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Sang Hyun Sung   Professor  Senior Scientist or Principal Investigator 
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Sang Hyun Sung published an article in March 2019.
Top co-authors See all
L.A. Pieters

293 shared publications

Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, 2610 Wilrijk, Belgium

Jin Tae Hong

262 shared publications

College of Pharmacy and Medical Research Center, Chungbuk National University, Chungbuk 28160, Korea

Pieter C Dorrestein

258 shared publications


Tae-Jin Yang

162 shared publications

Department of Plant Science, Plant Genomics and Breeding Institute, Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea

Mi Kyeong Lee

151 shared publications

College of Pharmacy, Chungbuk National University, Cheongju, Korea

Publication Record
Distribution of Articles published per year 
(1995 - 2018)
Total number of journals
published in
Publications See all
Article 0 Reads 0 Citations Multiple Targets of 3-Dehydroxyceanothetric Acid 2-Methyl Ester to Protect Against Cisplatin-Induced Cytotoxicity in Kid... Dahae Lee, Ki Hyun Kim, Won Yung Lee, Chang-Eop Kim, Sang Hy... Published: 01 March 2019
Molecules, doi: 10.3390/molecules24050878
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Chronic exposure to cisplatin, a potent anticancer drug, causes irreversible kidney damage. In this study, we investigated the protective effect and mechanism of nine lupane- and ceanothane-type triterpenoids isolated from jujube (Ziziphus jujuba Mill., Rhamnaceae) on cisplatin-induced damage to kidney epithelial LLC-PK1 cells via mitogen-activated protein kinase (MAPK) and apoptosis pathways. Cisplatin-induced LLC-PK1 cell death was most significantly reduced following treatment with 3-dehydroxyceanothetric acid 2-methyl ester (3DC2ME). Additionally, apoptotic cell death was significantly reduced. Expression of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38 was markedly suppressed by 3DC2ME, indicating inhibition of the MAPK pathway. Treatment with 3DC2ME also significantly reduced expression of active caspase-8 and -3, Bcl-2-associated X protein (Bax), and B cell lymphoma 2 (Bcl-2), indicating the inhibition of apoptosis pathways in the kidneys. We also applied the network pharmacological analysis and identified multiple targets of 3DC2ME related to MAPK signaling pathway and apoptosis.
Article 0 Reads 0 Citations Expedient Synthesis of Alphitolic Acid and Its Naturally Occurring 2-O-Ester Derivatives Somin Park, JiHee Cho, Hongjun Jeon, Sang Hyun Sung, Seunghe... Published: 15 February 2019
Journal of Natural Products, doi: 10.1021/acs.jnatprod.8b00986
DOI See at publisher website
Article 0 Reads 1 Citation Lignan Dimers from Forsythia viridissima Roots and Their Antiviral Effects Jungmoo Huh, Jae Hyoung Song, Seong Ryeol Kim, Hyo Moon Cho,... Published: 24 January 2019
Journal of Natural Products, doi: 10.1021/acs.jnatprod.8b00590
DOI See at publisher website
Article 0 Reads 1 Citation Two complete chloroplast genome sequences and intra-species diversity for Rehmannia glutinosa (Orobanchaceae) Jae-Hyeon Jeon, Hyun-Seung Park, Jee Young Park, Tae Sun Kan... Published: 02 January 2019
Mitochondrial DNA Part B, doi: 10.1080/23802359.2018.1545529
DOI See at publisher website ABS Show/hide abstract
Rehmannia glutinosa is a plant used as traditional medicine for its various tonic effects in Korea and China. In this study, chloroplast genomes of two R. glutinosa were completed by de novo assembly using whole-genome Illumina sequence data. The length of chloroplast genomes of R. glutinosa collected from China and Korea was 153,680 bp and 153,499 bp, respectively. A total of 114 coding regions were predicted in both R. glutinosa including 80 protein-coding genes, 4 rRNA genes, and 30 tRNA genes. We identified abundant intra-species diversity of 87 InDels and 147 SNPs, among three R. glutinosa chloroplast genome sequences including one from GenBank. The phylogenetic analysis showed that these R. glutinosa were closely clustered with related Rehmannia species, separated from other Orobanchaceae and Scrophulariaceae species.
Article 0 Reads 1 Citation Screening of cytotoxic or cytostatic flavonoids with quantitative Fluorescent Ubiquitination-based Cell Cycle Indicator-... Young-Hyun Go, Hyo-Ju Lee, Hyeon-Joon Kong, Ho-Chang Jeong, ... Published: 19 December 2018
Royal Society Open Science, doi: 10.1098/rsos.181303
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
The Fluorescent Ubiquitination-based Cell Cycle Indicator (FUCCI) system can be used not only to study gene expression at a specific cell cycle stage, but also to monitor cell cycle transitions in real time. In this study, we used a single clone of FUCCI-expressing HeLa cells (FUCCI-HeLa cells) and monitored the cell cycle in individual live cells over time by determining the ratios between red fluorescence (RF) of RFP-Cdt1 and green fluorescence (GF) of GFP-Geminin. Cytotoxic and cytostatic compounds, the latter of which induced G2 or mitotic arrest, were identified based on periodic cycling of the RF/GF and GF/RF ratios in FUCCI-HeLa cells treated with anti-cancer drugs. With this cell cycle monitoring system, ten flavonoids were screened. Of these, apigenin and luteolin, which have a flavone backbone, were cytotoxic, whereas kaempferol, which has a flavonol backbone, was cytostatic and induced G2 arrest. In summary, we developed a system to quantitatively monitor the cell cycle in real time. This system can be used to identify novel compounds that modulate the cell cycle and to investigate structure–activity relationships.
Article 0 Reads 0 Citations A new phenolic compound from Phedimus middendorffianus with antiproliferative activity Jiho Lee, Sunmin Woo, Sang Hyun Sung, Heejung Yang Published: 23 November 2018
Natural Product Research, doi: 10.1080/14786419.2018.1527830
DOI See at publisher website