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Ya-Ju Chang published an article in May 2018.
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254 shared publications
186 shared publications
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health; Maryland
153 shared publications
James Chih-Hsin Yang
141 shared publications
134 shared publications
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(1998 - 2018)
(1998 - 2018)
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Article 0 Reads 0 Citations The Sustainable Child Development Index (SCDI) for Countries Published: 14 May 2018
Sustainability, doi: 10.3390/su10051563
Despite the relevance of children in inheriting and shaping society, an index assessing sustainable development with a focus on children is missing. To tackle this gap, this study established the Sustainable Child Development Index (SCDI) by considering child development topics in the context of inter-generational equity and applying indicators with available statistical data on country level. The SCDI at present addresses health, education, safety, economic status and environmental aspects described by 25 indicators. By taking reference points derived from the targets of the Sustainable Development Goals (SDGs), the SCDI scores for the year 2015 were calculated for 138 countries and then classified into four sustainable child development levels (very high, high, medium and low). The results showed great regional inequality on the status of sustainable child development. European countries generally have better status of sustainable child development. By contrast, 90% of African and 76% of Asian countries were classified as countries with medium and low levels. Moreover, the comparison of the SCDI, the Human Development Index (HDI) and the Child Development Index (CDI) based on correlation analysis and 10-year (2006–2015) country rankings demonstrated that the SCDI can complement existing development indices to provide a more comprehensive evaluation of sustainable development.
Article 0 Reads 0 Citations THE APPLICATIONS OF SMART MOBILE DEVICE FOR DETECTING BALANCE DYSFUNCTION IN INDIVIDUALS WITH DOWN SYNDROME Published: 01 February 2018
Biomedical Engineering: Applications, Basis and Communications, doi: 10.4015/s1016237218500072
Falls are a major health concern leading cause of fatal and non-fatal injuries for neurological disorders. Balance dysfunction is one of the common factors to determine fall risk in neurological patients. Preventative measures may help to reduce the incidence and severity of falls for detecting balance function and fall risk factors. However, the objective measures for balance require expensive equipment with the assessment of clinical expertise. A main gap remains in the evaluation method to objectively characterize the balance functions in individuals with high risk of falling. With the development of wearable and mobile devices, recent advances in smart mobile devices may provide a potential opportunity to manage the gap in the detailed quantification of balance impairments. The purpose of this study is to identify whether the biomechanical data measured by the mobile device is reliable to characterize the posture stability in various balance test conditions. A total of 39 children with Down syndrome completed four balance-testing tasks under altered base of support and vision. Simultaneous biomechanical measurements were gathered from the iPod and force plate analysis system during functional balance testing. The force plate and mobile system provided similar patterns of stability across groups. Correlation (r2) between two systems for path length, 95% ellipse area, peak-to-peak, standard deviation and mean ranged from 0.60 to 0.99. We expect that the smart mobile device can provide reliable and accurate information to quantify the postural stability in individuals with elderly people or neurological disorders. The objectivity, portability and easy use of such mobile device make it ideal to apply in clinical environments for detecting balance functions and reducing the risk of falls in Down syndrome or other neurological patients.
Article 0 Reads 1 Citation Mechanogenetics for the remote and noninvasive control of cancer immunotherapy Published: 17 January 2018
Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.1714900115
While cell-based immunotherapy, especially chimeric antigen receptor (CAR)-expressing T cells, is becoming a paradigm-shifting therapeutic approach for cancer treatment, there is a lack of general methods to remotely and noninvasively regulate genetics in live mammalian cells and animals for cancer immunotherapy within confined local tissue space. To address this limitation, we have identified a mechanically sensitive Piezo1 ion channel (mechanosensor) that is activatable by ultrasound stimulation and integrated it with engineered genetic circuits (genetic transducer) in live HEK293T cells to convert the ultrasound-activated Piezo1 into transcriptional activities. We have further engineered the Jurkat T-cell line and primary T cells (peripheral blood mononuclear cells) to remotely sense the ultrasound wave and transduce it into transcriptional activation for the CAR expression to recognize and eradicate target tumor cells. This approach is modular and can be extended for remote-controlled activation of different cell types with high spatiotemporal precision for therapeutic applications.
