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Stefan Lang      
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Stefan Lang published an article in January 2018.
Top co-authors See all
X. Jing

264 shared publications

Beijing University of Posts and Telecommunications, Beijing, Beijing, CHINA

Dirk Tiede

56 shared publications

Department of Geoinformatics – Z_GIS, University of Salzburg, Salzburg, Austria

Ola Hansson

49 shared publications

Lund University Diabetes Center, Malmo

C. M. Cilio

48 shared publications

Cellular Autoimmunity Unit; Department of Clinical Sciences; Skåne University Hospital; Lund University; Malmo Sweden

Enming Zhang

39 shared publications

School of Materials Science and Engineering

11
Publications
4
Reads
0
Downloads
57
Citations
Publication Record
Distribution of Articles published per year 
(1970 - 2018)
Total number of journals
published in
 
7
 
Publications See all
BOOK-CHAPTER 1 Read 0 Citations Earth Observation for Humanitarian Operations Stefan Lang, Petra Füreder, Edith Rogenhofer Published: 01 January 2018
The Yearbook on Space Policy, doi: 10.1007/978-3-319-72465-2_10
DOI See at publisher website
Article 0 Reads 0 Citations Urban green valuation integrating biophysical and qualitative aspects Stefan Lang Published: 12 December 2017
European Journal of Remote Sensing, doi: 10.1080/22797254.2017.1409083
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Urban green mapping has become an operational task in city planning, urban land management, and quality of life assessments. As a multi-dimensional, integrative concept, urban green comprising several ecological, socio-economic, and policy-related aspects. In this paper, the author advances the representation of urban green by deriving scale-adapted, policy-relevant units. These so-called geons represent areas of uniform green valuation under certain size and homogeneity constraints in a spatially explicit representation. The study accompanies a regular monitoring scheme carried out by the urban municipality of the city of Salzburg, Austria, using optical satellite data. It was conducted in two stages, namely SBG_QB (10.2 km², QuickBird data from 2005) and SBG_WV (140 km², WorldView-2 data from 2010), within the functional urban area of Salzburg. The geon delineation was validated by several quantitative measures and spatial analysis techniques, as well as ground documentation, including panorama photographs and visual interpretation. The spatial association pattern was assessed by calculating Global Moran’s I with incremental search distances. The final geonscape, consisting of 1083 units with an average size of 13.5 ha, was analyzed by spatial metrics. Finally, categories were derived for different types of functional geons. Future research paths and improvements to the described strategy are outlined.
BOOK-CHAPTER 0 Reads 0 Citations Land Use/Land Cover Classification of the Natural Environment Rajesh Thapa, Stefan Lang, Elisabeth Schoepfer, Stefan Kienb... Published: 01 January 2015
Applied Geoinformatics for Sustainable Integrated Land and Water Resources Management (ILWRM) in the Brahmaputra River basin, doi: 10.1007/978-81-322-1967-5_5
DOI See at publisher website
Article 0 Reads 5 Citations The Nuclear Localization of γ-Tubulin Is Regulated by SadB-mediated Phosphorylation Greta Eklund, Stefan Lang, Johan Glindre, Maria Alvarado-Kri... Published: 18 June 2014
Journal of Biological Chemistry, doi: 10.1074/jbc.m114.562389
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Article 0 Reads 20 Citations Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway Yuedan Zhou, Enming Zhang, Christine Berggreen, Xingjun Jing... Published: 30 September 2011
Human Molecular Genetics, doi: 10.1093/hmg/ddr454
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The transcription factor T-cell factor 7-like 2 (TCF7L2) confers type 2 diabetes risk mainly through impaired insulin secretion, perturbed incretin effect and reduced beta-cell survival. The aim of this study was to identify the molecular mechanism through which TCF7L2 influences beta-cell survival. TCF7L2 target genes in INS-1 cells were identified using Chromatin Immunoprecipitation. Validation of targets was obtained by: siRNA silencing, real-time quantitative polymerase chain reaction, electrophoretic mobility shift assay, luciferase reporter assays and western blot. Apoptosis rate was measured by DNA degradation and caspase-3 content. Islet viability was estimated by measuring metabolic rate. TCF7L2 binds to 3646 gene promoters in INS-1 cells in high or low glucose, including Tp53, Pten, Uggt1, Adamts9 and Fto. SiRNA-mediated reduction in TCF7L2 activity resulted in increased apoptosis and increased expression of Tp53, which resulted in elevated p53 protein activity and an increased expression of the p53 target gene Tp53inp1 (encoding p53-induced-nuclear-protein 1). Reversing the increase in p53INP1 protein expression, seen after Tcf7l2 silencing, protected INS-1 cells from Tcf7l2 depletion-induced apoptosis. This result was replicated in primary rat islets. The risk T-allele of rs7903146 is associated with increased TCF7L2 mRNA expression and transcriptional activity. On the other hand, in vitro silencing of TCF7L2 lead to increased apoptosis. One possibility is that the risk T-allele increases expression of an inhibitory TCF7L2 isoform with lower transcriptional activity. These results identify the p53-p53INP1 pathway as a molecular mechanism through which TCF7L2 may affect beta-cell survival and established a molecular link between Tcf7l2 and two type 2 diabetes-associated genes, Tp53inp1 and Adamts9.
BOOK-CHAPTER 2 Reads 2 Citations Segmentation and Object-Based Image Analysis Elisabeth Schöpfer, Stefan Lang, Josef Strobl Published: 01 January 2010
Remote Sensing and Digital Image Processing, doi: 10.1007/978-1-4020-4385-7_10
DOI See at publisher website
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