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Thomas Nann  - - - 
Top co-authors See all
Ivan P. Parkin

711 shared publications

Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, U.K.

Nicolas H. Voelcker

240 shared publications

Drug DeliveryDisposition and DynamicsMonash Institute of Pharmaceutical SciencesMonash University Parkville Victoria 3052 Australia

Thomas Nann

164 shared publications

MacDiarmid Institute for Advanced Materials and Nanotechnology, Wellington, New Zealand

Steven J. P. McInnes

35 shared publications

University of South Australia, Adelaide, Australia

Nathan Hollingsworth

21 shared publications

Department of Chemistry, University College London, London WC1H 0AJ, UK;(N.H.);(I.P.P.)

157
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Publication Record
Distribution of Articles published per year 
(2000 - 2019)
Total number of journals
published in
 
30
 
Publications See all
Article 1 Read 0 Citations Size-controlled, high optical quality ZnO nanowires grown using colloidal Au nanoparticles and ultra-small cluster catal... M. F. Lynam, N.-J. Ke, S. J. Bradley, T. Nann, A. Neiman, R.... Published: 01 February 2019
APL Materials, doi: 10.1063/1.5054355
DOI See at publisher website
Article 3 Reads 0 Citations An In Vitro Investigation of Cytotoxic Effects of InP/Zns Quantum Dots with Different Surface Chemistries Deanna Ayupova, Garima Dobhal, Geoffry Laufersky, Thomas Nan... Published: 22 January 2019
Nanomaterials, doi: 10.3390/nano9020135
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Indium phosphide quantum dots (QDs) passivated with zinc sulphide in a core/shell architecture (InP/ZnS) with different surface chemistries were introduced to RAW 264.7 murine “macrophage-like” cells to understand their potential toxicities. The InP/ZnS quantum dots were conjugated with an oligonucleotide, a carboxylic acid, or an amino-polyethylene glycol ligand, and cell viability and cell proliferation were investigated via a metabolic assay. Membrane integrity was measured through the production of lactate dehydrogenase. Fluorescence microscopy showed cellular uptake. All quantum dots exhibited cytotoxic behaviour less than that observed from cadmium- or lead-based quantum dots; however, this behaviour was sensitive to the ligands used. In particular, the amino-polyethylene glycol conjugated quantum dots proved to possess the highest cytotoxicity examined here. This provides quantitative evidence that aqueous InP/ZnS quantum dots can offer a safer alternative for bioimaging or in therapeutic applications.
Article 0 Reads 0 Citations Copper Metallopolymer Catalyst for the Electrocatalytic Hydrogen Evolution Reaction (HER) Sait Elmas, Thomas J. Macdonald, William Skinner, Mats Ander... Published: 10 January 2019
Polymers, doi: 10.3390/polym11010110
DOI See at publisher website ABS Show/hide abstract
Conjugated polymers with stabilizing coordination units for single-site catalytic centers are excellent candidates to minimize the use of expensive noble metal electrode materials. In this study, conjugated metallopolymer, POS[Cu], was synthesized and fully characterized by means of spectroscopical, electrochemical, and photophysical methods. The copper metallopolymer was found to be highly active for the electrocatalytic hydrogen generation (HER) in an aqueous solution at pH 7.4 and overpotentials at 300 mV vs. reversible hydrogen electrode (RHE). Compared to the platinum electrode, the obtained overpotential is only 100 mV higher. The photoelectrochemical tests revealed that the complexation of the conjugated polymer POS turned its intrinsically electron-accepting (p-type) properties into an electron-donor (n-type) with photocurrent responses ten times higher than the organic photoelectrode.
BOOK-CHAPTER 0 Reads 0 Citations Physical Chemistry of Nanoparticle Syntheses Geoffry Laufersky, Thomas Nann Published: 01 January 2019
Comprehensive Nanoscience and Nanotechnology, doi: 10.1016/b978-0-12-803581-8.11342-6
DOI See at publisher website
Article 2 Reads 1 Citation Cadmium-Free Quantum Dots as Fluorescent Labels for Exosomes Garima Dobhal, Deanna Ayupova, Geoffry Laufersky, Zeineb Aye... Published: 02 October 2018
Sensors, doi: 10.3390/s18103308
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Quantum dots are attractive alternatives to organic fluorophores for the purposes of fluorescent labeling and the detection of biomarkers. They can also be made to specifically target a protein of interest by conjugating biomolecules, such as antibodies. However, the majority of the fluorescent labeling using quantum dots is done using toxic materials such as cadmium or lead due to the well-established synthetic processes for these quantum dots. Here, we demonstrate the use of indium phosphide quantum dots with a zinc sulfide shell for the purposes of labeling and the detection of exosomes derived from the THP-1 cell line (monocyte cell line). Exosomes are nano-sized vesicles that have the potential to be used as biomarkers due to their involvement in complex cell processes. However, the lack of standardized methodology around the detection and analysis of exosomes has made it difficult to detect these membrane-containing vesicles. We targeted a protein that is known to exist on the surface of the exosomes (CD63) using a CD63 antibody. The antibody was conjugated to the quantum dots that were first made water-soluble using a ligand-exchange method. The conjugation was done using carbodiimide coupling, and was confirmed using a range of different methods such as dynamic light scattering, surface plasmon resonance, fluorescent microscopy, and Fourier transform infrared spectroscopy. The conjugation of the quantum dot antibody to the exosomes was further confirmed using similar methods. This demonstrates the potential for the use of a non-toxic conjugate to target nano-sized biomarkers that could be further used for the detection of different diseases.
Article 1 Read 1 Citation Conducting Copper(I/II)-Metallopolymer for the Electrocatalytic Oxygen Reduction Reaction (ORR) with High Kinetic Curren... Sait Elmas, Wesley Beelders, Xun Pan, Thomas Nann Published: 07 September 2018
Polymers, doi: 10.3390/polym10091002
DOI See at publisher website ABS Show/hide abstract
The oxygen reduction reaction (ORR) is still the most research-intensive aspect of a fuel cell. The sluggish kinetics of the electrocatalysts toward the ORR requires large amounts of platinum to be used as cathode material, which calls for alternatives to replace or minimize the amount of the noble metals used. This study describes the synthesis and complete characterization of a copper metallopolymer (Cu MP) based on a conducting polymer (CP) and single-site catalytic centers for the electrocatalytic ORR. The copper (II) catalyst, embedded in a redox-active and conducting polymeric environment, was pursued as a potential candidate to replace noble metals in fuel cell applications. Performance studies at a rotating disk electrode (RDE) showed that the metallopolymer exhibited a direct four-electron reduction at potentials between −150 and −350 mV vs. the reversible hydrogen electrode (RHE) and high kinetic current densities of over 22.62 mA/cm2. The kinetic current densities obtained at the Cu MP electrode outperformed most of the reported state-of-the art electrocatalysts toward the ORR. Further analysis of the Cu/CP hybrid revealed the copper being largely reduced to the oxidation state +I.
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