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Radim J. Sram   Dr.  Senior Scientist or Principal Investigator 
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Radim J. Sram published an article in December 2018.
Top co-authors See all
Peter Rudnai

153 shared publications

National Public Health Institute

Miroslav Machala

107 shared publications

Veterinary Research Institute

Jan Topinka

95 shared publications

Institute of Experimental Medicine AS CR; Prague Czech Republic

Zorana Jovanovic Andersen

77 shared publications

Center for Epidemiology and Screening, Department of Public Health, University of Copenhagen, Copenhagen, Denmark

Aleksandra Fucic

71 shared publications

Institute for Medical Research and Occupational Health, Zagreb, Croatia

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Distribution of Articles published per year 
(1996 - 2018)
Total number of journals
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17
 
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Article 0 Reads 0 Citations Greater susceptibility of girls to airborne Benzo[a]pyrene for obesity-associated childhood asthma Hyunok Choi, Miroslav Dostal, Anna Pastorkova, Pavel Rossner... Published: 01 December 2018
Environment International, doi: 10.1016/j.envint.2018.08.061
DOI See at publisher website ABS Show/hide abstract
Sexually dimorphic risk of obesity-associated asthma is posited to accelerate around puberty. Yet, the role of air pollution on the lean and obese asthmatic children has never been examined. To compare whether a unit exposure to airborne benzo[a]pyrene (B[a]P) is associated with altered risks of asthma across the overweight/obese (OV/OB) control, lean asthmatic, and OV/OB asthmatic children, respectively, compared to the lean controls, before and after adjusting for oxidant stress markers (i.e. 15‑F2t‑IsoP, 8‑oxo‑dG, and Carbonyl). Asthmatic and healthy control children, recruited from polluted urban and rural areas, were matched to ambient concentration of B[a]P. A unit increase in B[a]P and multinomial logistic regression on OV/OB control, lean asthmatic, and OV/OB asthma were compared across the sex- and age-groups. The median B[a]P was associated with a linear increase among the female children, according to OV/OB and asthma, respectively, and together, compared to the lean control girls (p = 0.001). While B[a]P was associated with positive relationship with 15‑F2t‑IsoP level among the OV/OB boys, the same exposure-outcome association was inverse among the OV/OB girls. One natural log-unit increase in ambient B[a]P was associated with 10.5-times greater odds (95% CI, 2.6–39.6; p = 0.001) the adolescent OV/OB boys, compared to the unit odds among the lean controls. In contrast, the adolescent OV/OB girls were associated with highest adjusted odds of the asthma (aOR = 15.4; 95% CI, 2.9–29.1; p < 0.001) compared to the lean control girls. An adjustment for 15‑F2t‑IsoP, and Carbonyls was associated with greater odds of asthma per unit exposure for the adolescent OV/OB girls (aOR = 16.2; 95% CI, 1.4–181.8; p = 0.024). B[a]P exposure was associated with a leap in the odds of asthma among the OV/OB adolescents, particularly the girls, after adjusting for 15‑F2t‑IsoP and Carbonyls.
Article 0 Reads 0 Citations Modeling Unobserved Heterogeneity in Susceptibility to Ambient Benzo[a]pyrene Concentration among Children with Allergic... Daniel Fernández, Radim J Srám, Miroslav Dostal, Anna Pastor... Published: 10 January 2018
International Journal of Environmental Research and Public Health, doi: 10.3390/ijerph15010106
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Current studies of gene × air pollution interaction typically seek to identify unknown heritability of common complex illnesses arising from variability in the host's susceptibility to environmental pollutants of interest. Accordingly, a single component generalized linear models are often used to model the risk posed by an environmental exposure variable of interest in relation to a priori determined DNA variants. However, reducing the phenotypic heterogeneity may further optimize such approach, primarily represented by the modeled DNA variants. Here, we reduce phenotypic heterogeneity of asthma severity, and also identify single nucleotide polymorphisms (SNP) associated with phenotype subgroups. Specifically, we first apply an unsupervised learning algorithm method and a non-parametric regression to find a biclustering structure of children according to their allergy and asthma severity. We then identify a set of SNPs most closely correlated with each sub-group. We subsequently fit a logistic regression model for each group against the healthy controls using benzo[a]pyrene (B[a]P) as a representative airborne carcinogen. Application of such approach in a case-control data set shows that SNP clustering may help to partly explain heterogeneity in children's asthma susceptibility in relation to ambient B[a]P concentration with greater efficiency.
Article 0 Reads 1 Citation Altered vulnerability to asthma at various levels of ambient Benzo[ a ]Pyrene by CTLA4, STAT4 and CYP2E1 polymorphisms Hyunok Choi, Nana Tabashidze, Pavel Rossner, Miroslav Dostal... Published: 01 December 2017
Environmental Pollution, doi: 10.1016/j.envpol.2017.07.057
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Article 0 Reads 0 Citations Measurement of 8-oxo-7,8-dihydro-2′-deoxyguanosine in urine by an improved ELISA Pavel Rossner, Hilmi Orhan, Gudrun Koppen, Kazuo Sakai, Regi... Published: 01 October 2017
Toxicology Letters, doi: 10.1016/j.toxlet.2017.07.128
DOI See at publisher website
Article 0 Reads 3 Citations Adaptation of the human population to the environment: Current knowledge, clues from Czech cytogenetic and “omics” biomo... Andrea Rossnerova, Michaela Pokorna, Vlasta Svecova, Radim J... Published: 01 July 2017
Mutation Research/Reviews in Mutation Research, doi: 10.1016/j.mrrev.2017.07.002
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Article 0 Reads 3 Citations Evaluation of 11 polycyclic aromatic hydrocarbon metabolites in urine of Czech mothers and newborns Katerina Urbancova, Darina Lankova, Pavel Rossner, Andrea Ro... Published: 01 January 2017
Science of The Total Environment, doi: 10.1016/j.scitotenv.2016.10.165
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