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Kevin Duffy   Professor  Other 
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Kevin Duffy published an article in May 2018.
Top co-authors See all
Baohua Gu

162 shared publications

Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States

Ganesh K. Venayagamoorthy

158 shared publications

Real-Time Power & Intell. Syst. Lab., Clemson Univ., Clemson, SC, USA

Michael Darcy

149 shared publications

Division of Interventional Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO, U.S.A.

Nannan Liu

106 shared publications

College of Precision Instrument and Opto-electronics Engineering, Tianjin University, Key Laboratory of Optoelectronics Information Technology of Ministry of Education, Tianjin 300072, China

Victor A. Ferrari

99 shared publications

Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia

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Publication Record
Distribution of Articles published per year 
(1985 - 2018)
Total number of journals
published in
 
27
 
Publications See all
Article 0 Reads 0 Citations A lepidopteran (Imbrasia belina) might influence tree-grass balance of Colophospermum mopane savanna Kevin J. Duffy, Timothy G. O’Connor, Obiora C. Collins Published: 14 May 2018
Theoretical Ecology, doi: 10.1007/s12080-018-0379-y
DOI See at publisher website
Article 0 Reads 1 Citation Global pattern of plant utilization across different organisms: Does plant apparency or plant phylogeny matter? Xiaohua Dai, Wei Zhang, Jiasheng Xu, Kevin J. Duffy, Qingyun... Published: 14 March 2017
Ecology and Evolution, doi: 10.1002/ece3.2882
DOI See at publisher website
ABS Show/hide abstract
The present study is the first to consider human and nonhuman consumers together to reveal several general patterns of plant utilization. We provide evidence that at a global scale, plant apparency and phylogenetic isolation can be important predictors of plant utilization and consumer diversity. Using the number of species or genera or the distribution area of each plant family as the island “area” and the minimum phylogenetic distance to common plant families as the island “distance”, we fitted presence–area relationships and presence–distance relationships with a binomial GLM (generalized linear model) with a logit link. The presence–absence of consumers among each plant family strongly depended on plant apparency (family size and distribution area); the diversity of consumers increased with plant apparency but decreased with phylogenetic isolation. When consumers extended their host breadth, unapparent plants became more likely to be used. Common uses occurred more often on common plants and their relatives, showing higher host phylogenetic clustering than uncommon uses. On the contrary, highly specialized uses might be related to the rarity of plant chemicals and were therefore very species-specific. In summary, our results provide a global illustration of plant–consumer combinations and reveal several general patterns of plant utilization across humans, insects and microbes. First, plant apparency and plant phylogenetic isolation generally govern plant utilization value, with uncommon and isolated plants suffering fewer parasites. Second, extension of the breadth of utilized hosts helps explain the presence of consumers on unapparent plants. Finally, the phylogenetic clustering structure of host plants is different between common uses and uncommon uses. The strength of such consistent plant utilization patterns across a diverse set of usage types suggests that the persistence and accumulation of consumer diversity and use value for plant species are determined by similar ecological and evolutionary processes.
Article 0 Reads 2 Citations Model highlights likely long-term influences of mesobrowsers versus those of elephants on woodland dynamics Christopher A. J. O'kane, Kevin J. Duffy, Bruce R. Page, Dav... Published: 12 August 2013
African Journal of Ecology, doi: 10.1111/aje.12103
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Article 0 Reads 6 Citations Stable isotope turnover and variability in tail hairs of captive and free-ranging African elephants ( Loxodonta africana... Kevin J. Duffy, Julia A. Lee-Thorp, Jacqueline Codron, Kevin... Published: 01 March 2013
Canadian Journal of Zoology, doi: 10.1139/cjz-2012-0155
DOI See at publisher website
Article 0 Reads 5 Citations Effects of resource limitation on habitat usage by the browser guild in Hluhluwe-iMfolozi Park, South Africa Christopher A. J. O'kane, Kevin J. Duffy, Bruce R. Page, Dav... Published: 01 January 2013
Journal of Tropical Ecology, doi: 10.1017/s0266467413000035
DOI See at publisher website
Article 0 Reads 16 Citations Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury Pinelopi P. Kapitsinou, Mark Michael, Christina E. Swan, Kev... Published: 01 May 2012
American Journal of Physiology-Renal Physiology, doi: 10.1152/ajprenal.00667.2011
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PubMed View at PubMed
ABS Show/hide abstract
Acute kidney injury (AKI) due to ischemia is an important contributor to the progression of chronic kidney disease (CKD). Key mediators of cellular adaptation to hypoxia are oxygen-sensitive hypoxia-inducible factors (HIF), which are regulated by prolyl-4-hydroxylase domain (PHD)-containing dioxygenases. While activation of HIF protects from ischemic cell death, HIF has been shown to promote fibrosis in experimental models of CKD. The impact of HIF activation on AKI-induced fibrosis has not been defined. Here, we investigated the role of pharmacologic HIF activation in AKI-associated fibrosis and inflammation. We found that pharmacologic inhibition of HIF prolyl hydroxylation before AKI ameliorated fibrosis and prevented anemia, while inhibition of HIF prolyl hydroxylation in the early recovery phase of AKI did not affect short- or long-term clinical outcome. Therefore, preischemic targeting of the PHD/HIF pathway represents an effective therapeutic strategy for the prevention of CKD resulting from AKI, and it warrants further investigation in clinical trials.
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