Crystal Structures of Some 2-Alkoxybenzamides

¹ Faculty of Engineering, UAE University, Al Ain, Abu, Dhabi, UAE
² Department of Inorganic Chemistry, University of Hamburg, D-20146 Hamburg, Germany
³ Agilent Technologies UK, Oxford, UK
⁴ Department of Chemistry, UAE University, Al Ain, Abu Dhabi, UAE

Published: 30 October 2012 by MDPI in The 16th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-16-01106

Abstract: o-Alkoxybenzamides are known to have biological activity. Thus, a group of o-methoxybenzamides constitutes dopamine receptor antagonists. Others, such as o-hexyloxybenzamide, have been found to have antifungal activity. In our search for cocrystal formation utilizing benzamides with the aim of improving solubility, stability and bioavailability during application of the molecules, we have first looked at the single crystal X-ray structures of the three o-alkoxybenzamides, o-allyloxybenzamide (1), o-propoxybenzamide (2), and o-pentoxybenzamide (3).

Keywords: o-alkoxybenzamides, O-alkylation, crystal structure, intermolecular bonding networks

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Bernhard Bugenhagen