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V. Stone  - - - 
Top co-authors See all
Lang Tran

202 shared publications

Macao Sino-Portuguese Nurses Association; Macao China

Bernd Nowack

194 shared publications

Empa − Swiss Federal Laboratories for Materials Science and Technology, Technology and Society Laboratory, Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland

Paul Fowler

164 shared publications

University of Aberdeen

V. Stone

160 shared publications

Nano Safety Research Group, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom

Teresa Fernandes

138 shared publications

Faculty of Economics, University of Porto, Porto, Portugal

159
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Publication Record
Distribution of Articles published per year 
(1878 - 2018)
Total number of journals
published in
 
33
 
Publications See all
Article 0 Reads 0 Citations A cross-species and model comparison of the acute toxicity of nanoparticles used in the pigment and ink industries David M. Brown, Helinor J. Johnston, Birgit Gaiser, Nicola P... Published: 01 July 2018
NanoImpact, doi: 10.1016/j.impact.2018.02.001
DOI See at publisher website
Article 4 Reads 2 Citations Transformations of Nanoenabled Copper Formulations Govern Release, Antifungal Effectiveness, and Sustainability througho... Daniele Pantano, Nicole Neubauer, Jana Navrátilová, Lorette ... Published: 26 January 2018
Environmental Science & Technology, doi: 10.1021/acs.est.7b04130
DOI See at publisher website
Article 0 Reads 0 Citations Cover Image Pedro M. Costa, Ilse Gosens, Andrew Williams, Lucian Farcal,... Published: 23 January 2018
Journal of Applied Toxicology, doi: 10.1002/jat.3600
DOI See at publisher website
Article 1 Read 4 Citations Adoption of in vitro systems and zebrafish embryos as alternative models for reducing rodent use in assessments of immun... Helinor J. Johnston, Rachel Verdon, Suzanne Gillies, David M... Published: 14 December 2017
Critical Reviews in Toxicology, doi: 10.1080/10408444.2017.1404965
DOI See at publisher website PubMed View at PubMed
Article 1 Read 2 Citations Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state Angela A.M. Kämpfer, Patricia Urbán, Sabrina Gioria, Nilesh ... Published: 01 December 2017
Toxicology in Vitro, doi: 10.1016/j.tiv.2017.08.011
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
The intestine forms the largest interface between the environment and the human organism. Its integrity and functioning are crucial for the uptake of nutrients while preventing access of harmful antigens. Inflammatory conditions can significantly change the normal functioning of the intestine. In vitro models that adequately reproduce both healthy and inflamed intestinal tissue could provide a useful tool for studying the mechanisms of intestinal inflammation and investigating new therapeutic drugs. We established a co-culture of Caco-2 and PMA-differentiated THP-1 cells that mimics the intestine in healthy and controlled inflamed states. In homoeostatic conditions without stimulation, Caco-2 and THP-1 cells were co-cultured for 48h without affecting the barrier integrity and with no increase in the release of cytokines, nitric oxide or lactate dehydrogenase. To simulate the inflamed intestine, the Caco-2 barrier was primed with IFN-γ and THP-1 cells were pre-stimulated with LPS and IFN-γ. In these conditions a significant but temporary reduction in barrier integrity was measured, and large concentrations of pro-inflammatory cytokines and cytotoxicity markers detected. With its ability to feature numerous hallmarks of intestinal inflammation the presented co-culture model of epithelial cells and macrophages offers a unique possibility to study exposure effects in relation to the health status of the intestine.
Article 1 Read 1 Citation Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long-term opportunities? Natalie Burden, Karin Aschberger, Qasim Chaudhry, Martin J.D... Published: 01 December 2017
Regulatory Toxicology and Pharmacology, doi: 10.1016/j.yrtph.2017.10.021
DOI See at publisher website PubMed View at PubMed
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