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Wendel Wohlleben      
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Wendel Wohlleben published an article in January 2019.
Top co-authors See all
Wolfgang Peukert

426 shared publications

Institute of Particle Technology

Claus-Michael Lehr

320 shared publications

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI); Saarland University; Saarbrücken Germany

Willie J. G. M. Peijnenburg

257 shared publications

Institute of Environmental Sciences (CML), Leiden University, P.O. Box 9518, 2300 RA, Leiden, The Netherlands

Bernd Nowack

193 shared publications

Empa - Swiss Federal Laboratories for Material Science and Technology, Technology and Society Laboratory, St. Gallen, Switzerland

Helmut Cölfen

184 shared publications

Physical Chemistry; University of Konstanz; Universitätsstraße 10, Box 710 78467 Konstanz Germany

Publication Record
Distribution of Articles published per year 
(2002 - 2019)
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Article 0 Reads 0 Citations SUNDS probabilistic human health risk assessment methodology and its application to organic pigment used in the automoti... Lisa Pizzol, Danail Hristozov, Alex Zabeo, Gianpietro Basei,... Published: 01 January 2019
NanoImpact, doi: 10.1016/j.impact.2018.12.001
DOI See at publisher website
Article 0 Reads 0 Citations A technique-driven materials categorisation scheme to support regulatory identification of nanomaterials Claire Gaillard, Agnieszka Mech, Wendel Wohlleben, Frank Ger... Published: 01 January 2019
Nanoscale Advances, doi: 10.1039/c8na00175h
DOI See at publisher website ABS Show/hide abstract
Matching the performance profiles of particle sizing techniques with the material property profiles allows selecting the most appropriate technique and enables proper identification of nanomaterials.
Article 0 Reads 0 Citations Toxicity of copper oxide and basic copper carbonate nanoparticles after short-term oral exposure in rats Wim H. De Jong, Eveline De Rijk, Alessandro Bonetto, Wendel ... Published: 19 November 2018
Nanotoxicology, doi: 10.1080/17435390.2018.1530390
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Copper oxide (CuO) nanoparticles (NPs) and copper carbonate nanoparticles (Cu2CO3(OH)2 NPs have applications as antimicrobial agents and wood preservatives: an application that may lead to oral ingestion via hand to mouth transfer. Rats were exposed by oral gavage to CuO NPs and Cu2CO3(OH)2 NPs for five consecutive days with doses from 1 to 512 mg/kg and 4 to 128 mg/kg per day, respectively, and toxicity was evaluated at days 6 and 26. Both CuO NPs and Cu2CO3(OH)2 NPs induced changes in hematology parameters, as well as clinical chemistry markers (e.g. increased alanine aminotransferase, ALT) indicative of liver damage For CuO NPs histopathological alterations were observed in bone marrow, stomach and liver mainly consisting of an inflammatory response, ulceration, and degeneration. Cu2CO3(OH)2 NPs induced morphological alterations in the stomach, liver, intestines, spleen, thymus, kidneys, and bone marrow. In spleen and thymus lymphoid, depletion was noted that warrants further immunotoxicological evaluation. The NPs showed partial dissolution in artificial simulated stomach fluids, while in intestinal conditions, the primary particles simultaneously shrank and agglomerated into large structures. This means that both copper ions and the particulate nanoforms should be considered as potential causal agents for the observed toxicity. For risk assessment, the lowest bench mark dose (BMD) was similar for both NPs for the serum liver enzyme AST (an indication of liver toxicity), being 26.2 mg/kg for CuO NPs and 30.8 mg/kg for Cu2CO3(OH)2 NPs. This was surprising since the histopathology evidence demonstrates more severe organ damage for Cu2CO3(OH)2 NPs than for CuO NPs.
Article 0 Reads 0 Citations Abiotic dissolution rates of 24 (nano)forms of 6 substances compared to macrophage-assisted dissolution and in vivo pulm... Johanna Koltermann-Jülly, Johannes G. Keller, Antje Venneman... Published: 01 October 2018
NanoImpact, doi: 10.1016/j.impact.2018.08.005
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Numerous recent reviews have highlighted the urgent need for methods to determine the biodissolution of nanomaterials in relevant lung fluids, and to validate the results against the bioprocessing in vivo. Moreover, it is largely unknown to what extent (nano)forms of a substance that differ in size, shape, or coating also differ in biodissolution. Here we apply a previously optimized abiotic flow-through method to 24 (nano)forms of 6 substances and compare the results with alveolar macrophage-assisted biodissolution of a subset of these nanomaterials in vitro and short-term inhalation results in vivo. As a main result we found that the results obtained with the flow-through method for the lung were consistent to the results of in vivo studies and were not improved by measuring alveolar macrophage-assisted biodissolution for up to 48 h. Based on selected benchmark materials we propose four groups of materials according to quantitative biodissolution rates (1 ng/cm2/h to 100 ng/cm2/h cutoffs) and qualitative transformation parameters, as detected by TEM analysis. These groups were also reflected by different lung clearance rates, as previously determined in short term inhalation studies. Biodissolution was similar within substance (nano)forms of Fe2O3, SiO2, CeO2, ZnO, though slightly varied upon surface area/coating. But the difference of biodissolution between the substances was in some cases >1000-fold. Among the Cu-containing materials, the behavior of the two CuPhthalocyanin nanoforms was similar with each other, but completely different than the dissolution and transformation of Cu salts. Different production routes and/or surface coatings significantly modulated biodissolution, whereas effects of shape or size were limited. In summary, we refined a protocol for the abiotic determination of biodissolution along with an integrated assessment of nanomaterial transformation. The protocol is suggested as tier 2 methodology for grouping and read-across purposes.
Article 0 Reads 0 Citations Quantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives Danail Hristozov, Lisa Pizzol, Gianpietro Basei, Alex Zabeo,... Published: 12 June 2018
Nanotoxicology, doi: 10.1080/17435390.2018.1472314
DOI See at publisher website
Article 0 Reads 0 Citations Reduction of Acute Inhalation Toxicity Testing in Rats: The Contact Angle of Organic Pigments Predicts Their Suffocation... Thomas Hofmann, Lan Ma-Hock, Wera Teubner, Jasmin-Chasmina A... Published: 01 June 2018
Applied In Vitro Toxicology, doi: 10.1089/aivt.2018.0006
DOI See at publisher website