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Emilio Carbone  - - - 
Top co-authors See all
Joerg Striessnig

195 shared publications

Abteilung Pharmakologie und Toxikologie, Institut für Pharmazie, and Center for Molecular Biosciences Innsbruck, Universität Innsbruck, A-6020 Innsbruck, Austria

Christopher J. Lingle

75 shared publications

Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA

Valentina Carabelli

64 shared publications

Drug Science and Technology Department, Inter-departmental Center (NIS), University of Torino, Torino, Italy

Emanuele Enrico

56 shared publications

Istituto Nazionale di Ricerca Metrologica, Torino, Piemonte, ITALY

Andrea Marcantoni

43 shared publications

Department of Drug Science, University of Torino, Torino, Italy

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Distribution of Articles published per year 
(1991 - 2019)
Total number of journals
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23
 
Publications See all
Article 1 Read 0 Citations Impaired chromaffin cell excitability and exocytosis in autistic Timothy syndrome TS2‐neo mouse rescued by L‐type calciu... Chiara Calorio, Daniela Gavello, Laura Guarina, Chiara Salio... Published: 28 January 2019
The Journal of Physiology, doi: 10.1113/jp277487
DOI See at publisher website
BOOK-CHAPTER 0 Reads 0 Citations Diamond-Based Multi Electrode Arrays for Monitoring Neurotransmitter Release Giulia Tomagra, Alfio Battiato, Ettore Bernardi, Alberto Pas... Published: 18 January 2019
On Stochastic Optimization Problems and an Application in Finance, doi: 10.1007/978-3-030-04324-7_17
DOI See at publisher website
Article 2 Reads 2 Citations Nanodiamonds-induced effects on neuronal firing of mouse hippocampal microcircuits L. Guarina, C. Calorio, D. Gavello, E. Moreva, P. Traina, A.... Published: 02 February 2018
Scientific Reports, doi: 10.1038/s41598-018-20528-5
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Fluorescent nanodiamonds (FND) are carbon-based nanomaterials that can efficiently incorporate optically active photoluminescent centers such as the nitrogen-vacancy complex, thus making them promising candidates as optical biolabels and drug-delivery agents. FNDs exhibit bright fluorescence without photobleaching combined with high uptake rate and low cytotoxicity. Focusing on FNDs interference with neuronal function, here we examined their effect on cultured hippocampal neurons, monitoring the whole network development as well as the electrophysiological properties of single neurons. We observed that FNDs drastically decreased the frequency of inhibitory (from 1.81 Hz to 0.86 Hz) and excitatory (from 1.61 to 0.68 Hz) miniature postsynaptic currents, and consistently reduced action potential (AP) firing frequency (by 36%), as measured by microelectrode arrays. On the contrary, bursts synchronization was preserved, as well as the amplitude of spontaneous inhibitory and excitatory events. Current-clamp recordings revealed that the ratio of neurons responding with AP trains of high-frequency (fast-spiking) versus neurons responding with trains of low-frequency (slow-spiking) was unaltered, suggesting that FNDs exerted a comparable action on neuronal subpopulations. At the single cell level, rapid onset of the somatic AP (“kink”) was drastically reduced in FND-treated neurons, suggesting a reduced contribution of axonal and dendritic components while preserving neuronal excitability.
Article 0 Reads 0 Citations p140Cap Regulates GABAergic Synaptogenesis and Development of Hippocampal Inhibitory Circuits Isabella Russo, Daniela Gavello, Elisabetta Menna, David Van... Published: 17 November 2017
Cerebral Cortex, doi: 10.1093/cercor/bhx306
DOI See at publisher website
Article 3 Reads 0 Citations Old and emerging concepts on adrenal chromaffin cell stimulus-secretion coupling Ricardo Borges, Luis Gandía, Emilio Carbone Published: 06 November 2017
Pflügers Archiv - European Journal of Physiology, doi: 10.1007/s00424-017-2082-z
DOI See at publisher website PubMed View at PubMed
Article 2 Reads 3 Citations Roles of Na+, Ca2+, and K+ channels in the generation of repetitive firing and rhythmic bursting in adrenal chromaffin c... Christopher J. Lingle, Pedro L. Martinez-Espinosa, Laura Gua... Published: 03 August 2017
Pflügers Archiv - European Journal of Physiology, doi: 10.1007/s00424-017-2048-1
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Adrenal chromaffin cells (CCs) are the main source of circulating catecholamines (CAs) that regulate the body response to stress. Release of CAs is controlled neurogenically by the activity of preganglionic sympathetic neurons through trains of action potentials (APs). APs in CCs are generated by robust depolarization following the activation of nicotinic and muscarinic receptors that are highly expressed in CCs. Bovine, rat, mouse, and human CCs also express a composite array of Na+, K+, and Ca2+ channels that regulate the resting potential, shape the APs, and set the frequency of AP trains. AP trains of increasing frequency induce enhanced release of CAs. If the primary role of CCs is simply to relay preganglionic nerve commands to CA secretion, why should they express such a diverse set of ion channels? An answer to this comes from recent observations that, like in neurons, CCs undergo complex firing patterns of APs suggesting the existence of an intrinsic CC excitability (non-neurogenically controlled). Recent work has shown that CCs undergo occasional or persistent burst firing elicited by altered physiological conditions or deletion of pore-regulating auxiliary subunits. In this review, we aim to give a rationale to the role of the many ion channel types regulating CC excitability. We will first describe their functional properties and then analyze how they contribute to pacemaking, AP shape, and burst waveforms. We will also furnish clear indications on missing ion conductances that may be involved in pacemaking and highlight the contribution of the crucial channels involved in burst firing.
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