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Ulla Vogel  - - - 
Top co-authors See all
Anne Tjønneland

939 shared publications

Unit of Diet, Genes and Environment, Danish Cancer Society Research Center

Håkan Wallin

601 shared publications

National Research Centre for the Working Environment, 2100 Copenhagen, Denmark

Vicki Stone

164 shared publications

Heriot-Watt University, Riccarton Campus, Edinburgh, EH14 4AS, United Kingdom

Paal Skytt Andersen

138 shared publications

The Department of Microbiology and Infection Control, Statens Serum Institut (SSI), Copenhagen, Denmark

Vibeke Andersen

117 shared publications

10Focused Research Unit for Molecular Diagnostic and Clinical Research, Hospital of Southern Jutland, Aabenraa, Denmark

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Publication Record
Distribution of Articles published per year 
(2004 - 2018)
Total number of journals
published in
 
21
 
Publications See all
Article 0 Reads 0 Citations Effects of maternal inhalation of carbon black nanoparticles on reproductive and fertility parameters in a four-generati... Astrid Skovmand, Alexander C. Ø. Jensen, Clotilde Maurice, F... Published: 18 March 2019
Particle and Fibre Toxicology, doi: 10.1186/s12989-019-0295-3
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Previous findings indicate that in utero exposure to nanoparticles may affect the reproductive system in male offspring. Effects such as decreased sperm counts and testicular structural changes in F1 males have been reported following maternal airway exposure to carbon black during gestation. In addition, a previous study in our laboratory suggested that the effects of in utero exposure of nanoparticles may span further than the first generation, as sperm content per gram of testis was significantly lowered in F2 males. In the present study we assessed male fertility parameters following in utero inhalation exposure to carbon black in four generations of mice. Filter measurements demonstrated that the time-mated females were exposed to a mean total suspended particle mass concentration of 4.79 ± 1.86 or 33.87 ± 14.77 mg/m3 for the low and high exposure, respectively. The control exposure was below the detection limit (LOD 0.08 mg/m3). Exposure did not affect gestation and litter parameters in any generation. No significant changes were observed in body and reproductive organ weights, epididymal sperm parameters, daily sperm production, plasma testosterone or fertility. In utero exposure to carbon black nanoparticles, at occupationally relevant exposure levels, via maternal whole body inhalation did not affect male-specific reproductive, fertility and litter parameters in four generations of mice.
Article 0 Reads 0 Citations Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study Daniele Campa, Alessandro Martino, Angelica Macauda, Marek D... Published: 11 January 2019
Leukemia & Lymphoma, doi: 10.1080/10428194.2018.1551536
DOI See at publisher website
PREPRINT-CONTENT 0 Reads 0 Citations Intake of red and processed meat, use of non-steroid anti-inflammatory drugs, genetic variants and risk of colorectal ca... Vibeke Andersen, Ulrich Halekoh, Anne Tjønneland, Ulla Vogel... Published: 14 December 2018
bioRxiv, doi: 10.1101/496968
DOI See at publisher website ABS Show/hide abstract
Red and processed meat have been associated with increased risk of colorectal cancer (CRC), whereas long-term use of non-steroid anti-inflammatory drugs (NSAIDs) may reduce the risk. The aim was to investigate potential interactions between meat intake, NSAID use, and gene variants in fatty acid metabolism and NSAID pathways in relation to the risk of CRC. A nested case-cohort study of 1038 CRC cases and 1857 randomly selected participants from the Danish prospective “Diet, Cancer and Health” study encompassing 57,053 persons was performed using the Cox proportional hazard models. Gene variants in SLC25A20, PRKAB1, LPCAT1, PLA2G4A, ALOX5, PTGER3, TP53, CCAT2, TCF7L2, BCL2 were investigated. CCAT2 rs6983267 was associated with risk of CRC per se (p
Article 0 Reads 3 Citations Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment Bengt Fadeel, Cyrill Bussy, Sonia Merino, Ester Vázquez, Emm... Published: 02 November 2018
ACS Nano, doi: 10.1021/acsnano.8b04758
DOI See at publisher website
Article 0 Reads 0 Citations Physicochemical predictors of Multi-Walled Carbon Nanotube-induced pulmonary histopathology and toxicity one year after ... Kristina Bram Knudsen, Trine Berthing, Petra Jackson, Sarah ... Published: 18 October 2018
