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Huangxian Ju   Professor  Senior Scientist or Principal Investigator 
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Huangxian Ju published an article in April 2019.
Research Keywords & Expertise
0 A
0 Fluorescence
0 Nanoparticles
0 Sensors
0 immunoassay
Top co-authors See all
Chao-Jun Li

638 shared publications

Department of Chemistry and FRQNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street W., Montreal, Quebec H3A 0B8, Canada

Jianping Lei

168 shared publications

State Key Laboratory of Analytical Chemistry for Life ScienceSchool of Chemistry and Chemical EngineeringNanjing University Nanjing 210023 China

Qing Jiang

113 shared publications

State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China

Minghao Zheng

85 shared publications

Centre for Orthopaedic Research, Faculty of Health and Medical Sciences, The University of Western Australia, Nedlands, WA, Australia

Yi Cao

80 shared publications

Collaborative Innovation Center of Advanced MicrostructuresNational Laboratory of Solid State Microstructure, Department of PhysicsNanjing University Nanjing 210093 P.R. China

Publication Record
Distribution of Articles published per year 
(2003 - 2019)
Total number of journals
published in
Publications See all
Article 0 Reads 0 Citations A sandwich-type photoelectrochemical immunosensor for NT-pro BNP detection based on F-Bi2WO6/Ag2S and GO/PDA for signal ... Yanrong Qian, Jinhui Feng, Dawei Fan, Yong Zhang, Xuan Kuang... Published: 01 April 2019
Biosensors and Bioelectronics, doi: 10.1016/j.bios.2019.02.029
DOI See at publisher website
Article 0 Reads 0 Citations Cobalt-based metal-organic frameworks as co-reaction accelerator for enhancing electrochemiluminescence behavior of N-(a... Chao Wang, Nuo Zhang, Yueyuan Li, Lei Yang, Dong Wei, Tao Ya... Published: 01 April 2019
Sensors and Actuators B: Chemical, doi: 10.1016/j.snb.2019.04.097
DOI See at publisher website ABS Show/hide abstract
In this work, a “luminophore/coreactant/co-reaction accelerator” ternary electrochemiluminescence (ECL) system is proposed by using N-(aminobutyl)-N-(ethylisoluminol) (ABEI) functionalized cobalt-based MOFs (Co-MOFs/ABEI) with superior peroxidase-like activities as the luminophore. ABEI, the derivative of luminol, is used as the reductant and organic ligand to synthesize flower-like Co-MOFs/ABEI. The as-synthesized Co-MOFs/ABEI not only function as desirable nano-carriers for the enrichment of ABEI, but also act as co-reaction accelerators for the catalysis of H2O2 decomposition. Furthermore, Au nanoparticles are decorated on Co-MOFs/ABEI via electrostatics attraction, endowing it with favorable biocompatibility and electrocatalytic property to bond with detection antibodies and generate more excited state ABEI*. Besides, with the advantages of large specific surface area and easy preparation, Au nanoparticles functionalized [email protected] is utilized to anchor the capture antibodies for immunoaction with target analyte. Amyloid-β protein (Aβ42), a principal hallmark of Alzheimer’s disease, is chosen as the target analyte. The proposed Aβ42 immunosensor performs with a broad linear range from 10 fg·mL-1 to 100 ng·mL-1 and a detection limit down to 3 fg·mL-1, opens up new prospects for clinical analysis of Aβ42 and provides promising approaches to synthesize luminophore-functionalized MOFs with high luminous efficiency for ECL bioanalysis.
Article 0 Reads 0 Citations Bubble-Propelled Jellyfish-like Micromotors for DNA Sensing Xueqing Zhang, Chengtao Chen, Jie Wu, Huangxian Ju Published: 19 March 2019
ACS Applied Materials & Interfaces, doi: 10.1021/acsami.9b00605
DOI See at publisher website
Article 0 Reads 0 Citations Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading ... Jin Dai, Sheng Zhou, Qiting Ge, Jinzhong Qin, Jianxin Li, Hu... Published: 20 February 2019
Journal of Orthopaedic Surgery and Research, doi: 10.1186/s13018-019-1091-3
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Proinflammatory cytokines, which can upregulate the expression of matrix-degrading enzymes in chondrocytes, play important roles in the development of osteoarthritis. BET family proteins, acting as the "readers" of acetylated modifications on histones, have been linked to transcriptional regulation. And a BET protein inhibitor, I-BET151, has been shown to inhibit the induction of matrix-degrading enzymes by proinflammatory cytokines in chondrocytes. Our objective is to clarify the role and mechanism of BET proteins on matrix-degrading enzyme gene expression by using a human chondrosarcoma cell line (SW1353). We pretreated SW1353 cells with I-BET151 prior to treatment with IL-1β or TNF-α and then checked the expression of four matrix-degrading enzyme genes (MMP1, MMP3, MMP13, and ADAMTS4). We performed knockdown of BET protein family members (BRD2, BRD3, and BRD4) with corresponding siRNAs in SW1353 cells prior to treatment with IL-1β or TNF-α and checked the expression of the matrix-degrading enzyme genes. We evaluated Brd-mediated transcriptional regulation on the matrix-degrading enzyme genes by ChIP assay. We confirmed that I-BET151 could suppress the IL-1β- or TNF-α-induced expression of MMP1, MMP3, MMP13, and ADAMTS4 in SW1353 cells. Brd3 and Brd4 were required for the IL-1β- or TNF-α-induced expression of matrix-degrading enzyme genes in SW1353 cells. We revealed that inducible acetylation of H4k5/8/12 and the recruitment of Brd3, Brd4, and p-TEFb to chromatin were involved in IL-1β- or TNF-α-induced transcription. Our findings suggested that Brd3 and Brd4 were essential for the IL-1β- or TNF-α-induced transcription of matrix-degrading enzyme genes, and recruitment of Brd3 and Brd4 to chromatin of these genes played the main role in this process.
Article 0 Reads 0 Citations Nanoamplicon Comparator for Live-Cell MicroRNA Imaging Min Huo, Siqiao Li, Peiwen Zhang, Yimei Feng, Yiran Liu, Na ... Published: 08 February 2019
Analytical Chemistry, doi: 10.1021/acs.analchem.8b04661
DOI See at publisher website
Article 0 Reads 0 Citations A rolling circle amplification-assisted DNA walker triggered by multiple DNAzyme cores for highly sensitive electrochemi... Sina Wang, Yuhang Ji, Haomin Fu, Huangxian Ju, Jianping Lei Published: 01 January 2019
The Analyst, doi: 10.1039/c8an01892h
DOI See at publisher website