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Robert Morris   Dr.  University Lecturer 
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Robert Morris published an article in February 2019.
Top co-authors See all
Martin J Graves

241 shared publications

Radiology, Cambridge University Hospitals, Cambridge, UK

Glen McHale

190 shared publications

Smart Materials & Surfaces Laboratory, Faculty of Engineering & Environment , Northumbria University , Newcastle upon Tyne NE1 8ST , U.K.

Michael I. Newton

92 shared publications

School of Science and Technology; Nottingham Trent University; Nottingham UK

Neil J. Shirtcliffe

54 shared publications

Hochschule Rhein-Waal, Marie-Curie-Str. 1, Kleve D-47533, Germany

Frances Henson

41 shared publications

Division of Trauma and Orthopaedic Surgery University of Cambridge Addenbrooke's Hospital Hill's Road Cambridge

143
Publications
166
Reads
19
Downloads
114
Citations
Publication Record
Distribution of Articles published per year 
(1941 - 2019)
Total number of journals
published in
 
33
 
Publications See all
Article 0 Reads 0 Citations An evaluation of kefir grain size with magnetic resonance imaging to observe the fermentation of milk Abi Spicer, David J. Fairhurst, Michael I. Newton, Robert H.... Published: 22 February 2019
Magnetic Resonance in Chemistry, doi: 10.1002/mrc.4853
DOI See at publisher website
Article 0 Reads 0 Citations A preliminary study of milk powder hydration using TEDSpiL continuous wave NMR Steven T. Parslow, Najlaa K. Almazrouei, Michael I. Newton, ... Published: 21 February 2019
Magnetic Resonance in Chemistry, doi: 10.1002/mrc.4845
DOI See at publisher website
Article 0 Reads 0 Citations Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model Hareklea Markides, Karin J. Newell, Heike Rudorf, Lia Blokpo... Published: 11 January 2019
Stem Cell Research & Therapy, doi: 10.1186/s13287-018-1123-7
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Osteochondral injuries represent a significant clinical problem requiring novel cell-based therapies to restore function of the damaged joint with the use of mesenchymal stromal cells (MSCs) leading research efforts. Pre-clinical studies are fundamental in translating such therapies; however, technologies to minimally invasively assess in vivo cell fate are currently limited. We investigate the potential of a MRI- (magnetic resonance imaging) and superparamagnetic iron oxide nanoparticle (SPION)-based technique to monitor cellular bio-distribution in an ovine osteochondral model of acute and chronic injuries. MSCs were isolated, expanded and labelled with Nanomag, a 250-nm SPION, and using a novel cell-penetrating technique, glycosaminoglycan-binding enhanced transduction (GET). MRI visibility thresholds, cellular toxicity and differentiation potential post-labelling were assessed in vitro. A single osteochondral defect was created in the medial femoral condyle in the left knee joint of each sheep with the contralateral joint serving as the control. Cells, either GET-Nanomag labelled or unlabelled, were delivered 1 week or 4.5 weeks later. Sheep were sacrificed 7 days post implantation and immediately MR imaged using a 0.2-T MRI scanner and validated on a 3-T MRI scanner prior to histological evaluation. MRI data demonstrated a significant increase in MRI contrast as a result of GET-Nanomag labelling whilst cell viability, proliferation and differentiation capabilities were not affected. MRI results revealed evidence of implanted cells within the synovial joint of the injured leg of the chronic model only with no signs of cell localisation to the defect site in either model. This was validated histologically determining the location of implanted cells in the synovium. Evidence of engulfment of Nanomag-labelled cells by leukocytes is observed in the injured legs of the chronic model only. Finally, serum c-reactive protein (CRP) levels were measured by ELISA with no obvious increase in CRP levels observed as a result of P21-8R:Nanomag delivery. This study has the potential to be a powerful translational tool with great implications in the clinical translation of stem cell-based therapies. Further, we have demonstrated the ability to obtain information linked to key biological events occurring post implantation, essential in designing therapies and selecting pre-clinical models.
Article 0 Reads 3 Citations A Wearable Textile Thermograph Pasindu Lugoda, Theodore Hughes-Riley, Rob Morris, Tilak Dia... Published: 21 July 2018
Sensors, doi: 10.3390/s18072369
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
