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Roberto Greco  - - - 
Top co-authors See all
Pellegrino Musto

385 shared publications

Haematology and Stem Cell Transplantation Unit, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture, Italy

Evert Slob

291 shared publications

Delft University of Technology

Luigi Zeni

276 shared publications

Department of Engineering, University of Campania Luigi Vanvitelli, 81031 Aversa, Italy

M. Bakker

228 shared publications

Faculty of Civil Engineering and Geosciences, TU Delft, Delft, The Netherlands

Michael Lämmerhofer

185 shared publications

Institute of Pharmaceutical Sciences; Pharmaceutical (Bio-)Analysis; University of Tübingen; Tübingen Germany

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Publication Record
Distribution of Articles published per year 
(1997 - 2018)
Total number of journals
published in
 
36
 
Publications See all
Article 0 Reads 0 Citations Antagonism of Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Trigeminal... Chiara DeMartini, Rosaria Greco, Anna Maria Zanaboni, Oscar ... Published: 25 October 2018
International Journal of Molecular Sciences, doi: 10.3390/ijms19113320
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Transient receptor potential ankyrin type-1 (TRPA1) channels are known to actively participate in different pain conditions, including trigeminal neuropathic pain, whose clinical treatment is still unsatisfactory. The aim of this study was to evaluate the involvement of TRPA1 channels by means of the antagonist ADM_12 in trigeminal neuropathic pain, in order to identify possible therapeutic targets. A single treatment of ADM_12 in rats 4 weeks after the chronic constriction injury of the infraorbital nerve (IoN-CCI) significantly reduced the mechanical allodynia induced in the IoN-CCI rats. Additionally, ADM_12 was able to abolish the increased levels of TRPA1, calcitonin gene-related peptide (CGRP), substance P (SP), and cytokines gene expression in trigeminal ganglia, cervical spinal cord, and medulla induced in the IoN-CCI rats. By contrast, no significant differences between groups were seen as regards CGRP and SP protein expression in the pars caudalis of the spinal nucleus of the trigeminal nerve. ADM_12 also reduced TRP vanilloid type-1 (TRPV1) gene expression in the same areas after IoN-CCI. Our findings show the involvement of both TRPA1 and TRPV1 channels in trigeminal neuropathic pain, and in particular, in trigeminal mechanical allodynia. Furthermore, they provide grounds for the use of ADM_12 in the treatment of trigeminal neuropathic pain.
Article 0 Reads 0 Citations Interaction between Perched Epikarst Aquifer and Unsaturated Soil Cover in the Initiation of Shallow Landslides in Pyroc... Roberto Greco, Pasquale Marino, Giovanni Francesco Santonast... Published: 16 July 2018
Water, doi: 10.3390/w10070948
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A physically based mathematical model of the slope of Cervinara (southern Italy), which is characterized by a shallow pyroclastic soil cover laying upon a limestone fractured bedrock, has been developed. Previous and current ongoing monitoring suggested that leakage through the soil–bedrock interface occurred, with leaking water temporarily stored in a perched aquifer located in the upper part of the fractured limestone (epikarst). This aquifer supplied several springs, and recharge to the deeper groundwater circulation occurred. Hence, in the proposed model, the unsaturated water flow taking place within the soil cover is coupled with the saturated water flow in the perched aquifer. The application of the model to the simulation of the slope hydrologic behavior over a period of 11 years, between 2006–2017, provides realistic results in terms of soil storage, epikarst storage, spring discharge, and groundwater recharge. The different response times of soil and epikarst aquifer to precipitation input allow distinguishing the hydrological predisposing causes of potential landsliding (i.e., a few months of persistent rainfall that is capable of filling the epikarst aquifer) from the triggers, which are represented by single intense rainfall events. The application of the model offers a key of interpretation of the hydrological processes leading to the landslide that occurred on 16 December 1999.
Article 0 Reads 0 Citations Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression ... Rosaria Greco, Chiara DeMartini, Anna Maria Zanaboni, Cristi... Published: 13 July 2018
The Journal of Headache and Pain, doi: 10.1186/s10194-018-0879-6
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Calcitonin gene related peptide (CGRP) is a key neuropeptide involved in the activation of the trigeminovascular system and it is likely related to migraine chronification. Here, we investigated the role of CGRP in an animal model that mimics the chronic migraine condition via repeated and intermittent nitroglycerin (NTG) administration. We also evaluated the modulatory effect of topiramate on this experimental paradigm. Male Sprague-Dawley rats were injected with NTG (5 mg/kg, i.p.) or vehicle, every 2 days over a 9-day period (5 total injections). A group of animals was injected with topiramate (30 mg/kg, i.p.) or saline every day for 9 days. Twenty-four hours after the last administration of NTG or vehicle, animals underwent tail flick test and orofacial Von Frey test. Rats were subsequently sacrificed to evaluate c-Fos and CGRP gene expression in medulla-pons region, cervical spinal cord and trigeminal ganglia. NTG administration induced spinal hyperalgesia and orofacial allodynia, together with a significant increase in the expression of CGRP and c-Fos genes in trigeminal ganglia and central areas. Topiramate treatment prevented NTG-induced changes by reversing NTG-induced hyperalgesia and allodynia, and inhibiting CGRP and c-Fos gene expression in all areas evaluated. These findings point to the role of CGRP in the processes underlying migraine chronification and suggest a possible interaction with gamma-aminobutyrate (GABA) and glutamate transmission to induce/maintain central sensitization and to contribute to the dysregulation of descending pain system involved in chronic migraine.
