Please login first
Gitta Schlosser  - - - 
Top co-authors See all
Ferenc Hudecz

8 shared publications

Institute of Chemistry, Eötvös Loránd University (ELTE), Budapest, H-1117 Budapest, Hungary;(P.B.);(I.K.);(T.C.);(C.L.S.);(G.S.);(F.H.)

Gábor Mező

4 shared publications

MTA-ELTE Research Group of Peptide Chemistry, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary;(R.S.O.);(S.B.);(G.M.)

Szilvia Bősze

4 shared publications

MTA-ELTE Research Group of Peptide Chemistry, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary;(R.S.O.);(S.B.);(G.M.)

Angéla Takács

1 shared publications

Department of Genetics, Cell and Immunobiology, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary;(A.T.);(E.L.);(O.L.);(L.K.)

Antal Csámpai

1 shared publications

Institute of Chemistry, Eötvös Loránd University (ELTE), Budapest, H-1117 Budapest, Hungary;(P.B.);(I.K.);(T.C.);(C.L.S.);(G.S.);(F.H.)

3
Publications
0
Reads
0
Downloads
0
Citations
Publication Record
Distribution of Articles published per year 

Total number of journals
published in
 
1
 
Publications
Article 0 Reads 0 Citations An Organic Chemist’s Guide to Electrospray Mass Spectrometric Structure Elucidation Arnold Steckel, Gitta Schlosser Published: 10 February 2019
Molecules, doi: 10.3390/molecules24030611
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Tandem mass spectrometry is an important tool for structure elucidation of natural and synthetic organic products. Fragmentation of odd electron ions (OE+) generated by electron ionization (EI) was extensively studied in the last few decades, however there are only a few systematic reviews available concerning the fragmentation of even-electron ions (EE+/EE−) produced by the currently most common ionization techniques, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). This review summarizes the most important features of tandem mass spectra generated by collision-induced dissociation fragmentation and presents didactic examples for the unexperienced users.
Article 0 Reads 0 Citations Ferrocene-Containing Impiridone (ONC201) Hybrids: Synthesis, DFT Modelling, In Vitro Evaluation, and Structure–Activity ... Péter Bárány, Rita Szabó Oláh, Imre Kovács, Tamás Czuczi, Cs... Published: 03 September 2018
Molecules, doi: 10.3390/molecules23092248
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Inspired by the well-established clinical evidence about the interplay between apoptotic TRAIL (tumour necrosis factor-related apoptosis-inducing ligand) mechanism and reactive oxygen species (ROS)-mediated oxidative stress, a set of novel ONC201 hybrids containing the impiridone core and one or two differently positioned ferrocenylalkyl groups were synthesised in our present work. These two types of residues have been implicated in the aforementioned mechanisms associated with cytotoxic activity. A straightforward, primary amine-based synthetic approach was used allowing the introduction of a variety of N-substituents into the two opposite regions of the heterocyclic skeleton. Reference model compounds with benzyl and halogenated benzyl groups were also synthesised and tested. The in vitro assays of the novel impiridones on five malignant cell lines disclosed characteristic structure-activity relationship (SAR) featuring significant substituent-dependent activity and cell-selectivity. A possible contribution of ROS-mechanism to the cytotoxicity of the novel metallocenes was suggested by density functional theory (DFT)studies on simplified models. Accordingly, unlike the mono-ferrocenylalkyl-substituted products, the compounds containing two ferrocenylalkyl substituents in the opposite regions of the impiridone core display a much more pronounced long-term cytotoxic effect against A-2058 cell line than do the organic impiridones including ONC201 and ONC212. Furthermore, the prepared bis-metallocene derivatives also present substantial activity against COLO-205- and EBC-1 cell lines.
Article 0 Reads 0 Citations Photochemical and Structural Studies on Cyclic Peptide Models Tamás Milán Nagy, Krisztina Knapp, Eszter Illyés, István Tim... Published: 30 August 2018
Molecules, doi: 10.3390/molecules23092196
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Ultra-violet (UV) irradiation has a significant impact on the structure and function of proteins that is supposed to be in relationship with the tryptophan-mediated photolysis of disulfide bonds. To investigate the correlation between the photoexcitation of Trp residues in polypeptides and the associated reduction of disulfide bridges, a series of small, cyclic oligopeptide models were analyzed in this work. Average distances between the aromatic side chains and the disulfide bridge were determined following molecular mechanics (MM) geometry optimizations. In this way, the possibility of cation–π interactions was also investigated. Molecular mechanics calculations revealed that the shortest distance between the side chain of the Trp residues and the disulfide bridge is approximately 5 Å in the cyclic pentapeptide models. Based on this, three tryptophan-containing cyclopeptide models were synthesized and analyzed by nuclear magnetic resonance (NMR) spectroscopy. Experimental data and detailed molecular dynamics (MD) simulations were in good agreement with MM geometry calculations. Selected model peptides were subjected to photolytic degradation to study the correlation of structural features and the photolytic cleavage of disulfide bonds in solution. Formation of free sulfhydryl groups upon illumination with near UV light was monitored by fluorescence spectroscopy after chemical derivatization with 7-diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin (CPM) and mass spectrometry. Liquid cromatography-mass spectrometry (LC-MS) measurements indicated the presence of multiple photooxidation products (e.g., dimers, multimers and other oxidated products), suggesting that besides the photolysis of disulfide bonds secondary photolytic processes take place.
Top