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Terry Wilkins  - - - 
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Bernd Nowack

170 shared publications

Empa; Swiss Federal Laboratories for Materials Science and Technology; St. Gallen Switzerland

Iseult Lynch

123 shared publications

School of Geography, Earth and Environmental Sciences

Victor Puntes

92 shared publications

Institut Català de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, 08193, Bellaterra, Barcelona, Spain

Vicki Stone

90 shared publications

Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh, Scotland, UK

Teresa Fernandes

86 shared publications

School of Life Sciences, Heriot-Watt University, Edinburgh, UK

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Article 0 Reads 1 Citation Characterization of Nanoparticle Batch-To-Batch Variability Sonja Mülhopt, Silvia Diabaté, Marco Dilger, Christel Adelhe... Published: 08 May 2018
Nanomaterials, doi: 10.3390/nano8050311
DOI See at publisher website ABS Show/hide abstract
A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified polystyrene NMs, which are frequently employed as positive controls for nanotoxicity studies. For 46 different batches of the selected NMs, all physicochemical descriptors as prioritized by the OECD have been fully characterized. The study represents the most complete assessment of NMs batch-to-batch variability performed to date and provides numerous important insights into the potential sources of variability of NMs and how these might be reduced.
Conference 7 Reads 0 Citations SUN: Paving Sustainable Nanoinnovation Antonio Marcomini, Danail Hristozov, Keld Alstrup Jensen, Vi... Published: 31 October 2014
The 4th World Sustainability Forum, doi: 10.3390/wsf-4-d003
DOI See at publisher website
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