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Andrea Haase      
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Andrea Haase published an article in July 2018.
Top co-authors See all
Kenneth A. Dawson

271 shared publications

Centre for BioNano Interactions, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland

Lang Tran

202 shared publications

Macao Sino-Portuguese Nurses Association; Macao China

Andreas Taubert

143 shared publications

Institute of Chemistry, University of Potsdam, D-14476 Potsdam, Germany

Iseult Lynch

129 shared publications

School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, UK

Wendel Wohlleben

95 shared publications

BASF SE, Advanced Materials Research, 67056 Ludwigshafen, Germany

Publication Record
Distribution of Articles published per year 
(2012 - 2018)
Total number of journals
published in
Publications See all
Article 0 Reads 0 Citations Quality in nanosafety — Towards reliable nanomaterial safety assessment Andrea Haase, Iseult Lynch Published: 01 July 2018
NanoImpact, doi: 10.1016/j.impact.2018.02.005
DOI See at publisher website
Article 1 Read 0 Citations Quantification of silver nanoparticles taken up by single cells using inductively coupled plasma mass spectrometry in th... Ana López-Serrano Oliver, Sabine Baumgart, Wolfram Bremser, ... Published: 01 January 2018
Journal of Analytical Atomic Spectrometry, doi: 10.1039/c7ja00395a
DOI See at publisher website ABS Show/hide abstract
A promising analytical methodology is proposed to study nanoparticle-cell interactions providing information of the number of NPs internalized by cells or externally bound to the cell surface.
Article 4 Reads 3 Citations Benchmark of Nanoparticle Tracking Analysis on Measuring Nanoparticle Sizing and Concentration Ciaran Manus Maguire, Katherine Sillence, Claire Hannell, Gu... Published: 28 September 2017
Journal of Micro and Nano-Manufacturing, doi: 10.1115/1.4037124
DOI See at publisher website
Article 5 Reads 3 Citations CompNanoTox2015: novel perspectives from a European conference on computational nanotoxicology on predictive nanotoxicol... Miguel A. Bañares, Andrea Haase, Lang Tran, Vladimir Lobaski... Published: 09 August 2017
Nanotoxicology, doi: 10.1080/17435390.2017.1371351
DOI See at publisher website PubMed View at PubMed
Article 4 Reads 4 Citations Genotoxicity testing of different surface-functionalized SiO2, ZrO2 and silver nanomaterials in 3D human bronchial model... Andrea Haase, Nils Dommershausen, Markus Schulz, Robert Land... Published: 22 June 2017
Archives of Toxicology, doi: 10.1007/s00204-017-2015-9
DOI See at publisher website PubMed View at PubMed
Article 1 Read 4 Citations Quantification of silver nanoparticle uptake and distribution within individual human macrophages by FIB/SEM slice and v... Erik Guehrs, Michael Schneider, Christian M. Günther, Piet H... Published: 21 March 2017
Journal of Nanobiotechnology, doi: 10.1186/s12951-017-0255-8
DOI See at publisher website ABS Show/hide abstract
Background Quantification of nanoparticle (NP) uptake in cells or tissues is very important for safety assessment. Often, electron microscopy based approaches are used for this purpose, which allow imaging at very high resolution. However, precise quantification of NP numbers in cells and tissues remains challenging. The aim of this study was to present a novel approach, that combines precise quantification of NPs in individual cells together with high resolution imaging of their intracellular distribution based on focused ion beam/ scanning electron microscopy (FIB/SEM) slice and view approaches. Results We quantified cellular uptake of 75 nm diameter citrate stabilized silver NPs (Ag 75 Cit) into an individual human macrophage derived from monocytic THP-1 cells using a FIB/SEM slice and view approach. Cells were treated with 10 μg/ml for 24 h. We investigated a single cell and found in total 3138 ± 722 silver NPs inside this cell. Most of the silver NPs were located in large agglomerates, only a few were found in clusters of fewer than five NPs. Furthermore, we cross-checked our results by using inductively coupled plasma mass spectrometry and could confirm the FIB/SEM results. Conclusions Our approach based on FIB/SEM slice and view is currently the only one that allows the quantification of the absolute dose of silver NPs in individual cells and at the same time to assess their intracellular distribution at high resolution. We therefore propose to use FIB/SEM slice and view to systematically analyse the cellular uptake of various NPs as a function of size, concentration and incubation time. Keywords Nanoparticles FIB/SEM slice and view Absolute dose Cellular internalization Macrophage