Basic & Clinical Pharmacology & Toxicology, doi: 10.1111/bcpt.13119
DOI See at publisher website ABS Show/hide abstract
Multi‐walled carbon nanotubes (MWCNT) are widely used nanomaterials that cause pulmonary toxicity upon inhalation. The physicochemical properties of MWCNT vary greatly, which makes general safety evaluation challenging to conduct. Identification of the toxicity‐inducing physicochemical properties of MWCNT is therefore of great importance. We have evaluated histological changes in lung tissue 1year after a single intratracheal instillation of 11 well‐characterized MWCNT in female C57BL/6N BomTac mice. Genotoxicity of liver and spleen was evaluated by the Comet assay. The dose of 54 μg MWCNT corresponds to three times the estimated dose accumulated during a work life at a NIOSH recommended exposure limit (0.001 mg/m3). Short and thin MWCNT were observed as agglomerates in lung tissue 1 year after exposure, whereas thicker and longer MWCNT were detected as single fibres, suggesting biopersistence of both types of MWCNT. The thin and entangled MWCNT induced varying degree of pulmonary inflammation, in terms of lymphocytic aggregates, granulomas and macrophage infiltration, whereas two thick and straight MWCNT did not. By multiple regression analysis, larger diameter and higher content of iron predicted less histopathological changes, whereas higher cobalt content significantly predicted more histopathological changes. No MWCNT‐related fibrosis or tumours in the lungs or pleura was found. One thin and entangled MWCNT induced increased levels of DNA strand breaks in liver; however, no physicochemical properties could be related to genotoxicity. This study reveals physicochemical‐dependent difference in MWCNT‐induced long‐term, pulmonary histopathological changes. Identification of diameter size and cobalt content as important for MWCNT toxicity provides clues for designing MWCNT, which cause reduced human health effects following pulmonary exposure. This article is protected by copyright. All rights reserved.
Article 0 Reads 1 Citation Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased ris... Jacob Sode, Steffen Bank, Ulla Vogel, Paal Skytt Andersen, S... Published: 12 September 2018
BMC Medical Genetics, doi: 10.1186/s12881-018-0680-z
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Ankylosing spondylitis (AS) results from the combined effects of susceptibility genes and environmental factors. Polymorphisms in genes regulating inflammation may explain part of the heritability of AS. Using a candidate gene approach in this case-control study, 51 mainly functional single nucleotide polymorphisms (SNPs) in genes regulating inflammation were assessed in 709 patients with AS and 795 controls. Data on the patients with AS were obtained from the DANBIO registry where patients from all of Denmark are monitored in routine care during treatment with conventional and biologic disease modifying anti-rheumatic drugs (bDMARDs). The results were analyzed using logistic regression (adjusted for age and sex). Nine polymorphisms were associated with risk of AS (p < 0.05). The polymorphisms were in genes regulating a: the TNF-α pathway (TNF -308 G > A (rs1800629), and − 238 G > A (rs361525); TNFRSF1A -609 G > T (rs4149570), and PTPN22 1858 G > A (rs2476601)), b: the IL23/IL17 pathway (IL23R G > A (rs11209026), and IL18–137 G > C (rs187238)), or c: the NFkB pathway (TLR1 743 T > C (rs4833095), TLR4 T > C (rs1554973), and LY96–1625 C > G (rs11465996)). After Bonferroni correction the homozygous variant genotype of TLR1 743 T > C (rs4833095) (odds ratios (OR): 2.59, 95% confidence interval (CI): 1.48–4.51, p = 0.04), and TNFRSF1A -609 G > T (rs4149570) (OR: 1.79, 95% CI: 1.31–2.41, p = 0.01) were associated with increased risk of AS and the combined homozygous and heterozygous variant genotypes of TNF -308 G > A (rs1800629) (OR: 0.56, 95% CI: 0.44–0.72, p = 0.0002) were associated with reduced risk of AS. We replicated associations between AS and the polymorphisms in TNF (rs1800629), TNFRSF1A (rs4149570), and IL23R (rs11209026). Furthermore, we identified novel risk loci in TNF (rs361525), IL18 (rs187238), TLR1 (rs4833095), TLR4 (rs1554973), and LY96 (rs11465996) that need validation in independent cohorts. The results suggest that genetically determined high activity of the TNF-α, IL23/IL17, and NFkB pathways increase risk of AS.
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