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Pieter C Dorrestein  - - - 
Top co-authors See all
O. Guntinas-Lichius

798 shared publications

Department of Otolaryngology, Head and Neck Surgery; Jena University Hospital; Jena Germany

Rob Knight

740 shared publications

UCSD School of Medicine

Victor Nizet

470 shared publications

University of California San Diego School of Medicine

Alexander Laskin

441 shared publications

Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA

William H. Gerwick

288 shared publications

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093, United States

238
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Publication Record
Distribution of Articles published per year 
(2006 - 2019)
Total number of journals
published in
 
33
 
Publications See all
PREPRINT-CONTENT 0 Reads 0 Citations MASST: A Web-based Basic Mass Spectrometry Search Tool for Molecules to Search Public Data Mingxun Wang, Alan K. Jarmusch, Fernando Vargas, Alexander A... Published: 28 March 2019
bioRxiv, doi: 10.1101/591016
DOI See at publisher website ABS Show/hide abstract
CorrespondenceWe introduce a web-enabled small-molecule mass spectrometry (MS) search engine. To date, no tool can query all the public small-molecule tandem MS data in metabolomics repositories, greatly limiting the utility of these resources in clinical, environmental and natural product applications. Therefore, we introduce a Mass Spectrometry Search Tool (MASST) (https://proteosafe-extensions.ucsd.edu/masst/), that enables the discovery of molecular relationships among accessible public metabolomics and natural product tandem mass spectrometry data (MS/MS).
Article 0 Reads 0 Citations SIRIUS 4: a rapid tool for turning tandem mass spectra into metabolite structure information Kai Dührkop, Markus Fleischauer, Marcus Ludwig, Alexander A.... Published: 18 March 2019
Nature Methods, doi: 10.1038/s41592-019-0344-8
DOI See at publisher website
Article 0 Reads 0 Citations Viscosin-like lipopeptides from frog skin bacteria inhibit Aspergillus fumigatus and Batrachochytrium dendrobatidis dete... Christian Martin H., Roberto Ibáñez, Louis-Félix Nothias, Cr... Published: 28 February 2019
Scientific Reports, doi: 10.1038/s41598-019-39583-7
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Amphibian populations worldwide have declined and in some cases become extinct due to chytridiomycosis, a pandemic disease caused by the fungus Batrachochytrium dendrobatidis; however, some species have survived these fungal epidemics. Previous studies have suggested that the resistance of these species is due to the presence of cutaneous bacteria producing antifungal metabolites. As our understanding of these metabolites is still limited, we assessed the potential of such compounds against human-relevant fungi such as Aspergillus. In this work we isolated 201 bacterial strains from fifteen samples belonging to seven frog species collected in the highlands of Panama and tested them against Aspergillus fumigatus. Among the 29 bacterial isolates that exhibited antifungal activity, Pseudomonas cichorii showed the greatest inhibition. To visualize the distribution of compounds and identify them in the inhibition zone produced by P. cichorii, we employed MALDI imaging mass spectrometry (MALDI IMS) and MS/MS molecular networking. We identified viscosin and massetolides A, F, G and H in the inhibition zone. Furthermore, viscosin was isolated and evaluated in vitro against A. fumigatus and B. dendrobatidis showing MIC values of 62.50 µg/mL and 31.25 µg/mL, respectively. This is the first report of cyclic depsipeptides with antifungal activity isolated from frog cutaneous bacteria.
Article 0 Reads 1 Citation Comprehensive mass spectrometry-guided phenotyping of plant specialized metabolites reveals metabolic diversity in the c... Kyo Bin Kang, Madeleine Ernst, Justin J. J Van Der Hooft, Ri... Published: 20 February 2019
The Plant Journal, doi: 10.1111/tpj.14292
DOI See at publisher website PubMed View at PubMed
Article 0 Reads 0 Citations Mass Spectrometry Uncovers the Role of Surfactin as an Interspecies Recruitment Factor Tal Luzzatto-Knaan, Alexey V. Melnik, Pieter C. Dorrestein Published: 14 February 2019
ACS Chemical Biology, doi: 10.1021/acschembio.8b01120
DOI See at publisher website
Article 0 Reads 0 Citations Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome Robert A. Quinn, Sandeep Adem, Robert H. Mills, William Coms... Published: 13 February 2019
Microbiome, doi: 10.1186/s40168-019-0636-3
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Studies of the cystic fibrosis (CF) lung microbiome have consistently shown that lung function decline is associated with decreased microbial diversity due to the dominance of opportunistic pathogens. However, how this phenomenon is reflected in the metabolites and chemical environment of lung secretions remains poorly understood. Here we investigated the microbial and molecular composition of CF sputum samples using 16S rRNA gene amplicon sequencing and untargeted tandem mass spectrometry to determine their interrelationships and associations with clinical measures of disease severity. The CF metabolome was found to exist in two states: one from patients with more severe disease that had higher molecular diversity and more Pseudomonas aeruginosa and the other from patients with better lung function having lower metabolite diversity and fewer pathogenic bacteria. The two molecular states were differentiated by the abundance and diversity of peptides and amino acids. Patients with severe disease and more pathogenic bacteria had higher levels of peptides. Analysis of the carboxyl terminal residues of these peptides indicated that neutrophil elastase and cathepsin G were responsible for their generation, and accordingly, these patients had higher levels of proteolytic activity from these enzymes in their sputum. The CF pathogen Pseudomonas aeruginosa was correlated with the abundance of amino acids and is known to primarily feed on them in the lung. In cases of severe CF lung disease, proteolysis by host enzymes creates an amino acid-rich environment that P. aeruginosa comes to dominate, which may contribute to the pathogen’s persistence by providing its preferred carbon source. The online version of this article (10.1186/s40168-019-0636-3) contains supplementary material, which is available to authorized users.
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