Please login first
Valentina Castellani   Dr.  Research or Laboratory Scientist 
Timeline See timeline
Valentina Castellani published an article in May 2018.
Top co-authors See all
Romano Silvestri

150 shared publications

Department of Drug Chemistry and Technologies; Sapienza University of Rome; Rome Italy

Roberto Carnevale

120 shared publications

Lorenzo Loffredo

101 shared publications

Department of Internal Medicine and Medical Specialties; Sapienza University of Rome; Rome Italy

Elena Collina

60 shared publications

Francesco Violi

36 shared publications

Department of Internal Medicine and Medical Specialties; Sapienza University of Rome; Rome Italy

Publication Record
Distribution of Articles published per year 
(2012 - 2018)
Total number of journals
published in
Publications See all
Article 0 Reads 0 Citations Oleuropein, a component of extra virgin olive oil, lowers postprandial glycaemia in healthy subjects Roberto Carnevale, Romano Silvestri, Lorenzo Loffredo, Marta... Published: 02 May 2018
British Journal of Clinical Pharmacology, doi: 10.1111/bcp.13589
DOI See at publisher website
ABS Show/hide abstract
Aims Extra virgin olive oil (EVOO) lowers post‐prandial glycaemia. We investigated if oleuropein, a component of EVOO, exerts a similar effect on post‐prandial glycaemia and the underlying mechanism. Methods Twenty healthy subjects were randomly allocated in a cross‐over design to 20 mg oleuropein or placebo immediately before lunch. Post‐prandial glycaemia along with blood insulin, dipeptidyl‐peptidase‐4 (DPP‐4) and glucagon‐like peptide‐1 (GLP‐1) and oxidative stress, which included Nox2 activity(sNox2‐dp), 8‐iso‐PGF2α and platelet p47phox phosphorylation, were analysed before and two hours after meal. Results After two hours, subjects who assumed oleuropein had significantly lower blood glucose, DPP‐4 activity and higher insulin and GLP‐1 compared to placebo. Furthermore, sNox2‐dp, 8‐iso‐PGF2α and platelet p47phox phosphorylation were significantly lower in oleuropein‐ compared to placebo‐treated subjects. DDP4 significantly correlated with sNox2‐dp, (Spearman's rho (Rs)=0.615; p<0.001), p47phox phosphorylation (Rs=0.435; p<0.05) and 8‐iso‐PGF2α (Rs=0.33; p<0.05). In vitro study demonstrated that hydroxytyrosol (HT), a metabolite of oleuropein, significantly reduced p47phox phosphorylation and isoprostane formation. Conclusions These findings indicate that oleuropein improves post‐prandial glycaemic profile via hampering Nox2‐derived oxidative stress.
Article 0 Reads 0 Citations Glucocorticoids impair platelet thromboxane biosynthesis in community-acquired pneumonia Roberto Cangemi, Roberto Carnevale, Cristina Nocella, Camill... Published: 01 May 2018
Pharmacological Research, doi: 10.1016/j.phrs.2018.03.014
DOI See at publisher website
Article 0 Reads 8 Citations Environmental impacts of food consumption in Europe Giuseppe Tassielli, Pietro Alexander Renzulli, Bruno Notarni... Published: 01 January 2017
Journal of Cleaner Production, doi: 10.1016/j.jclepro.2016.06.080
DOI See at publisher website
ABS Show/hide abstract
Highlights•Identification of the 17 most representative products (Basket of products) of European food consumption.•Environmental impacts of the basket of products are assessed through a Life Cycle Assessment from cradel to grave.•Meat and dairy products present the highest contribution of the overall impact of the basket.•Agriculture is the most impacting life cycle stage for almost all the products. AbstractFood consumption is amongst the main drivers of environmental impacts. On one hand, there is the need to fulfil a fundamental human need for nutrition, and on the other hand this poses critical threats to the environment. In order to assess the environmental impact of food consumption, a lifecycle assessment (LCA)-based approach has been applied to a basket of products, selected as being representative of EU consumption. A basket of food products was identified as representative of the average food and beverage consumption in Europe, reflecting the relative importance of the products in terms of mass and economic value. The products in the basket are: pork, beef, poultry, milk, cheese, butter, bread, sugar, sunflower oil, olive oil, potatoes, oranges, apples, mineral water, roasted coffee, beer and pre-prepared meals. For each product in the basket, a highly disaggregated inventory model was developed based on a modular approach, and built using statistical data. The environmental impact of the average food consumption of European citizens was assessed using the International Reference Life Cycle Data System (ILCD) methodology. The overall results indicate that, for most of the impact categories, the consumed foods with the highest environmental burden are meat products (beef, pork and poultry) and dairy products (cheese, milk and butter). The agricultural phase is the lifecycle stage that has the highest impact of all the foods in the basket, due to the contribution of agronomic and zootechnical activities. Food processing and logistics are the next most important phases in terms of environmental impacts, due to their energy intensity and the related emissions to the atmosphere that occur through the production of heat, steam and electricity and during transport. Regarding the end-of-life phase, human excretion and wastewater treatments pose environmental burdens related to eutrophying substances whose environmental impacts are greater than those of the agriculture, transports and processing phases. Moreover, food losses which occur throughout the whole lifecycle, in terms of agricultural/industrial and domestic food waste, have also to be taken into consideration, since they can amount to up to 60% of the initial weight of the food products. The results of the study go beyond the mere assessment of the potential impacts associated with food consumption, as the overall approach may serve as a baseline for testing eco-innovation scenarios for impact reduction as well as for setting targets.
