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New clinical application of three-dimensional-printed polycaprolactone/β-tricalcium phosphate scaffold as an alternative to allograft bone for limb-sparing surgery in a dog with distal radial osteosarcoma
Seongjae Choi, 1 Ye-In Oh, 2 Keun-Ho Park, 3 Jeong-Seok Lee, 3 Jin-Hyung Shim, 3 Byung-Jae Kang 1
1  Department of Veterinary Surgery, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Republic of Korea
2  Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea
3  Department of Mechanical Engineering, Korea Polytechnic University, Siheung 15073, Republic of Korea

Published: 18 January 2019 by Japanese Society of Veterinary Science in Journal of Veterinary Medical Science
Japanese Society of Veterinary Science, Volume 81; 10.1292/jvms.18-0158
Abstract: Limb-sparing surgery is one of the surgical options for dogs with distal radial osteosarcoma (OSA). This case report highlights the novel application of a three-dimensional (3D)-printed patient-specific polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) scaffold in limb-sparing surgery in a dog with distal radial OSA. The outcomes evaluated included postoperative gait analysis, complications, local recurrence of tumor, metastasis, and survival time. Post-operative gait evaluation showed significant improvement in limb function, including increased weight distribution and decreased asymmetry. The implant remained well in place and increased bone opacity was observed between the host bone and the scaffold. There was no complication due to scaffold or surgery. Significant improvement in limb function and quality of life was noted postoperatively. Local recurrence and pulmonary metastasis were identified at 8 weeks postoperatively. The survival time from diagnosis of OSA to death was 190 days. The PCL/β-TCP scaffold may be an effective alternative to cortical allograft in limb-sparing surgery for bone tumors.
Keywords: osteosarcoma, Limb-sparing, polycaprolactone/β-tricalcium phosphate, three-dimensional-printed scaffold
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