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Preliminary Study of Photosynthesis-Inhibiting Activity of Substituted Phenylcarbamoylphenyl N-alkylcarbamates
Jarmila Vinsova 1 , Juana Monreal Ferriz 1 , Katarina Kralova 2 , Matus Pesko 3 , Josef Jampilek * 4, 5 , Ales Imramovsky * 6
1  Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, 500 05 Hradec Kralove, Czech Republic
2  Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 84215 Bratislava, Slovakia
3  Department of Ecosozology and Physiotactics, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 84215 Bratislava, Slovakia
4  Zentiva a.s., U kabelovny 130, 102 37 Prague 10, Czech Republic
5  Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech Republic
6  Institute of Organic Chemistry and Technology, Faculty of Chemistry and Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic

10.3390/ecsoc-14-00375
Abstract: In this study, a series of nine 4-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl N-alkylcarbamates was prepared. The procedures for synthesis of the compounds are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. For the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed, as well as their structure-activity relationships (SAR).
Keywords: 4-Chloro-2-(3,4-dichlorophenylcarbamoyl)-phenyl N-alkylcarbamates; Lipophilicity; PET inhibition; Spinach chloroplasts; Structure-activity relationships

 
 
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