Nanoporous heterogeneous catalysts have been applied in many reactions due to the high contact area and orderly porous structures with thermal, chemical and mechanical stability [1]. Pyrroles and their derivatives are one of the most important classes of heterocyclic compounds [2]. A four-component coupling reaction (4cr) consisted of aldehydes 1, amines 2, 1, 3 -dicarbonyl compounds 3 and nitromethane 4 afforded substituted pyrroles 5, using MCM-41-SO3H as heterogeneous catalyst. We investigated the synthesis of pyrrole derivatives in the solvent-free conditions. Products were obtained in good yields and short times.