuscript submissions: 30 November 2019
International Conference from Le Studium Loire Valley Institute for Advanced Studies
Please find additional information on this Conference at: http://www.lestudium-ias.com/event/biological-activities-essential-oils
The use of plant in vitro (bio)technologies offers an attractive alternative for the production of plant-based active ingredients. Plant cells are small factories able to synthesize an exceptional variety of commercially important phytochemicals used as flavors, dyes, pharmaceuticals, nutraceuticals, cosmeceuticals, etc. Conventional plant propagation techniques are subjected to variety of pests, environmental challenges and poor management practices that adversely affect the quality and yield of these valuable phytochemicals. Plant in vitro culture platform offers considerable advantages and advancements over conventional phytochemical production techniques. However, during culture development, the yield of metabolites is generally low due to poor understanding of various factors that affect the biosynthetic pathway. Therefore, various strategies have been developed and reported to enhance biosynthesis of these phytochemicals in plant cell cultures. The recent emergence of omics technologies, molecular biology, metabolic engineering and synthetic biology has revolutionized diverse fields in life sciences. These modern aspects of life sciences have considerably influencing plant in vitro technology and phytochemical production. An application of these technologies is expanding horizons for an understanding of metabolic pathways involved in the biosynthesis of valuable biologically active ingredients and their cost-efficient production.