Article 0 Reads 0 Citations Seismic behavior of a low-rise horizontal cylindrical tank Alessandra Fiore, Carlo Rago, Ivo Vanzi, Rita Greco, Bruno B... Published: 12 May 2018
International Journal of Advanced Structural Engineering, doi: 10.1007/s40091-018-0188-y
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Cylindrical storage tanks are widely used for various types of liquids, including hazardous contents, thus requiring suitable and careful design for seismic actions. The study herein presented deals with the dynamic analysis of a ground-based horizontal cylindrical tank containing butane and with its safety verification. The analyses are based on a detailed finite element (FE) model; a simplified one-degree-of-freedom idealization is also set up and used for verification of the FE results. Particular attention is paid to sloshing and asynchronous seismic input effects. Sloshing effects are investigated according to the current literature state of the art. An efficient methodology based on an “impulsive-convective” decomposition of the container-fluid motion is adopted for the calculation of the seismic force. The effects of asynchronous ground motion are studied by suitable pseudo-static analyses. Comparison between seismic action effects, obtained with and without consideration of sloshing and asynchronous seismic input, shows a rather important influence of these conditions on the final results.
Article 0 Reads 0 Citations Paradigm Shift to Neuroimmunomodulation for Translational Neuroprotection in Stroke Diana Amantea, Rosaria Greco, Giuseppe Micieli, Giacinto Bag... Published: 10 April 2018
doi: 10.3389/fnins.2018.00241
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The treatment of acute ischemic stroke is still an unresolved clinical problem since the only approved therapeutic intervention relies on early blood flow restoration through pharmacological thrombolysis, mechanical thrombus removal, or a combination of both strategies. Due to their numerous complications and to the narrow time-window for the intervention, only a minority of stroke patients can actually benefit from revascularization procedures, highlighting the urgent need of identifying novel strategies to prevent the progression of an irreversible damage in the ischemic penumbra. During the past three decades, the attempts to target the pathways implicated in the ischemic cascade (e.g., excitotoxicity, calcium channels overactivation, reactive oxygen species (ROS) production) have failed in the clinical setting. Based on a better understanding of the pathobiological mechanisms and on a critical reappraisal of most failed trials, numerous findings from animal studies have demonstrated that targeting the immune system may represent a promising approach to achieve neuroprotection in stroke. In particular, given the dualistic role of distinct components of both the innate and adaptive arms of the immune system, a strategic intervention should be aimed at establishing the right equilibrium between inflammatory and reparative mechanisms, taking into consideration their spatio-temporal recruitment after the ischemic insult. Thus, the application of immunomodulatory drugs and their ability to ameliorate outcomes deserve validation in patients with acute ischemic stroke.
Article 0 Reads 0 Citations Endocannabinoid System and Migraine Pain: An Update Rosaria Greco, Chiara DeMartini, Anna M. Zanaboni, Daniele P... Published: 19 March 2018
Frontiers in Molecular Neuroscience, doi: 10.3389/fnins.2018.00172
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The trigeminovascular system (TS) activation and the vasoactive release from trigeminal endings, in proximity of the meningeal vessels, are considered two of the main effector mechanisms of migraine attacks. Several other structures and mediators are involved, however, both upstream and alongside the TS. Among these, the endocannabinoid system (ES) has recently attracted considerable attention. Experimental and clinical data suggest indeed a link between dysregulation of this signaling complex and migraine headache. Clinical observations, in particular, show that the levels of anandamide (AEA)—one of the two primary endocannabinoid lipids—are reduced in cerebrospinal fluid and plasma of patients with chronic migraine (CM), and that this reduction is associated with pain facilitation in the spinal cord. AEA is produced on demand during inflammatory conditions and exerts most of its effects by acting on cannabinoid (CB) receptors. AEA is rapidly degraded by fatty acid amide hydrolase (FAAH) enzyme and its levels can be modulated in the peripheral and central nervous system (CNS) by FAAH inhibitors. Inhibition of AEA degradation via FAAH is a promising therapeutic target for migraine pain, since it is presumably associated to an increased availability of the endocannabinoid, specifically at the site where its formation is stimulated (e.g., trigeminal ganglion and/or meninges), thus prolonging its action.
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