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Prashanth Asuri   Dr.  Other 
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Prashanth Asuri published an article in October 2018.
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Top co-authors See all
Hohyun Lee

6 shared publications

Santa Clara University Department of Mechanical Engineering, Santa Clara, California, USA

Mayasari Lim

2 shared publications

Div. of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore;;; Correspondence concerning this article should be addressed to P. Asuri at

James Thomin

1 shared publications

Department of General Sciences, Northwest Florida State College, Niceville, FL 32578, USA

Josergio Zaragoza

1 shared publications

Department of Bioengineering, Santa Clara University, Santa Clara, CA 95053, USA

Marcus Kraus

1 shared publications

Department of Bioengineering, Santa Clara University, Santa Clara, CA 95053, USA

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Publication Record
Distribution of Articles published per year 
(2014 - 2018)
Total number of journals
published in
 
6
 
Publications See all
Article 0 Reads 0 Citations Exploring the Role of Nanoparticles in Enhancing Mechanical Properties of Hydrogel Nanocomposites Josergio Zaragoza, Scott Fukuoka, Marcus Kraus, James Thomin... Published: 29 October 2018
Nanomaterials, doi: 10.3390/nano8110882
DOI See at publisher website ABS Show/hide abstract
Over the past few decades, research studies have established that the mechanical properties of hydrogels can be largely impacted by the addition of nanoparticles. However, the exact mechanisms behind such enhancements are not yet fully understood. To further explore the role of nanoparticles on the enhanced mechanical properties of hydrogel nanocomposites, we used chemically crosslinked polyacrylamide hydrogels incorporating silica nanoparticles as the model system. Rheological measurements indicate that nanoparticle-mediated increases in hydrogel elastic modulus can exceed the maximum modulus that can be obtained through purely chemical crosslinking. Moreover, the data reveal that nanoparticle, monomer, and chemical crosslinker concentrations can all play an important role on the nanoparticle mediated-enhancements in mechanical properties. These results also demonstrate a strong role for pseudo crosslinking facilitated by polymer–particle interactions on the observed enhancements in elastic moduli. Taken together, our work delves into the role of nanoparticles on enhancing hydrogel properties, which is vital to the development of hydrogel nanocomposites with a wide range of specific mechanical properties.
Article 0 Reads 2 Citations Effect of crosslinker length on the elastic and compression modulus of poly(acrylamide) nanocomposite hydrogels J Zaragoza, A Chang, P Asuri Published: 01 January 2017
Journal of Physics: Conference Series, doi: 10.1088/1742-6596/790/1/012037
DOI See at publisher website
Article 3 Reads 5 Citations Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins Silviya Petrova Zustiak, Smritee Dadhwal, Carlos Medina, Son... Published: 03 September 2015
Biotechnology and Bioengineering, doi: 10.1002/bit.25709
DOI See at publisher website PubMed View at PubMed
Article 4 Reads 8 Citations Experimental Investigation of Mechanical and Thermal Properties of Silica Nanoparticle-Reinforced Poly(acrylamide) Nanoc... Josergio Zaragoza, Nasim BabHadiashar, Victor O’Brien, Andre... Published: 24 August 2015
PLOS ONE, doi: 10.1371/journal.pone.0136293
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Current studies investigating properties of nanoparticle-reinforced polymers have shown that nanocomposites often exhibit improved properties compared to neat polymers. However, over two decades of research, using both experimental studies and modeling analyses, has not fully elucidated the mechanistic underpinnings behind these enhancements. Moreover, few studies have focused on developing an understanding among two or more polymer properties affected by incorporation of nanomaterials. In our study, we investigated the elastic and thermal properties of poly(acrylamide) hydrogels containing silica nanoparticles. Both nanoparticle concentration and size affected hydrogel properties, with similar trends in enhancements observed for elastic modulus and thermal diffusivity. We also observed significantly lower swellability for hydrogel nanocomposites relative to neat hydrogels, consistent with previous work suggesting that nanoparticles can mediate pseudo crosslinking within polymer networks. Collectively, these results indicate the ability to develop next-generation composite materials with enhanced mechanical and thermal properties by increasing the average crosslinking density using nanoparticles.
Article 4 Reads 1 Citation Three-dimensional hydrogel encapsulated embryonic stem and carcinoma cells as culture platforms for cytotoxicity studies Sneha Oberai, Ailing Teo, Mayasari Lim, Kalpith Ramamoorthi,... Published: 01 August 2015
AIChE Journal, doi: 10.1002/aic.14957
DOI See at publisher website
Article 6 Reads 3 Citations A Novel 2.5D Culture Platform to Investigate the Role of Stiffness Gradients on Adhesion-Independent Cell Migration Mark-Phillip Pebworth, Sabrina A. Cismas, Prashanth Asuri Published: 13 October 2014
PLOS ONE, doi: 10.1371/journal.pone.0110453
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness. To better understand the effects of stiffness gradients on cell migration, we developed a 2.5D cell culture platform where cells are sandwiched between stiff tissue culture plastic and soft alginate hydrogel. Under these conditions, we observed migration of cells from the underlying stiff substrate into the alginate matrix. Observation of migration into alginate in the presence of integrin inhibition as well as qualitative microscopic analyses suggested an adhesion-independent cell migration mode. Observed migration was dependent on alginate matrix stiffness and the RhoA-ROCK-myosin-II pathway; inhibitors specifically targeting ROCK and myosin-II arrested cell migration. Collectively, these results demonstrate the utility of the 2.5D culture platform to advance our understanding of the effects of stiffness gradients and mechanotransductive signaling on adhesion-independent cell migration.
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