Kigelia africana is used in traditional medicine and toxicological effects of the different extracts of the fruit, bark of the stem and leaf but not of its flowers have been reported, so the present investigation aims to determine the toxic potential of the aqueous extract obtained from the flowers of Kigelia africana by the acute toxic class method in Balb/c mice. An aqueous extract of the flowers was obtained, which was administered orally at a single dose of 50, 500 and 2000 mg/Kg and three Balb/c mice of different sexes were used in each level. With the administration of 50 and 500 mg/Kg doses, 100% survival was obtained, the daily systematic observations, the macroscopic analysis of the organs and their body weight showed no evidence of any sign of toxicity unlike the doses of 2000 mg/Kg where the deaths were observed in 48 hours being the main clinical symptoms depression of the central nervous system and polyuria marked with signs and symptoms of dehydration. The product can be classified in category 4.