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Papers from Scilit (117 620 423)
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Editorial Board
Published: 20 April 2019 by Elsevier BV in Electrochimica Acta
Elsevier BV, Volume 303; 10.1016/s0013-4686(19)30446-3
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Future SI
Published: 20 April 2019 by Elsevier BV in Electrochimica Acta
Elsevier BV, Volume 303; 10.1016/s0013-4686(19)30449-9
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Published: 20 April 2019 by Elsevier BV in Progress in Neuro-Psychopharmacology and Biological Psychiatry
Elsevier BV, Volume 91; 10.1016/s0278-5846(19)30189-7
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Published: 20 April 2019 by Elsevier BV in Construction and Building Materials
Elsevier BV, Volume 204; 10.1016/s0950-0618(19)30623-3
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Risk of bleeding in patients with continued dual antiplatelet therapy during orthopedic surgery.
San-Bao Hu, Yong Hai, Jie-Fu Tang, Tao Liu, Bing-Xin Liang, Bo-Qiong Xue
Published: 20 April 2019 by Ovid Technologies (Wolters Kluwer Health) in Chinese Medical Journal
Ovid Technologies (Wolters Kluwer Health), Volume 132; 10.1097/CM9.0000000000000186
To prevent risk of life-threatening stent thrombosis, all patients need to undergo dual antiplatelet therapy (DAPT) for at least 6 weeks to 12 months after stent implantation. If DAPT is continued during noncardiac surgery, there is a risk of severe bleeding at the surgical site. Our study was to assess the risk of bleeding in patients with continued DAPT during orthopedic surgery. The clinical data of 78 patients with coronary heart disease who underwent orthopedic surgery from February 2006 to July 2018 were retrospectively analyzed. Prior to orthopedic surgery, DAPT was continued in 16 patients (group I), 24 patients were treated with single antiplatelet therapy (group II), and 26 patients received low-molecular-weight heparin therapy for more than 5 days after the discontinuation of all antiplatelet therapies (group III). Twelve patients were excluded, as they had undergone minimally invasive surgery such as transforaminal endoscopy and vertebroplasty. The perioperative blood loss of each patient was calculated using Nadler's formula and Gross' formula. The intraoperative bleeding volume, total volume of intraoperative bleeding in addition to postoperative drainage, and total blood loss were compared between groups. The level of significance was set at P < 0.05. There were no significant differences between the three groups in age, intraoperative bleeding volume, total volume of intraoperative bleeding in addition to postoperative drainage, and total perioperative blood loss calculated by Nadler's formula and Gross' formula (all P > 0.05). Six patients experienced postoperative cardiovascular complications due to the delayed restart of antiplatelet therapy; one of these patients in group III died from myocardial infarction. Continued DAPT or single antiplatelet treatment during orthopedic surgery does not increase the total intraoperative and perioperative bleeding compared with switching from antiplatelet therapy to low-molecular-weight heparin. However, the discontinuation of antiplatelet therapy increases the risk of serious cardiac complications.
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Published: 20 April 2019 by Elsevier BV in International Journal of Pharmaceutics
Elsevier BV, Volume 561; 10.1016/s0378-5173(19)30240-6
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Published: 20 April 2019 by Elsevier BV in Tectonophysics
Elsevier BV, Volume 757; 10.1016/s0040-1951(19)30129-5
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Conclusion:
Published: 20 April 2019 by JSTOR in Kwame Nkrumah and the Dawn of the Cold War
JSTOR, 10.2307/j.ctvfp635j.12
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Introduction
Published: 20 April 2019 by JSTOR in The Educated Underclass
JSTOR, 10.2307/j.ctvfp63kb.6
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Preface
Published: 20 April 2019 by JSTOR in The Educated Underclass
JSTOR, 10.2307/j.ctvfp63kb.5
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