Synthesis of hardly available 2-alkylsemicarbazides and their hydrochlorides from semicarbazide hydrochloride has been developed. This general and efficient protocol is based on preparation of acetone semicarbazone, its N2-alkylation in the presence of sodium hydride, and hydrolysis under mild conditions.
A new efficient route to 2-alkylsemicarbazides
Published: 14 November 2019 by MDPI AG in The 23rd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
10.3390/ecsoc-23-06501 (registering DOI)
Keywords: Semicarbazides, semicarbazones, alkylation, hydrolysis