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NMR analysis of a new canthin-6-one alkaloid from Simaba bahiensis (Simaroubaceae)
Rafael Costa 1 , Dara Fontes 2 , Lucas Abreu 3 , Josean Tavares 3 , Eudes Velozo 4

1  Chemistry Insitute, Federal University of Bahia, Brazil
2  Faculty of Pharmacy, Federal University of Bahia, Brazil
3  Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos, Federal University of Paraíba, Paraíba, Brazil
4  Chemistry Insitute, Federal University of Bahia, Brazil,Faculty of Pharmacy, Federal University of Bahia, Brazil

Published: 05 December 2017 by MDPI AG in MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd edition in MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd edition
MDPI AG, 10.3390/mol2net-03-05056
Abstract:

Alkaloids of the canthi-6-one type have been reported in differents natural sources. These alkaloids have showed a wide range of pharmacological properties including cytotoxic, antibacterial, antifungal, antiparasict, antiviral, anti-inflammatory and beside it, some of them show excellent photophysical properties that gives an interesting use as fluorescent dye probe in florescent cellular microscopy. Because it, new studies have been carrying out in an attempt to identify new alkaloids with pharmacological properties. Some researchers have been trying to synthesize new derivatives or identify new compounds in natural sources. Among the >60 canthin-6-one alkaloids already reported in natural sources, more the half are present in plants of the family Simaroubaceae. In the Simaba genus, up to the present, only eighteen alkaloids was described in seven species, but other plants of the genus that occur in the brazilian’s flora haven’t been studied yet. In this work we describe the first phytochemical study of the specie Simaba bahiensis (Simaroubaceae), collected at the city of Camaçari, Bahia State, Brazil. Also, it’s related complete structural determination using differents NMR experiments and HRMS of a new canthin-6-one alkaloid in addition to two others already known.


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