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In vitro Antimicrobial activity of Newly Synthesized Monoazaphenothiazine Derivatives.
AGBO STEPHEN ATTAH
* 1 ,
SWANDE PETER IOREMBER
2 ,
ANOH VITALIS AONDOAVER
1
1  Organic Chemistry Unit, Department of Chemistry, Faculty of Science, Benue State University, Makurdi, Nigeria
2  Department of Basic Sciences, Akperan Orshi College of Agriculture, Yandev, Gboko, Nigeria
Published: 03 November 2017 by MDPI in The 21st International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry
https://doi.org/10.3390/ecsoc-21-04715
Abstract:

Abstract                                                                                                                                                                                                                                                                                                 The antimicrobial activity of newly synthesized linear monoazaphenothiazine derivatives; 3-benzamido-1-azaphenothiazine, 3-trifluoromethamido-1-azaphenothiazine, 3-trichloromethanamido-1-azaphenothiazine and 3-(4-nitrobenzamido)-1- azaphenothiazine have been evaluated against bacteria and fungal strains.  Results showed that most of the synthesized linear monoazaphenothiazine derivatives were significantly active against the tested microorganisms. The correlation between antimicrobial activity and the chemical structure of phenothiazines was discussed.

Keywords: Keywords: Antimicrobial, monoazaphenothiazine, phenothiazine, microorganisms, structure –activity relationship.
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