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Vicki Stone  - - - 
Top co-authors See all
Bert Brunekreef

512 shared publications

Institute for Risk Assessment Sciences (IRAS), Division of Environmental Epidemiology, Utrecht University, 3584 CK Utrecht, The Netherlands

William MacNee

413 shared publications

University of EdinburghEdinburgh, United Kingdom

Francesco Forastiere

358 shared publications

Clinica Tisiologica e Pneumologica, Dipartimento di Medicina Interna e Specialità Mediche, Università degli Studi di Genova, Italy

David E. Newby

278 shared publications

Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK

Jürgen Lademann

239 shared publications

Department of Dermatology, Venerology and Allergology, Charité – Universitätsmedizin Berlin, Berlin, Germany

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Distribution of Articles published per year 
(2000 - 2019)
Total number of journals
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34
 
Publications See all
Article 0 Reads 0 Citations The influence of organic modification on the cytotoxicity of clay particles to keratinocytes, hepatocytes and macrophage... Mona Connolly, Yu Zhang, Sohaib Mahri, David M. Brown, Natal... Published: 01 April 2019
Food and Chemical Toxicology, doi: 10.1016/j.fct.2019.02.015
DOI See at publisher website PubMed View at PubMed
Article 0 Reads 0 Citations SUNDS probabilistic human health risk assessment methodology and its application to organic pigment used in the automoti... Lisa Pizzol, Danail Hristozov, Alex Zabeo, Gianpietro Basei,... Published: 01 January 2019
NanoImpact, doi: 10.1016/j.impact.2018.12.001
DOI See at publisher website
Article 0 Reads 0 Citations Toxicity of copper oxide and basic copper carbonate nanoparticles after short-term oral exposure in rats. Wim H. De Jong, Eveline De Rijk, Alessandro Bonetto, Wendel ... Published: 19 November 2018
Nanotoxicology, doi: 10.1080/17435390.2018.1530390
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Copper oxide (CuO) nanoparticles (NPs) and copper carbonate nanoparticles (Cu2CO3(OH)2 NPs have applications as antimicrobial agents and wood preservatives: an application that may lead to oral ingestion via hand to mouth transfer. Rats were exposed by oral gavage to CuO NPs and Cu2CO3(OH)2 NPs for five consecutive days with doses from 1 to 512 mg/kg and 4 to 128 mg/kg per day, respectively, and toxicity was evaluated at days 6 and 26. Both CuO NPs and Cu2CO3(OH)2 NPs induced changes in hematology parameters, as well as clinical chemistry markers (e.g. increased alanine aminotransferase, ALT) indicative of liver damage For CuO NPs histopathological alterations were observed in bone marrow, stomach and liver mainly consisting of an inflammatory response, ulceration, and degeneration. Cu2CO3(OH)2 NPs induced morphological alterations in the stomach, liver, intestines, spleen, thymus, kidneys, and bone marrow. In spleen and thymus lymphoid, depletion was noted that warrants further immunotoxicological evaluation. The NPs showed partial dissolution in artificial simulated stomach fluids, while in intestinal conditions, the primary particles simultaneously shrank and agglomerated into large structures. This means that both copper ions and the particulate nanoforms should be considered as potential causal agents for the observed toxicity. For risk assessment, the lowest bench mark dose (BMD) was similar for both NPs for the serum liver enzyme AST (an indication of liver toxicity), being 26.2 mg/kg for CuO NPs and 30.8 mg/kg for Cu2CO3(OH)2 NPs. This was surprising since the histopathology evidence demonstrates more severe organ damage for Cu2CO3(OH)2 NPs than for CuO NPs.
Article 0 Reads 1 Citation Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine: current landscape Ali Kermanizadeh, Leagh G Powell, Vicki Stone, Peter Møller Published: 16 November 2018
International Journal of Nanomedicine, doi: 10.2147/ijn.s177418
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The use of nanoparticles as a means of targeted delivery of therapeutics and imaging agents could greatly enhance the transport of biologically active contents to specific target tissues, while avoiding or reducing potentially undesired side effects. Generally speaking, the oral route of administration is associated with good patient compliance, as it is convenient, economical, noninvasive, and does not require special training. Here, we review the progress of the utilization of nanodelivery-system carriers or stabilized solid-drug nanoparticles following oral administration, with particular attention on toxicological data. Mechanisms of cytotoxicity are discussed and the problem of extrapolating knowledge to human scenarios highlighted. Additionally, issues associated with administration of drugs via the oral route are underlined, while strategies utilized to overcome these are highlighted. This review aims to offer a balanced overview of strategies currently being used in the application of nanosize constructs for oral medical applications.
Article 0 Reads 0 Citations Assessing the bioactivity of crystalline silica in heated high-temperature insulation wools Matthew S. P. Boyles, David Brown, Jilly Knox, Michael Horob... Published: 17 October 2018
Inhalation Toxicology, doi: 10.1080/08958378.2018.1513610
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
High-Temperature Insulation Wools (HTIW), such as alumino silicate wools (Refractory Ceramic Fibers) and Alkaline Earth Silicate wools, are used in high-temperature industries for thermal insulation. These materials have an amorphous glass-like structure. In some applications, exposure to high temperatures causes devitrification resulting in the formation of crystalline species including crystalline silica. The formation of this potentially carcinogenic material raises safety concerns regarding after-use handling and disposal. This study aims to determine whether cristobalite formed in HTIW is bioactive in vitro. Mouse macrophage (J774A.1) and human alveolar epithelial (A549) cell lines were exposed to pristine HTIW of different compositions, and corresponding heat-treated samples. Cell death, cytokine release, and reactive oxygen species (ROS) formation were assessed in both cell types. Cell responses to aluminum lactate-coated fibers were assessed to determine if responses were caused by crystalline silica. DQ12 α-quartz was used as positive control, and TiO2 as negative control. HTIW did not induce cell death or intracellular ROS, and their ability to induce pro-inflammatory mediator release was low. In contrast, DQ12 induced cytotoxicity, a strong pro-inflammatory response and ROS generation. The modest pro-inflammatory mediator responses of HTIW did not always coincide with the formation of cristobalite in heated fibers; therefore, we cannot confirm that devitrification of HTIW results in bioactive cristobalite in vitro. In conclusion, the biological responses to HTIW observed were not attributable to a single physicochemical characteristic; instead, a combination of physicochemical characteristics (cristobalite content, fiber chemistry, dimensions and material solubility) appear to contribute to induction of cellular responses.
Article 0 Reads 0 Citations A cross-species and model comparison of the acute toxicity of nanoparticles used in the pigment and ink industries David M. Brown, Helinor J. Johnston, Birgit Gaiser, Nicola P... Published: 01 July 2018
NanoImpact, doi: 10.1016/j.impact.2018.02.001
DOI See at publisher website
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