Article 0 Reads 4 Citations Hotspots analysis and critical interpretation of food life cycle assessment studies for selecting eco-innovation options... Serenella Sala, Valentina Castellani, Lorenzo Benini Published: 01 January 2017
Journal of Cleaner Production, doi: 10.1016/j.jclepro.2016.05.078
DOI See at publisher website
ABS Show/hide abstract
Highlights•Sensitivity analysis of environmental impacts is applied to food products consumed in Europe.•A systematic framework for the interpretation of life cycle assessment results is provided.•Sensitivity analyses show diverging results about the relevance of impact categories.•Consumption of meat and dairy products shows the highest environmental impact.•Relevance of impact categories is more influenced by normalization than by weighting. AbstractFood production and consumption have been identified among the human interventions generating huge pressures and impacts on the environment. Policies aiming at sustainable production and consumption need to identify hotspots in order to decide where and how to act to steer eco-innovation and to reduce impacts. This could be achieved by applying a life cycle perspective and having a thorough and systematic interpretation of the results of the assessment within and beyond LCA results. The present study aims at presenting a life cycle based method for hotspots analysis focusing on the life cycle impact assessment steps (characterisation, normalisation and weighting). These steps, which support a correct interpretation of the results, are often performed superficially and not in a systematic way. Hence, in this study, we propose a procedure for supporting the interpretation of LCA results, complementing the assessment with an analysis of hotspots of impact beyond those identified by LCA, to avoid excluding potential hotspots only because they are not fully captured by the current LCIA methods. A case study on hotspot analysis and interpretation of results is presented, building on the results of a previous study, which assessed the impact of EU food consumption based on the LCA of 17 representative food products. The present study includes: i) a hotspots analysis on characterized and normalised results, ii) the check of un-characterized elementary flows, iii) a sensitivity analysis of the results applying several LCIA methods, normalisation references and weighting factors. For all the analyses, product group contribution and impact category relevance are assessed. The results of the hotspot analyses are generally convergent in identifying the most impacting product groups (meat and dairy), whereas they are sometimes diverging in identifying the most relevant impact categories. In this case study, the identification of the most relevant impact categories is mainly influenced by the selection of the set of normalization references compared to that of the weighting sets.
Article 0 Reads 3 Citations Assessing eco-innovations in green chemistry: LCA of a cosmetic product with a bio-based ingredient Michela Secchi, Valentina Castellani, Elena Collina, Nadia M... Published: 01 August 2016
Journal of Cleaner Production, doi: 10.1016/j.jclepro.2016.04.073
DOI See at publisher website
ABS Show/hide abstract
Highlights•A Life Cycle Perspective is needed to assess sustainability of bio-based materials.•Green chemistry strategies should be assessed in order to highlight potential impacts.•Ingredients’ choice may affect environmental performance more than cream production.•Ingredients dosage and formulation can help to improve sustainability of cosmetics.•Current limits in LCIA methods and LCI data can affect the reliability of results. AbstractEnhancing and promoting eco-innovation solutions in cosmetic industry requires robust methods for assessing the environmental impacts and reducing burden shifting amongst life cycle stages and typology of impacts. This study aims at comparing the environmental profile of eco-innovation options for a cosmetic product by means of Life Cycle Assessment (LCA) methodology. We present a case study in which synthetic ingredients are replaced by others derived from natural compounds, following green chemistry principles. A C16-18 triglycerides mixture (INCI name “palmitic/stearic triglycerides”) derived from olive oil industry by-products is used both as single ingredient (Innovation I) and as part of a preformulated one (Innovation II), replacing the starting formulation (Benchmark) caprylic/capric triglyceride. Options are compared through LCA applying ILCD impact assessment focusing the analysis to water and energy consumption, sources of raw materials and previous manufacturing stages thereof. In order to test the robustness of the results, we performed a set of sensitivity analyses: i) changing assumptions about transports and irrigation of olive trees; ii) comparing results of the application of two LCIA methods (CML and IMPACT 2002). The results show that the impacts derived from the selection of ingredients are more significant than those due to water and energy consumption. Applying different methods, results show significant differences, especially in toxicity-related impact categories. Overall, an alleged “eco-friendly” ingredient (such as a natural by-product derived one) could result in a less preferable environmental profile if assessed in a life cycle perspective. This supports the need of adopting life cycle based methods to ensure that green chemistry options respond to the need of reducing environmental in all life cycle stages.
Article 0 Reads 4 Citations A distance-to-target weighting method for Europe 2020 Valentina Castellani, Lorenzo Benini, Serenella Sala, Rana P... Published: 22 March 2016
The International Journal of Life Cycle Assessment, doi: 10.1007/s11367-016-1079-8
DOI See at publisher website