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Randolph Arroo   Dr.  Senior Scientist or Principal Investigator 
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Randolph Arroo published an article in July 2018.
Top co-authors See all
Bilal Haider Abbasi

161 shared publications

Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan

Mercedes Bonfill

80 shared publications

Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain

Roberta Budriesi

79 shared publications

Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro, 6, 40126 Bologna, Italy.

Eric Gontier

45 shared publications

Unité de Recherche EA3900 BIOPI-UPJV Biologie des plantes et Innovation, Université de Picardie Jules Verne, UFR des Sciences, Ilot des poulies, 33 rue Saint Leu, 80039 Amiens Cedex 1 - France

Mohammad Hossein Mirjalili

32 shared publications

Department of Agriculture, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Tehran, Iran

Publication Record
Distribution of Articles published per year 
(1990 - 2018)
Total number of journals
published in
Publications See all
Article 0 Reads 1 Citation Chemical properties of thymoquinone, a monoterpene isolated from the seeds of Nigella sativa Linn. Randolph R.J. Arroo, Hajara H. Alfa Published: 01 July 2018
Pharmacological Research, doi: 10.1016/j.phrs.2018.05.003
DOI See at publisher website
Article 0 Reads 1 Citation Investigation of Linum flavum (L.) Hairy Root Cultures for the Production of Anticancer Aryltetralin Lignans Sullivan Renouard, Cyrielle Corbin, Samantha Drouet, Barbara... Published: 26 March 2018
International Journal of Molecular Sciences, doi: 10.3390/ijms19040990
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Linum flavum hairy root lines were established from hypocotyl pieces using Agrobacterium rhizogenes strains LBA 9402 and ATCC 15834. Both strains were effective for transformation but induction of hairy root phenotype was more stable with strain ATCC 15834. Whereas similar accumulation patterns were observed in podophyllotoxin-related compounds (6-methoxy-podophyllotoxin, podophyllotoxin and deoxypodophyllotoxin), significant quantitative variations were noted between root lines. The influence of culture medium and various treatments (hormone, elicitation and precursor feeding) were evaluated. The highest accumulation was obtained in Gamborg B5 medium. Treatment with methyl jasmonate, and feeding using ferulic acid increased the accumulation of aryltetralin lignans. These results point to the use of hairy root culture lines of Linum flavum as potential sources for these valuable metabolites as an alternative, or as a complement to Podophyllum collected from wild stands.
Article 0 Reads 1 Citation Anticancer Potential of Flavones Randolph R. J. Arroo, Didem Şöhretoğlu, Demetrios A. Spandid... Published: 17 November 2017
Proceedings, doi: 10.3390/proceedings1100975
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Many papers have been written on the anticancer properties of dietary flavonoids, and a range of potential mechanisms of action of flavonoids. However, most dietary flavonoids - notably polyphenolic flavonoids—have very poor ADME properties, and the levels necessary to stop growth of tumour cells cannot be sustained in a human body trough dietary intake alone. At present no flavonoid based drugs are clinically used in cancer therapy. Thus, whereas epidemiological and pre-clinical data seem to indicate a high potential for flavonoids, from the point of view of the pharmaceutical industry and drug developers, they are considered poor candidates. The flavones—which constitute a subgroup of the flavonoids—show some structural analogy with oestrogen and are known to interact with human oestrogen receptors, either as agonist or as antagonist. They are classed as phytoestrogens, and may play a role in cancer prevention through a mechanism of action possibly similar to that of the clinically used medication tamoxifen. Flavones are abundantly present in common fruits and vegetables, many of which have been associated with cancer prevention. Their phytoestrogen activity makes that they can assert their biological action at concentrations that are realistically achievable in the human systemic circulation.
Article 0 Reads 2 Citations Flavonoids and Their Metabolites: Prevention in Cardiovascular Diseases and Diabetes Keti Zeka, Ketan Ruparelia, Randolph R. J. Arroo, Roberta Bu... Published: 05 September 2017
Diseases, doi: 10.3390/diseases5030019
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The occurrence of atherosclerosis and diabetes is expanding rapidly worldwide. These two metabolic disorders often co-occur, and are part of what is often referred to as the metabolic syndrome. In order to determine future therapies, we propose that molecular mechanisms should be investigated. Once the aetiology of the metabolic syndrome is clear, a nutritional intervention should be assessed. Here we focus on the protective effects of some dietary flavonoids, and their metabolites. Further studies may also pave the way for development of novel drug candidates.
BOOK-CHAPTER 0 Reads 0 Citations Biotechnological Approaches for Bioremediation: In Vitro Hairy Root Culture Sonia Malik, Sara Adrián L. Andrade, Mohammad Hossein Mirjal... Published: 09 May 2017
Reference Series in Phytochemistry, doi: 10.1007/978-3-319-28669-3_28
DOI See at publisher website
BOOK-CHAPTER 0 Reads 0 Citations Biotechnological Approaches for Bioremediation: In Vitro Hairy Root Culture Sonia Malik, Sara Adrián L. Andrade, Mohammad Hossein Mirjal... Published: 09 August 2016
Reference Series in Phytochemistry, doi: 10.1007/978-3-319-27490-4_28-1
DOI See at publisher website