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Jane Gallagher   Dr.  Research or Laboratory Scientist 
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Jane Gallagher published an article in July 2016.
Top co-authors See all
David Reif

102 shared publications

Center for Human Health and the Environment, and Department of Biological Sciences, North Carolina State University

Lucas M Neas

74 shared publications

National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, Durham, NC, USA

Haluk Özkaynak

58 shared publications

National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, USA

Ronald W Williams

48 shared publications

National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA

Elaine A Cohen Hubal

33 shared publications

Office of Research and Development, U.S. EPA, Research Triangle Park, North Carolina, USA

Publication Record
Distribution of Articles published per year 
(1999 - 2016)
Total number of journals
published in
Publications See all
Article 0 Reads 4 Citations Factors associated with self-reported health: implications for screening level community-based health and environmental ... Jane E. Gallagher, Adrien A. Wilkie, Edward E. Hudgens, Andr... Published: 26 July 2016
BMC Public Health, doi: 10.1186/s12889-016-3321-5
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Background Advocates for environmental justice, local, state, and national public health officials, exposure scientists, need broad-based health indices to identify vulnerable communities. Longitudinal studies show that perception of current health status predicts subsequent mortality, suggesting that self-reported health (SRH) may be useful in screening-level community assessments. This paper evaluates whether SRH is an appropriate surrogate indicator of health status by evaluating relationships between SRH and sociodemographic, lifestyle, and health care factors as well as serological indicators of nutrition, health risk, and environmental exposures. Methods Data were combined from the 2003–2006 National Health and Nutrition Examination Surveys for 1372 nonsmoking 20–50 year olds. Ordinal and binary logistic regression was used to estimate odds ratios and 95 % confidence intervals of reporting poorer health based on measures of nutrition, health condition, environmental contaminants, and sociodemographic, health care, and lifestyle factors. Results Poorer SRH was associated with several serological measures of nutrition, health condition, and biomarkers of toluene, cadmium, lead, and mercury exposure. Race/ethnicity, income, education, access to health care, food security, exercise, poor mental and physical health, prescription drug use, and multiple health outcome measures (e.g., diabetes, thyroid problems, asthma) were also associated with poorer SRH. Conclusion Based on the many significant associations between SRH and serological assays of health risk, sociodemographic measures, health care access and utilization, and lifestyle factors, SRH appears to be a useful health indicator with potential relevance for screening level community-based health and environmental studies.
Article 0 Reads 7 Citations Data-Driven Asthma Endotypes Defined from Blood Biomarker and Gene Expression Data Barbara Jane George, David M. Reif, Jane E. Gallagher, ClarL... Published: 02 February 2015
PLOS ONE, doi: 10.1371/journal.pone.0117445
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
The diagnosis and treatment of childhood asthma is complicated by its mechanistically distinct subtypes (endotypes) driven by genetic susceptibility and modulating environmental factors. Clinical biomarkers and blood gene expression were collected from a stratified, cross-sectional study of asthmatic and non-asthmatic children from Detroit, MI. This study describes four distinct asthma endotypes identified via a purely data-driven method. Our method was specifically designed to integrate blood gene expression and clinical biomarkers in a way that provides new mechanistic insights regarding the different asthma endotypes. For example, we describe metabolic syndrome-induced systemic inflammation as an associated factor in three of the four asthma endotypes. Context provided by the clinical biomarker data was essential in interpreting gene expression patterns and identifying putative endotypes, which emphasizes the importance of integrated approaches when studying complex disease etiologies. These synthesized patterns of gene expression and clinical markers from our research may lead to development of novel serum-based biomarker panels.
Article 2 Reads 5 Citations Sustainability, Health and Environmental Metrics: Impact on Ranking and Associations with Socioeconomic Measures for 50 ... Jane E. Gallagher, Elaine Cohen Hubal, Laura Jackson, Jeffer... Published: 22 February 2013
Sustainability, doi: 10.3390/su5020789
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Waste and materials management, land use planning, transportation and infrastructure including water and energy can have indirect or direct beneficial impacts on the environment and public health. The potential for impact, however, is rarely viewed in an integrated fashion. To facilitate such an integrated view in support of community-based policy decision making, we catalogued and evaluated associations between common, publically available, Environmental (e), Health (h), and Sustainability (s) metrics and sociodemographic measurements (n = 10) for 50 populous U.S. cities. E, H, S indices combined from two sources were derived from component (e) (h) (s) metrics for each city. A composite EHS Index was derived to reflect the integration across the E, H, and S indices. Rank order of high performing cities was highly dependent on the E, H and S indices considered. When viewed together with sociodemographic measurements, our analyses further the understanding of the interplay between these broad categories and reveal significant sociodemographic disparities (e.g., race, education, income) associated with low performing cities. Our analyses demonstrate how publically available environmental, health, sustainability and socioeconomic data sets can be used to better understand interconnections between these diverse domains for more holistic community assessments.
Article 4 Reads 5 Citations Mechanistic Indicators of Childhood Asthma (MICA) Study: piloting an integrative design for evaluating environmental hea... Jane Gallagher, Edward Hudgens, Ann Williams, Jefferson Inmo... Published: 19 May 2011
BMC Public Health, doi: 10.1186/1471-2458-11-344
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Asthma is a common complex disease responsible for considerable morbidity and mortality, particularly in urban minority populations. The Mechanistic Indicators of Childhood Asthma study was designed to pilot an integrative approach in children's health research. The study incorporates exposure metrics, internal dose measures, and clinical indicators to decipher the biological complexity inherent in diseases such as asthma and cardiovascular disease with etiology related to gene-environment interactions. 205 non-asthmatic and asthmatic children, (9-12 years of age) from Detroit, Michigan were recruited. The study includes environmental measures (indoor and outdoor air, vacuum dust), biomarkers of exposure (cotinine, metals, total and allergen specific Immunoglobulin E, polycyclic aromatic hydrocarbons, volatile organic carbon metabolites) and clinical indicators of health outcome (immunological, cardiovascular and respiratory). In addition, blood gene expression and candidate SNP analyses were conducted. Based on an integrative design, the MICA study provides an opportunity to evaluate complex relationships between environmental factors, physiological biomarkers, genetic susceptibility and health outcomes. PROJECT APPROVAL: IRB Number 05-EPA-2637: The human subjects' research protocol was reviewed by the Institutional Review Board (IRB) of the University of North Carolina; the IRB of Westat, Inc., the IRB of the Henry Ford Health System; and EPA's Human Subjects' Research Review Official.
Article 0 Reads 7 Citations Participant-based monitoring of indoor and outdoor nitrogen dioxide, volatile organic compounds, and polycyclic aromatic... Markey M. Johnson, Ron Williams, Zhihua Fan, Lin Lin, Edward... Published: 01 December 2010
Atmospheric Environment, doi: 10.1016/j.atmosenv.2010.08.027
DOI See at publisher website
BOOK-CHAPTER 0 Reads 3 Citations Biomarkers for Environmental Exposure Jane E. Gallagher, Elaine A. Cohen Hubal, Stephen W. Edwards Published: 03 November 2010
Biomarkers, doi: 10.1002/9780470918562.ch20
DOI See at publisher website