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Gou-Jen Wang published an article in May 2018.
Top co-authors See all
186 shared publications
98 shared publications
J. H. Liu
97 shared publications
J. G. Sun
86 shared publications
China Pharmaceutical University
68 shared publications
Department of Mechanical Engineering, National Chung‐Hsing University, Taichung, Taiwan
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(1999 - 2018)
(1999 - 2018)
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Article 0 Reads 0 Citations Design and manufacture of high-filling-efficiency microfluidic devices Published: 01 May 2018
The International Journal of Advanced Manufacturing Technology, doi: 10.1007/s00170-018-2039-1
In this study, we proposed an efficient method for mass production of high-filling-efficiency microfluidic devices. Precision machining was the main process of device fabrication. The commercially available SolidWorks software was adopted for structure design. Unigraphics software was then used to simulate the machining process. The simulated tooling file was then loaded into a CNC milling machine for mold production. The fabricated metal mold was used for pouring polydimethylsiloxane (PDMS) to obtain high-filling-efficiency microfluidic structures. Finally, plasma-assisted packaging was conducted to tightly bind the PDMS microfluidic structure to the glass substrate. Experimental results showed that the additional semicircular filling structure and expended fill-entry structure can efficiently enhance filling efficiency of the microchannel device. The incubation well array can be completely filled at a relatively short filling time. The proposed highly efficient filling microfluidic device possesses advantages, such as feasibility for mass production and cost effectiveness.
Article 1 Read 0 Citations Using Anodic Aluminum Oxide Film and Nanoimprint to Produce Polymer Anti-counterfeit Labels Published: 06 June 2017
Smart Science, doi: 10.1080/23080477.2017.1336153
Article 2 Reads 0 Citations An endothelial cultured condition medium embedded porous PLGA scaffold for the enhancement of mouse embryonic stem cell ... Published: 12 April 2016
Biomedical Materials, doi: 10.1088/1748-6041/11/2/025015
In this study, we have developed a microporous poly(lactic-co-glycolic acid) (PLGA) scaffold that combines a continuous release property and a three-dimensional (3D) scaffolding technique for the precise and efficient formation of endothelial cell lineage from embryonic stem cells (ESCs). Eight PLGA scaffolds (14.29%, 16.67%, 20% and 25% concentrations of PLGA solutions) mixed with two crystal sizes of sodium chloride (NaCl) were fabricated by leaching. Then, vascular endothelial cell conditioned medium (ECCM) mixed with gelatin was embedded into the scaffold for culturing of mouse embryonic stem cells (mESCs). The 14.29% PLGA scaffolds fabricated using non-ground NaCl particles (NG-PLGA) and the 25% PLGA containing scaffolds fabricated using ground NaCl particles (G-PLGA) possessed minimum and maximum moisture content and bovine serum albumin (BSA) content properties, respectively. These two groups of scaffolds were used for future experiments in this study. Cell culture results demonstrated that the proposed porous scaffolds without growth factors were sufficient to induce mouse ESCs to differentiate into endothelial-like cells in the early culture stages, and combined with embedded ECCM could provide a long-term inducing system for ESC differentiation.
Article 2 Reads 0 Citations Pelvic-perineal reconstruction with the combined transverse upper gracilis and profunda artery perforator (TUG-PAP) flap Published: 01 April 2016
Journal of Plastic, Reconstructive & Aesthetic Surgery, doi: 10.1016/j.bjps.2015.11.019
The goals of pelvic-perineal reconstruction are to provide stable coverage while ensuring containment of the peritoneal contents and obliteration of dead space to prevent herniation and infection respectively. The vertical rectus abdominis muscle (VRAM) flap has traditionally been favoured due to its large bulk and ease of transfer.1 However, when the abdomen is not available as a donor site, secondary sites need to be considered. The gracilis muscle or musculocutaneous flap has been used as a pedicled flap for perineal reconstruction.
Article 1 Read 0 Citations A nano/micro hybrid structures for enhancing B35 cell guidance on chitosan Published: 17 March 2016
J Nanotechnol Eng Med, doi: 10.1115/1.4032602
A novel chitosan scaffold with micro and nano hybrid structures were proposed. The hemispheric array of the barrier layer of an anodic aluminum oxide film was used as the substrate. Microelectromechanical systems and nickel electroforming techniques were integrated for fabricating chitosan scaffolds with different micro/nano hybrid structures. Nerve cells were then cultured on the conduits. The scaffold with pure microstructures can only guide the nerve cells to grow along the ridges of the microstructure, and some cells grow across the groove in between two ridges of the microstructure. However, the scaffold with microscale ridges and nanopatterns on the groove between two ridges can more effectively guide the cells to grow along the ridges, thus enhancing the proliferation of nerve cells.
Article 0 Reads 3 Citations Design of microplasma electrodes for plasma-on-chip devices Published: 14 March 2016
Journal of Physics D: Applied Physics, doi: 10.1088/0022-3727/49/15/155203
Plasma-on-chip (POC) devices have been developed to achieve plasma treatment of individual cells. However, the microcathode of a POC can be easily damaged during plasma firing. In this study, microplasma electrodes for POC devices were designed to enhance the lifetime of plasma electrodes while maintaining their microplasma characteristics. An electrode comprising a 20 nm-thick titanium layer and a 200 nm-thick gold layer on a silicon substrate was fabricated by photolithography and evaporation. Experimental results illustrated that a microelectrode with a blunt-ended cathode and a flat anode can extend the firing lifetime by as much as 30 times that of a double-tip electrode. We also fabricated a 220 nm-thick pure titanium electrode to further extend the lifetime of the electrode. Experimental results showed that the pure titanium electrode can further extend the lifetime 60 fold when compared with an Au / Ti hybrid electrode. However, the voltage requirement for the pure titanium electrode is only 20 V higher than that for the Au/Ti electrode. The pure titanium microelectrode proposed in this study possesses several advantages such as low cost, simple fabrication, and high biocompatibility. Hence, it is highly feasible for POC applications.