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Vicki Stone  - - - 
Top co-authors See all
Ulla Vogel

274 shared publications

Nationale Forskningscenter for Arbejdsmiljo

Bernd Nowack

170 shared publications

Empa; Swiss Federal Laboratories for Materials Science and Technology; St. Gallen Switzerland

Vicki Stone

90 shared publications

Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh, Scotland, UK

Teresa Fernandes

86 shared publications

School of Life Sciences, Heriot-Watt University, Edinburgh, UK

Stephen Doak

83 shared publications

In Vitro Toxicology Group, Institute of Life Science and Centre for NanoHealth, Swansea Univeristy Medical School, Swansea University, Singleton Park, Swansea SA2 8PP, Wales, UK

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Publication Record
Distribution of Articles published per year 
(2000 - 2017)
Total number of journals
published in
 
29
 
Publications See all
Article 0 Reads 0 Citations SUNDS probabilistic human health risk assessment methodology and its application to organic pigment used in the automoti... Lisa Pizzol, Danail Hristozov, Alex Zabeo, Gianpietro Basei,... Published: 01 January 2019
NanoImpact, doi: 10.1016/j.impact.2018.12.001
DOI See at publisher website
Article 0 Reads 0 Citations Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape Ali Kermanizadeh, Leagh G Powell, Vicki Stone, Peter Møller Published: 01 November 2018
International Journal of Nanomedicine, doi: 10.2147/ijn.s177418
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Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape Ali Kermanizadeh,1,2 Leagh G Powell,1 Vicki Stone,1 Peter Møller2 1NanoSafety Research Group, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK; 2Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark The use of nanoparticles as a means of targeted delivery of therapeutics and imaging agents could greatly enhance the transport of biologically active contents to specific target tissues, while avoiding or reducing potentially undesired side effects. Generally speaking, the oral route of administration is associated with good patient compliance, as it is convenient, economical, noninvasive, and does not require special training. Here, we review the progress of the utilization of nanodelivery-system carriers or stabilized solid-drug nanoparticles following oral administration, with particular attention on toxicological data. Mechanisms of cytotoxicity are discussed and the problem of extrapolating knowledge to human scenarios highlighted. Additionally, issues associated with administration of drugs via the oral route are underlined, while strategies utilized to overcome these are highlighted. This review aims to offer a balanced overview of strategies currently being used in the application of nanosize constructs for oral medical applications. Keywords: nanomedicine, oral route of delivery, nanomaterials, nano-stabilized solid drugs
Article 1 Read 4 Citations The effect of aluminium and sodium impurities on the in vitro toxicity and pro-inflammatory potential of cristobalite C. Nattrass, C.J. Horwell, D.E. Damby, D. Brown, V. Stone Published: 01 November 2017
Environmental Research, doi: 10.1016/j.envres.2017.07.054
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Exposure to crystalline silica (SiO2), in the form of quartz, tridymite or cristobalite, can cause respiratory diseases, such as silicosis. However, the observed toxicity and pathogenicity of crystalline silica is highly variable. This has been attributed to a number of inherent and external factors, including the presence of impurities. In cristobalite-rich dusts, substitutions of aluminium (Al) for silicon (Si) in the cristobalite structure, and impurities occluding the silica surface, have been hypothesised to decrease its toxicity. This hypothesis is tested here through the characterisation and in vitro toxicological study of synthesised cristobalite with incremental amounts of Al and sodium (Na) dopants.
Article 1 Read 22 Citations Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge Vicki Stone, Mark R. Miller, Martin J.D. Clift, Alison Elder... Published: 03 October 2017
Environmental Health Perspectives, doi: 10.1289/ehp424
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Article 1 Read 6 Citations The 3Rs as a framework to support a 21st century approach for nanosafety assessment Natalie Burden, Karin Aschberger, Qasim Chaudhry, Martin J.D... Published: 01 February 2017
Nano Today, doi: 10.1016/j.nantod.2016.06.007
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Due to the plethora of nanomaterials being manufactured, it is crucial that their effects on human health are understood. It is not feasible to assess the safety of all nanomaterials using animal-based toxicity tests. There are also scientific, business, legislative and ethical drivers to reconsider the use of such toxicity tests. Utilising non-traditional methods has the potential to improve the human relevance of nanosafety assessment, reduce the numbers of animals that are used, and shift the paradigm to a ‘21st century’ approach that exploits recent scientific and technological advances. This article considers how application of the 3Rs principles can be used as a framework to support and guide this paradigm shift in the short, medium and long-term. Bringing the community together to facilitate the transition is necessary to ensure that tangible impacts are made on the efficiency and robustness of the nanosafety assessment process.
Article 1 Read 6 Citations Approaches to Develop Alternative Testing Strategies to Inform Human Health Risk Assessment of Nanomaterials Vicki Stone, Helinor J. Johnston, Dominique Balharry, Jeremy... Published: 10 June 2016
Risk Analysis, doi: 10.1111/risa.12645
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