In medicine, temperature changes can indicate important underlying pathologies such as wound infection. While thermographs for the detection of wound infection exist, a textile substrate offers a preferable solution to the designs that exist in the literature, as a textile is very comfortable to wear. This work presents a fully textile, wearable, thermograph created using temperature-sensing yarns. As described in earlier work, temperature-sensing yarns are constructed by encapsulating an off-the-shelf thermistor into a polymer resin micro-pod and then embedding this within the fibres of a yarn. This process creates a temperature-sensing yarn that is conformal, drapeable, mechanically resilient, and washable. This work first explored a refined yarn design and characterised its accuracy to take absolute temperature measurements. The influence of contact errors with the refined yarns was explored seeing a 0.24 ± 0.03 measurement error when the yarn was held just 0.5 mm away from the surface being measured. Subsequently, yarns were used to create a thermograph. This work characterises the operation of the thermograph under a variety of simulated conditions to better understand the functionality of this type of textile temperature sensor. Ambient temperature, insulating material, humidity, moisture, bending, compression and stretch were all explored. This work is an expansion of an article published in The 4th International Conference on Sensor and Applications.
Article 0 Reads 2 Citations Developing Novel Temperature Sensing Garments for Health Monitoring Applications Pasindu Lugoda, Theodore Hughes-Riley, Carlos Oliveira, Rob ... Published: 10 July 2018
Fibers, doi: 10.3390/fib6030046
DOI See at publisher website ABS Show/hide abstract
Embedding temperature sensors within textiles provides an easy method for measuring skin temperature. Skin temperature measurements are an important parameter for a variety of health monitoring applications, where changes in temperature can indicate changes in health. This work uses a temperature sensing yarn, which was fully characterized in previous work, to create a series of temperature sensing garments: armbands, a glove, and a sock. The purpose of this work was to develop the design rules for creating temperature sensing garments and to understand the limitations of these devices. Detailed design considerations for all three devices are provided. Experiments were conducted to examine the effects of contact pressure on skin contact temperature measurements using textile-based temperature sensors. The temperature sensing sock was used for a short user trial where the foot skin temperature of five healthy volunteers was monitored under different conditions to identify the limitations of recording textile-based foot skin temperature measurements. The fit of the sock significantly affected the measurements. In some cases, wearing a shoe or walking also heavily influenced the temperature measurements. These variations show that textile-based foot skin temperature measurements may be problematic for applications where small temperature differences need to be measured.
Article 3 Reads 1 Citation Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Oste... Victoria Chapman, Hareklea Markides, Devi Rani Sagar, Luting... Published: 24 December 2017
Stem Cells International, doi: 10.1155/2017/2905104
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. The aims of this study were to determine the influence of a passage number on the effects of MSCs on pain behaviour and cartilage and bone features in a rodent model of OA. Rats underwent either medial meniscal transection (MNX) or sham surgery under anaesthesia. Rats received intra-articular injection of either 1.5 × 106 late passage MSCs labelled with 10 μg/ml SiMAG, 1.5 × 106 late passage mesenchymal stem cells, the steroid Kenalog (200 μg/20 μL), 1.5 × 106 early passage MSCs, or serum-free media (SFM). Sham-operated rats received intra-articular injection of SFM. Pain behaviour was quantified until day 42 postmodel induction. Magnetic resonance imaging (MRI) was used to localise the labelled cells within the knee joint. Late passage MSCs and Kenalog attenuated established pain behaviour in MNX rats, but did not alter MNX-induced joint pathology at the end of the study period. Early passage MSCs exacerbated MNX-induced pain behaviour for up to one week postinjection and did not alter joint pathology. Our data demonstrate for the first time the role of a passage number in influencing the therapeutic effects of MSCs in a model of OA pain.
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