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Wendel Wohlleben      
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Wendel Wohlleben published an article in October 2018.
Top co-authors See all
Scott R Brown

434 shared publications

Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield UK

Claus-Michael Lehr

314 shared publications

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Department of Drug Delivery (DDEL), Campus E8.1, 66123, Saarbrücken, Germany

Helmut Cölfen

270 shared publications

Physical Chemistry; University of Konstanz; Universitätsstrasse 10, Box 714 78457 Konstanz Germany

Andrea Brunelli

243 shared publications

Department of Thoracic Surgery, Leeds Teaching Hospitals National Health System Trust, Leeds, United Kingdom

K Becker

240 shared publications

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany

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Distribution of Articles published per year 
(1970 - 2018)
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35
 
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Article 0 Reads 0 Citations Abiotic dissolution rates of 24 (nano)forms of 6 substances compared to macrophage-assisted dissolution and in vivo pulm... Johanna Koltermann-Jülly, Johannes G. Keller, Antje Venneman... Published: 01 October 2018
NanoImpact, doi: 10.1016/j.impact.2018.08.005
DOI See at publisher website ABS Show/hide abstract
Numerous recent reviews have highlighted the urgent need for methods to determine the biodissolution of nanomaterials in relevant lung fluids, and to validate the results against the bioprocessing in vivo. Moreover, it is largely unknown to what extent (nano)forms of a substance that differ in size, shape, or coating also differ in biodissolution. Here we apply a previously optimized abiotic flow-through method to 24 (nano)forms of 6 substances and compare the results with alveolar macrophage-assisted biodissolution of a subset of these nanomaterials in vitro and short-term inhalation results in vivo. As a main result we found that the results obtained with the flow-through method for the lung were consistent to the results of in vivo studies and were not improved by measuring alveolar macrophage-assisted biodissolution for up to 48 h. Based on selected benchmark materials we propose four groups of materials according to quantitative biodissolution rates (1 ng/cm2/h to 100 ng/cm2/h cutoffs) and qualitative transformation parameters, as detected by TEM analysis. These groups were also reflected by different lung clearance rates, as previously determined in short term inhalation studies. Biodissolution was similar within substance (nano)forms of Fe2O3, SiO2, CeO2, ZnO, though slightly varied upon surface area/coating. But the difference of biodissolution between the substances was in some cases >1000-fold. Among the Cu-containing materials, the behavior of the two CuPhthalocyanin nanoforms was similar with each other, but completely different than the dissolution and transformation of Cu salts. Different production routes and/or surface coatings significantly modulated biodissolution, whereas effects of shape or size were limited. In summary, we refined a protocol for the abiotic determination of biodissolution along with an integrated assessment of nanomaterial transformation. The protocol is suggested as tier 2 methodology for grouping and read-across purposes.
Article 6 Reads 2 Citations Identification of nanomaterials: A validation report of two laboratories using analytical ultracentrifugation with fixed... Dora Mehn, Iria Maria Rio-Echevarria, Douglas Gilliland, Mic... Published: 01 April 2018
NanoImpact, doi: 10.1016/j.impact.2017.12.005
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Article 4 Reads 1 Citation In Vitro and In Vivo Short-Term Pulmonary Toxicity of Differently Sized Colloidal Amorphous SiO2 Martin Wiemann, Ursula G. Sauer, Antje Vennemann, Sandra Bäc... Published: 13 March 2018
Nanomaterials, doi: 10.3390/nano8030160
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In vitro prediction of inflammatory lung effects of well-dispersed nanomaterials is challenging. Here, the in vitro effects of four colloidal amorphous SiO2 nanomaterials that differed only by their primary particle size (9, 15, 30, and 55 nm) were analyzed using the rat NR8383 alveolar macrophage (AM) assay. Data were compared to effects of single doses of 15 nm and 55 nm SiO2 intratracheally instilled in rat lungs. In vitro, all four elicited the release of concentration-dependent lactate dehydrogenase, β-glucuronidase, and tumor necrosis factor alpha, and the two smaller materials also released H2O2. All effects were size-dependent. Since the colloidal SiO2 remained well-dispersed in serum-free in vitro conditions, effective particle concentrations reaching the cells were estimated using different models. Evaluating the effective concentration–based in vitro effects using the Decision-making framework for the grouping and testing of nanomaterials, all four nanomaterials were assigned as “active.” This assignment and the size dependency of effects were consistent with the outcomes of intratracheal instillation studies and available short-term rat inhalation data for 15 nm SiO2. The study confirms the applicability of the NR8383 AM assay to assessing colloidal SiO2 but underlines the need to estimate and consider the effective concentration of such well-dispersed test materials.
Article 4 Reads 1 Citation Environmental Impacts by Fragments Released from Nanoenabled Products: A Multiassay, Multimaterial Exploration by the SU... Mónica J.B. Amorim, Sijie Lin, Karsten Schlich, José M. Nava... Published: 27 January 2018
Environmental Science & Technology, doi: 10.1021/acs.est.7b04122
DOI See at publisher website
Article 4 Reads 2 Citations Transformations of Nanoenabled Copper Formulations Govern Release, Antifungal Effectiveness, and Sustainability througho... Daniele Pantano, Nicole Neubauer, Jana Navrátilová, Lorette ... Published: 26 January 2018
Environmental Science & Technology, doi: 10.1021/acs.est.7b04130
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Article 1 Read 0 Citations Redefining environmental nanomaterial flows: consequences of the regulatory nanomaterial definition on the results of en... Henning Wigger, Wendel Wohlleben, Bernd Nowack Published: 01 January 2018
Environmental Science: Nano, doi: 10.1039/c8en00137e
DOI See at publisher website
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