Article 0 Reads 0 Citations Effect of EMG-triggered neuromuscular electrical stimulation with bilateral arm training on hemiplegic shoulder pain and... Published: 28 November 2017
Journal of NeuroEngineering and Rehabilitation, doi: 10.1186/s12984-017-0332-0
Background Hemiplegic shoulder pain is a frequent complication after stroke, leading to limited use of the affected arm. Neuromuscular electrical stimulation (NMES) and transcutaneous electrical nerve stimulation (TENS) are two widely used interventions to reduce pain, but the comparative efficacy of these two modalities remains uncertain. The purpose of this research was to compare the immediate and retained effects of EMG-triggered NMES and TENS, both in combination with bilateral arm training, on hemiplegic shoulder pain and arm function of stroke patients. Methods A single-blind, randomized controlled trial was conducted at two medical centers. Thirty-eight patients (25 males and 13 females, 60.75 ± 10.84 years old, post stroke duration 32.68 ± 53.07 months) who had experienced a stroke more than 3 months ago at the time of recruitment and hemiplegic shoulder pain were randomized to EMG-triggered NMES or TENS. Both groups received electrical stimulation followed by bilateral arm training 3 times a week for 4 weeks. The primary outcome measures included a vertical Numerical Rating Scale supplemented with a Faces Rating Scale, and the short form of the Brief Pain Inventory. The secondary outcome measures were the upper-limb subscale of the Fugl-Meyer Assessment, and pain-free passive shoulder range of motion. All outcomes were measured pretreatment, post-treatment, and at 1-month after post-treatment. Two-way mixed repeated measures ANOVAs were used to examine treatment effects. Results Compared to TENS with bilateral arm training, the EMG-triggered NMES with bilateral arm training was associated with lower pain intensity during active and passive shoulder movement (P =0.007, P =0.008), lower worst pain intensity (P = 0.003), and greater pain-free passive shoulder abduction (P =0.001) and internal rotation (P =0.004) at follow-up. Both groups improved in pain at rest (P =0.02), pain interference with daily activities, the Fugl-Meyer Assessment, and pain-free passive shoulder flexion and external rotation post-treatment (P < 0.001) and maintained the improvement at follow-up (P < 0.001), except for resting pain (P =0.08). Conclusions EMG-triggered NMES with bilateral arm training exhibited greater immediate and retained effects than TENS with bilateral arm training with respect to pain and shoulder impairment for chronic and subacute stroke patients with hemiplegic shoulder pain. Trial registration NCT01913509.
Article 0 Reads 3 Citations Environmental energy efficiency of single wire and tandem gas metal arc welding Published: 12 April 2017
Welding in the World, doi: 10.1007/s40194-017-0460-y
Article 0 Reads 1 Citation Screening Indicators for the Sustainable Child Development Index (SCDI) Published: 29 March 2017
Sustainability, doi: 10.3390/su9040518
Since children are the key stakeholders supporting and being affected by sustainable development, the framework for the Sustainable Child Development Index (SCDI) was proposed. It addresses social, economic and environmental dimensions of sustainable development by considering seven relevant themes of child development, i.e., health, education, safety, economic status, relationship, environmental aspects and participation. However, an indicator set for initiating the SCDI is still missing. In this study, indicators for the themes, subthemes and criteria of SCDI are identified from literature and then analyzed regarding data availability. Sixty-six indicators with statistical data covering at least 100 countries are selected as the indicator set for the SCDI. The results indicate that data availability is best for indicators describing the themes of health and education, and worst for indicators addressing the themes of relationship and participation. Furthermore, 21 subthemes and 50 criteria described by indicators with limited data availability are identified for future indicator and data development. By providing an initial indicator set and screening the indicators with regard to data availability, the practicality of the SCDI framework is expected. Furthermore, the indicator set can serve as a potential indicator pool for other child and sustainable development related studies.