Transfer Of Protons Into A New Organic Compound Based On

: Hydrogen bonds are of paramount importance for biological processes, they are energet-12


Introduction
Creatinine (2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one) is an organic biomolecule used in the synthesis of some charge transfer organic compounds [1], these organic compounds have also a predominant role in a wide range of chemical and biochemical processes such as solvation, catalytic, enzymatic reactions [2,3], and acid-base neutralization [4].Although the development of creatininium salts continues to grow and a considerable number of research groups have gained great interest,a search in the Cambridge Structural Database CSD (ConQuest Version 2021.2) [5] for crustal structures containing creatininium molecules results in 26hits, 24 of them crystallize in a centro symmetric space group.

Synthesis of Bis creatininium fumarate fumaric acid(BCFF)
The single crystals of (BCFF) were obtained by slow evaporation of a mixture of two aqueous solutions, Creatinine and fumaric acid, according to the following reaction: Single crystals were obtained after a few weeks, by slow evaporation at room temperature.

Resolution Structural and Refinement Of the tructure
The refinement of the lattice parameters and the data collection of a transparent prismatic crystal, of dimension (0.75 x 0.51 x 0.27 mm), was carried out on a Gemini Oxford diffractometer equipped with an associated CCD detector [6], with Kα radiation of molybdenum (λ = 0.71073 Å).
The crystallographic data and the recording conditions are given in the following table.
Table 1.Main crystallographic data and structure refinement for compound (BCFF).
X-ray diffraction and resolution with adequate software shows that the compound crystallizes in a monoclinic crystal systems with a centro-symmetric space group (P21 / c).
The reliability factors R and WR reveal the good quality of the refinement.
The large number of reflections and the quality of the data allo wed us to make a good structural resolution [7].

Discussion of Structure
The asymmetric unit of (BCFF) consists of a creatinium cation (A), half of a fumarate anion (B) and half of a neutral molecule of fumaric acid (C). the creatinium cation is monoprotonated at the level of the imino group N1.The characteristic hydrogen bonds of this compound are reported in the following Table : Table 2. Hydrogen bond lengths (Å) and angles (º).(BCFF).

Conclusion
The crystal structure of the compound Bis Creatininum fumarate fumaric acid crystallizes in the P21 / C space group of the monoclinic system, is built on the basis of an asymmetric unit consisting of two Creatininium cations 2 (C4H8N3O) + the fumarate ion (C4H2O4) -2 and a fumaric acid molecule C4H4O4.
Intermolecular cohesion is ensured by a network of hydrogen bonds of the (O-H… O), (N-H… O) type between the organic cation creatinium, the fumarate anion and fumaric acid.
The crystalline edifice, allowed us to determine their binary graphs, formed mainly by finite and infinite cycles and chains, as well as the higher order graphs between several types of bonds.

Figure 3 .
Figure 3.View of the ionic structure of (BCFF), showing the immediate hydrogen-bonded between creatininium, fumarate and fumaric acid.