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Maria Mernea   Dr.  Post Doctoral Researcher 
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Maria Mernea published an article in March 2018.
Top co-authors See all
Mihai V. Putz

97 shared publications

Laboratory of Structural and Computational Physical-Chemistry for Nanosciences and QSAR, Biology-Chemistry Department, West University of Timisoara, Timisoara, RO, Romania

Cătălin Buiu

36 shared publications

Department of Automatic Control and Systems Engineering, Faculty of Automatic Control and Computers, Politehnica University of Bucharest, Bucharest 060042, Romania

Adina-Luminita Milac

28 shared publications

Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania

T. Dascalu

21 shared publications

National Institute for Laser, Plasma and Radiation Physics, Laboratory of Solid-State Quantum Electronics, Bucharest 077125, Romania

Mihai&nbspv.&nbspputz

12 shared publications

Laboratory of Structural and Computational Physical-Chemistry for Nanosciences and QSAR, Biology-Chemistry Department, West University of Timisoara, Pestalozzi Street No. 44, Timisoara, RO-300115, Romania

21
Publications
31
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0
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30
Citations
Publication Record
Distribution of Articles published per year 
(2009 - 2018)
Total number of journals
published in
 
18
 
Publications See all
Article 4 Reads 0 Citations Dynamic analysis of the interactions between Si/SiO2 quantum dots and biomolecules for improving applications based on n... Miruna Silvia Stan, Ludmila Otilia Cinteză, Livia Petrescu, ... Published: 27 March 2018
Scientific Reports, doi: 10.1038/s41598-018-23621-x
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Due to their outstanding properties, quantum dots (QDs) received a growing interest in the biomedical field, but it is of major importance to investigate and to understand their interaction with the biomolecules. We examined the stability of silicon QDs and the time evolution of QDs – protein corona formation in various biological media (bovine serum albumin, cell culture medium without or supplemented with 10% fetal bovine serum-FBS). Changes in the secondary structure of BSA were also investigated over time. Hydrodynamic size and zeta potential measurements showed an evolution in time indicating the nanoparticle-protein interaction. The protein corona formation was also dependent on time, albumin adsorption reaching the peak level after 1 hour. The silicon QDs adsorbed an important amount of FBS proteins from the first 5 minutes of incubation that was maintained for the next 8 hours, and diminished afterwards. Under protein-free conditions the QDs induced cell membrane damage in a time-dependent manner, however the presence of serum proteins attenuated their hemolytic activity and maintained the integrity of phosphatidylcholine layer. This study provides useful insights regarding the dynamics of BSA adsorption and interaction of silicon QDs with proteins and lipids, in order to understand the role of QDs biocorona.
BOOK-CHAPTER 0 Reads 0 Citations Up-Converting Nanoparticles Livia Petrescu, Speranta Avram, Maria Mernea, Dan Florin Mih... Published: 01 January 2018
Biomedical Engineering, doi: 10.4018/978-1-5225-3158-6.ch011
DOI See at publisher website
BOOK-CHAPTER 2 Reads 0 Citations Up-Converting Nanoparticles Livia Petrescu, Speranta Avram, Maria Mernea, Dan Florin Mih... Published: 01 January 2017
Advances in Chemical and Materials Engineering, doi: 10.4018/978-1-5225-0492-4.ch012
DOI See at publisher website
Article 0 Reads 4 Citations Chemical Structure-Biological Activity Models for Pharmacophores’ 3D-Interactions Mihai V. Putz, Corina Duda-Seiman, Daniel Duda-Seiman, Ana-M... Published: 08 July 2016
International Journal of Molecular Sciences, doi: 10.3390/ijms17071087
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Within medicinal chemistry nowadays, the so-called pharmaco-dynamics seeks for qualitative (for understanding) and quantitative (for predicting) mechanisms/models by which given chemical structure or series of congeners actively act on biological sites either by focused interaction/therapy or by diffuse/hazardous influence. To this aim, the present review exposes three of the fertile directions in approaching the biological activity by chemical structural causes: the special computing trace of the algebraic structure-activity relationship (SPECTRAL-SAR) offering the full analytical counterpart for multi-variate computational regression, the minimal topological difference (MTD) as the revived precursor for comparative molecular field analyses (CoMFA) and comparative molecular similarity indices analysis (CoMSIA); all of these methods and algorithms were presented, discussed and exemplified on relevant chemical medicinal systems as proton pump inhibitors belonging to the 4-indolyl,2-guanidinothiazole class of derivatives blocking the acid secretion from parietal cells in the stomach, the 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio)thymine congeners’ (HEPT ligands) antiviral activity against Human Immunodeficiency Virus of first type (HIV-1) and new pharmacophores in treating severe genetic disorders (like depression and psychosis), respectively, all involving 3D pharmacophore interactions.
Article 7 Reads 0 Citations Evaluation of the Therapeutic Properties of Mastoparan- and Sifuvirtide- Derivative Antimicrobial Peptides Using Chemica... Speranta Avram, Maria Mernea, Florin Borcan, Dan Mihailescu Published: 01 January 2016
Current Drug Delivery,
PubMed View at PubMed
Article 0 Reads 0 Citations Effects of Cd2+ on the epithelial Na+ channel (ENaC) investigated by experimental and modeling studies. Maria Mernea, Roxana Ulăreanu, Octavian Călborean, Sergiu Ch... Published: 01 January 2016
General Physiology and Biophysics, doi: 10.4149/gpb_2015054
DOI See at publisher website PubMed View at PubMed
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